徐冬一 - 北京大学 - 生命科学学院

个人简介

教育经历: 1999-2005, 理学博士, 生命科学, 北京大学 1995-1999, 理学学士, 生命科学, 北京大学工作经历: 2011 - 至今 , 研究员 , 北京大学，生命科学学院 2005 - 2011 , 博士后 , 美国国立卫生研究院（National Institutes of Health，NIH ）

研究领域

1）DNA修复相关的蛋白相互作用组研究 2）揭示DNA损伤修复途径选择与调控的分子机制 3）新的非同源末端连接DNA修复蛋白的功能研究 4）寻找新的癌症治疗的蛋白靶标

近期论文

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1. Chen J, Lu Z, Gong W, Xiao X, Feng X, Li W, Shan S, Xu D*, Zhou Z*. Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2203782119. 2. Feng S, Ma S, Li K, Gao S, Ning S, Shang J, Guo R, Chen Y, Blumenfeld B, Simon I, Li Q, Guo R, Xu D*. RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity. Nature Communications. 2022;13(1):957 3. Xu X, Xu Y*, Guo R, Xu R, Fu C, Xing M, Sasanuma H, Li Q, Takata M, Takeda S, Guo R* and Xu D*. Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress. Nat Struct Mol Biol 2021 Jun;28(6):487-500. 4. Li W, Bai X, Li J, Zhao Y, Liu J, Zhao H, Liu L, Ding M, Wang Q, Shi F-Y, Hou M, Ji J, Gao G, Guo R, Sun Y, Liu Y*, Xu D*. The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. Nature Cell Biology. 2019; 21 (10): 1273-1285. 5. Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R*, Xu D*. A mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Proc Natl Acad Sci U S A. 2018 115(43): E10079-E10088 6. Gao S, Feng S, Ning S, Liu J, Zhao H, Xu Y, Shang J, Li K, Li Q, Guo R*, Xu D*. An OB-fold complex controls the repair pathways for DNA double-strand breaks. Nature Communications 2018;9(1):3925 7. Xu Y, Ning S, Wei Z, Xu R, Xu X, Xing M, Guo R* and Xu D*. 53BP1 and BRCA1 control pathway choice for stalled replication restart. Elife 2017 Nov 6;6. pii: e30523. Recommended in F1000. 8. Ahmad M, Shen W, Li W, Xue Y, Zou S, Xu D*, Wang W*. Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction. Nucleic Acids Res. 2017 Mar 17;45(5):2704-2713 9. Feng S, Zhao Y, Xu Y, Ning S, Hou W, Hou M, Gao G, Ji J, Guo R*, Xu D*. Ewing Tumor-Associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks. J Biol Chem. 2016 Oct 14;291(42):21956-21962. Selected as “Highlights of 2016” of J Biol Chem. 10. Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D*, Wang W*. RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Nucleic Acids Res. 2016 Jul 27;44(13):6335-49 11. Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D* , Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nature Communications, 2015, 6:6233 12. Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D*, Durocher D.A*, A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice. Mol Cell. , 2013, 49(5):872-83. Highlighted by: Science (2013;339:652), Nat Cell Biol. (2013;15:240) and Mol Cell (2013;49:840)