张传茂 - 北京大学 - 生命科学学院

个人简介

教育经历: 1989-1993，博士，北京大学细胞生物学专业 1983-1986，硕士，南京农业大学组织学与胚胎学专业工作经历: 2005 - 至今，特聘教授 2002 - 至今，北京大学生命科学学院教授 1993 - 2002，北京大学生命科学学院副教授 1999 - 2002，CRC Senior Traveling Research Fellow，英国丹迪大学. 1997 - 1999，BBSRC Senior Research Fellow，英国曼彻斯特大学 1995 - 1997，Wellcome Trust Senior Traveling Research Fellow，英国丹迪大学社会服务工作: 国家自然科学基金委第三届和第四届生命科学部专家咨询委员会委员；国家自然科学基金委第十一届和第十二届生命科学部专家评审组成员；国务院学位委员会第六届和第七届学科评议组生物学组成员；中国细胞生物学会资深理事；中国生物物理学会常务理事；中国生物物理学会第十届膜与细胞生物物理专业委员会副理事长；教育部重点实验室主任；荣誉奖励: 《细胞生物学》（第5版, 丁明孝，王喜忠，张传茂，陈建国主编）获首届全国教材建设奖（高等教育类）一等奖, 2021；《分子细胞生物学》（第3版, 陈晔光，张传茂，陈佺主编）获首届全国教材建设奖（高等教育类）二等奖，2021；全国高校自然科学奖一等奖（第一完成人），2020；科技部干细胞专项首席，2017；北京大学拜耳学者奖，2015；全国优秀科技工作者，2014；北京市优秀博士学位论文指导教师奖；2011；全国模范教师，2009；北京市优秀教师，2009；国家自然科学基金委员会“创新研究群体” I期（2005）和II期（2008）学术带头人；国务院政府特殊津贴获得者，2008；北京市级高等教育教学成果奖一等奖(丁明孝,陈建国,张传茂,苏都莫日根) ，2004；《细胞生物学》全国高校精品课(丁明孝,陈建国,张传茂,苏都莫日根等），2003；国家自然科学基金委员会“国家杰出青年科学基金”获得者，2003；《细胞生物学》全国优秀教材奖一等奖(编者之一），2002；中国国家自然科学奖二等奖（翟中和,张传茂,张博等七人），2001；中国高校科学技术奖一等奖（翟中和,张传茂,张博等五人），2000

研究领域

1.干细胞增殖与分化； 2.细胞核结构、动态变化与功能； 3.细胞周期调控机理（包括纺锤体装配和核膜装配机理等）； 4.Ran GTP酶系统的功能调控； 5.肿瘤细胞增殖调控

