王忆平 - 北京大学 - 现代农学院

个人简介

北京大学生命科学学院教授教育经历 1984年获得中国科技大学生物系分子生物学专业学士学位；1992年获得爱尔兰国立大学科克学院微生物学系博士学位；

研究领域

大肠杆菌及相关细菌中的基因调控网络、大肠杆菌及相关细菌中的基因调控机理、植物与微生物相互作用的分子生物学及功能基因组学研究、生物修复领域的研究

近期论文

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1. Xiang, N., Guo, C., Liu, J., Xu, H., Dixon, R.,* Yang, J.,* and Wang, Y.P.* (2020) Using synthetic biology to overcome barriers to stable expression of nitrogenase in eukaryotic organelles. Proc Natl Acad Sci USA. 117 (28): 16537-16545. doi:10.1073/pnas.2002307117 2..Jiang, F., Li, N., Wang, X., Cheng, J., Huang, Y., Yang, Y., Yang, J., Cai, B., Wang, Y.P., Jin, Q., and Gao, N. (2019) Cryo-EM structure and assembly of an extracellular contractile injection system. Cell 177, 1–14. doi: 10.1016/j.cell.2019.02.020. 3. Yang, J., Xie, X., Xiang, N., Dixon, R.,* and Wang, Y.P.* (2018) A polyprotein strategy for stoichiometric assembly of nitrogen fixation components for synthetic biology. Proc Natl Acad Sci U S A. 201804992; DOI: 10.1073/pnas.1804992115 [Highlighted by Stefan Burén, Gema Ló pez-Torrejón, and Luis M. Rubio (2018) Extreme bioengineering tomeet the nitrogen challenge Proc Natl Acad Sci U S A. doi/10.1073/pnas.1812247115] 4. Zhu, M., Dai, X., Guo, W., Ge, Z., Yang, M., Wang, H., and Wang, Y.P.* (2017) Manipulating bacterial cell cycle and cell size by titrating the expression of ribonucleotide reductase. mBio 8: e01741-17.. 5. Yang, J., Xie, X. Yang, M. Dixon, R.* and Wang, Y.P.* (2017) Modular electron transport chains from eukaryotic organelles function to support nitrogenase activity. Proc Natl Acad Sci U S A. 114: 3009-3011. doi:10.1073/pnas.1620058114 [Highlighted by Vicente, E.J. and Dean, D.R. Keeping the nitrogen-fixation dream alive. Proc Natl Acad Sci U S A. 2017, 114 (12): 3009-3011, doi:10.1073/pnas.1701560114. And by Good A. (2018) Toward nitrogen-fixing plants. Science 359 (6378): 869-870, DOI: 10.1126/science.aas8737]. It has been compiled by the Royal Society of Biology (UK) as one of The Big Biology Breakthroughs of 2017. https://www.rsb.org.uk/about-us/mysociety/158-biologist/features/1881-big-biology-breakthroughs-2017 6. Dai, X., Zhu, M., Warren, M., Balakrishnan, R., Patsalo, V., Okano, H., Williamson, J.R., Fredrick, K., Wang, Y.P.* Hwa, T.* Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nature Microbiology 2016, 2:16231. doi: 10.1038/nmicrobiol.2016.231 7. Zhu, M., Dai, X.,* and Wang, Y.P.* Real time determination of bacterial in vivo ribosome translation elongation speed based on LacZ complementation system. Nucleic Acids Res. 2016, 44 (20): e155. doi: 10.1093/nar/gkw698. 8. Tian, Z.X*., Yi, X.X., Cho, A., O`Gara, F., and Wang, Y.P.* CpxR activates MexAB-OprM efflux pump expression and enhances antibiotic resistance in both laboratory and clinical nalB-type isolates of Pseudomonas aeruginosa. PLOS Pathogens 2016, 12(10):e1005932. doi: 10.1371/journal.ppat.1005932. 9. Wang, J., Yan, D., Dixon, R.*, and Wang, Y.P.* Deciphering the principles of bacterial nitrogen dietary preferences: a strategy for nutrient containment. mBio 2016, 7(4):e00792-16. doi:10.1128/mBio.00792-16. 10. Yang, Y., Darbari, V.C, Zhang, N., Lu, D., Glyde, R., Wang, Y.P., Winkelman, J., Gourse, R.L., Murakami, K.S., Buck, M., Zhang, X.*, Structures of the RNA polymerase-σ54 reveal new and conserved regulatory strategies. Science, 2015, 349: 882-885 doi: 10.1126/science.aab1478