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Tai L*, Zhu Y*, Ren H*, Huang X, Zhang C*, Sun F*. 8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI. Protein Cell. 2022;10.1007/s13238-021-00895-y. doi:10.1007/s13238-021-00895-y 2. Mengjie Sun, Mingkang Jia, He Ren, Biying Yang, Wangfei Chi, Guangwei Xin, Qing Jiang & Chuanmao Zhang*, NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation, NATURE COMMUNICATIONS, 2021, 12:7157 | https://doi.org/10.1038/s41467-021-27528-6. 3. Tenghan Zhuang*, Boyan Zhang, Yihong Song, Fan Huang, Wangfei Chi, Guangwei Xin, Ziyu Zhang, Steven Y. Cheng, Qing Jiang, and Chuanmao Zhang*, Sufu negatively regulates both initiations of centrosome duplication and DNA replication, PNAS, 2021, Vol. 118 No. 28 e2026421118. 4.Wangfei Chi, Gang Wang, Guangwei Xin, Qing Jiang, Chuanmao Zhang* ,PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations, J Cell Biol, 2021, 220 (1): e202002151. https://doi.org/10.1083/jcb.202002151 5. Qiaoyu Lin, Bin Yu, Xiangyang Wang, Shicong Zhu, Gan Zhao, Mingkang Jia, Fan Huang, Nan Xu, He Ren, Qing Jiang, and Chuanmao Zhang*, K6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells, PNAS, 2020,117(19): 10378-10387. 6. Guangwei Xin, Jingyan Fu, Jia Luo, Zhaoxuan Deng, Qing Jiang, and Chuanmao Zhang*, Aurora B regulates PP1γ–Repo-Man interactions to maintain the chromosome condensation state, J. Biol. Chem., 2020, 295(43) :14780–14788. 7. Boyan Zhang, Tenghan Zhuang, Qiaoyu Lin, Biying Yang, Xiaowei Xu, Guangwei Xin, Shicong Zhu, Gang Wang,Bin Yu, Tingting Zhang, Qing Jiang, and Chuanmao Zhang*, Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation, PNAS, 2019,116(3): 874-879. 8. Tingting Zhang, Guangwei Xin, Mingkang Jia, Tenghan Zhuang, Shicong Zhu, Boyan Zhang, Gang Wang, Qing Jiang and Chuanmao Zhang*，The Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1，Journal of Cell Science, 2019, 132, jcs220384. doi:10.1242/jcs.220384. 9. Jia Luo, Biying Yang, Guangwei Xin, Mengjie Sun, X Boyan Zhang, Xiao Guo, Qing Jiang, and Chuanmao Zhang*, The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules, J. Biol. Chem., 2019, 294(14) 5643–5656. 10 He Ren*, Guangwei Xin*, Mingkang Jia, Shicong Zhu, Qiaoyu Lin, Xiangyang Wang, Qing Jiang, and Chuanmao Zhang*, Postmitotic annulate lamellae assembly contributes to nuclear envelope reconstitution in daughter cells. J. Biol. Chem., 2019, 294(27): 10383–10391. 11. Li Guo, Khamsah Suryati Mohd, He Ren, Guangwei Xin, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of importin-α1 by CDK1–cyclin B1 controls mitotic spindle assembly Journal of Cell Science , 2019, 132, jcs232314. doi:10.1242/jcs.232314. 12. Fu Jingyan*, Zhang Chuanmao*, Super-resolution microscopy: successful applications in centrosome study and beyond. Biophysics Reports ,2019, 5(5-6):235-243. 13. Xiaowei Xu*, Shijiao Huang*, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li , Qing Jiang and Chuanmao Zhang*, DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6, Nature Communication, 2017, | 8:15164 | DOI: 10.1038/ncomms15164 | 14. Huabo Chen*, Xiaowei Xu*, Guopeng Wang*, Boyan Zhang, Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, Hongyin Zhang and Chuanmao Zhang*, CDK4 is degraded by APC/C in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells, Journal of Biological Chemistry, 2017, http://www.jbc.org/cgi/doi/10.1074/jbc.M116.773226 15. Boyan Zhang, Gang Wang, Xiaowei Xu, Sisi Yang, Tenghan Zhuang, Guopeng Wang, He Ren,Steven Y. Cheng, Qing Jiang, and Chuanmao Zhang*,DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. Journal of Biological Chemistry, 2017, 292(4): 1351–1360. 16. Junjun Liu* and Chuanmao Zhang*, The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation, Cell. Mol. Life Sci., 2017, DOI 10.1007/s00018-017-2457-5. 17. Tan Qin, Fangjin Chen, Xiaolong Zhuo, Xiao Guo, Taikangxiang Yun, Ying Liu, Chuanmao Zhang*, and Luhua Lai* Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells. Journal of Medicinal Chemistry, 2016, 59: 7089−7096. 18. Wanqing Du, Qian Peter Su, Yang Chen, Yueyao Zhu, Dong Jiang, Yueguang Rong, Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun*, and Li Yu,* Kinesin 1 Drives Autolysosome Tubulation. Development Cell, 2016, 37( 4):326–336. 19. Xiaowei Xu, Jia Luo, Qing Jiang, and Chuanmao Zhang*, Mitotic Spindle Assembly: The Roles of Microtubule Nucleation and Assembly, 2016, In: eLS. John Wiley & Sons, Ltd:Chichester.DOI: 10.1002/9780470015902.a0022518. 20. Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang, Chuanmao Zhang*, DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. Journal of Cell Science, 2016, 129: 1429-1440 doi:10.1242/jcs.178723. 21. Boyan Zhang, Tingting Zhang, Guopeng Wang, Gang Wang, Wangfei Chi, Qing Jiang, Chuanmao Zhang* , GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis. PLoS Biology, 2015, 13(4): e1002129. doi:10.1371/journal.pbio.1002129. 22. Jingyan Fu,* Minglei Bian,* Guangwei Xin, Zhaoxuan Deng,Jia Luo,Xiao Guo, Hao Chen,Yao Wang, Qing Jiang, and Chuanmao Zhang* , TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. Journal of Cell Biology, 2015, 210 (3): 373–383. 23. Xiaolong Zhuo,* Xiao Guo,* Xiaoyan Zhang, Guihua Jing, Yao Wang, Qiang Chen, Qing Jiang, Junjun Liu,* and Chuanmao Zhang* , Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. Journal of Cell Biology, 2015, 210 (5): 727–735. 24. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou*, Qing Jiang*, and Chuanmao Zhang*, Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B. Journal of Biological Chemistry, 2015, 290(28):17546–17558. 25. Ran Q,* Nan Xu,* Gang Wang, He Ren, Si Li, Jun Lei, Qiaoyu Lin, LihaoWang, Xin Gu, Hongyin Zhang, Qing Jiang,* and Chuanmao Zhang* , The lamin-A/C–LAP2–BAF1 protein complex regulates mitotic spindle assembly and positioning. Journal of Cell Science, 2015, 128: 2830-2841. 26. Wu, Yiran、Zhuo, Xiaolong、Dai, Ziwei、Guo, Xiao、Wang, Yao、Zhang, Chuanmao*、Lai, Luhua*，Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations. Mol Biosyst, 2015, 11(2): 497-505. 27. Zhang, Meiling; Sun, Tao; Jian, Chongshu; Lei, Lei; Han, Peidong; Lv, Quanlong; Yang, Ran; Zhou, Xiaohai; Xu, Jiejia; Hu, Yingchun; Men, Yongfan; Huang, Yanyi; Zhang, Chuanmao; Zhu, Xiaojun; Wang, Xianhua; Cheng, Heping; Xiong, Jing-Wei* , Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. PLos One, 2015, 10(7), p e0132567. 28. Gang Wang, Qing Jiang and Chuanmao Zhang*, The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. Journal of Cell Science, 2014,127:4111-4122. 29. Han, Peidong;Zhou, Xiao-Hai;Chang, Nannan;Xiao, Cheng-Lu;Yan, Shouyu;Ren, He;Yang, Xin-Zhuang;Zhang, Mei-Ling;Wu, Qing;Tang, Boyang;Diao, Ju-Peng;Zhu, Xiaojun;Zhang, Chuanmao;Li, Chuan-Yun;Cheng, Heping;Xiong, Jing-Wei*, Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Research, 2014, 24(9),1091-1107. 30. Zhige Wu, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of Crm1 by CDK1–cyclin-B promotes Ran-dependent mitotic spindle assembly, Journal of Cell Science, 2013, 126 (15)：3417–3428. 31. Gang Wang, Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang and Chuanmao Zhang*, PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry, Journal of Cell Science, 2013, 126 (6)： 1355–1365. 32. Wenxiang Fu, Hao Chen, GangWang, Jia Luo, Zhaoxuan Deng, Guangwei Xin, Nan Xu, Xiao Guo, Jun Lei, Qing Jiang and Chuanmao Zhang*, Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly, Proc. Natl. Acad. Sci. USA (PNAS), 2013, 110 (38) : 15295–15300. 33. Quanlong Lu, Zhigang Lu, Qinying Liu , Li Guo, He Ren, Jingyan Fu, Qing Jiang, Paul R Clarke, Chuanmao Zhang*, Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β. Cell Research, 2012, 22:1562-1575. 34. Yueguang Rong; Yuan Tian; Jianzhong Xi; Chuanmao Zhang; Hanshuo Zhang; Zhen Cao; She Chen; Wanqing Du; Lin Li; Ying Li; Mei Liu; Liang Ma; He Ren; Li Yu*, Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nature Cell Biology, 2012, 14(9):924-934. 35. Shiqi Wang; Weiming Xiao; Chuanmao Zhang; Yan Zhang; Juan Chen; Ming Chen; Quan Chen; Chunsun Jiang; Shouqin Lü; Sicong Shan; Mian Long*, Multi-patterned dynamics of mitochondrial fission and fusion in a living cell. PloS one, 2012, 7(5):e19879. 36. Hao-Di Wu, Ming Xu, Rong-Chang Li, Liang Guo, Ying-Si Lai, Shi-Ming Xu,Su-Fang Li, Quan-Long Lu , Lin-Lin Li, Hai-Bo Zhang, You-Yi Zhang, Chuan-Mao Zhang, and Shi-Qiang Wang*, Ultrastructural remodelling of Ca21 signalling apparatus in failing heart cells. Cardiovascular Research, 2012, 95, 430–438. 37. Wenxiang Fu, Qing Jiang and Chuanmao Zhang*, Novel functions of endocytic player clathrin in mitosis. Cell Research, 2011, 21:1655-1661. 38. Xiu-Hua Xue, Chun-Qing Guo, Fei Du, Quan-Long Lu, Chuanmao Zhang and Hai-Yun Ren*, AtFH8 Is Involved in Root Development under Effect of Low-Dose Latrunculin B in Dividing Cells. Molecular Plant, 2011, 4（2）：264–278.