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个人简介

教育经历: 1996-1999,博士,东北师范大学生命科学学院 1993-1996,硕士,东北师范大学生命科学学院 1985-1989,学士,东北林业大学生命科学学院 工作经历: 2001 - 至今,北京大学生命科学学院讲师,副教授,教授 2006 - 2007,Visiting Scholar, DKFZ, 德国国家癌症中心 2002 - 2005,Postdoctoral fellow, University of Wisconsin at Madison,美国威斯康星大学麦迪逊分校生物化学系 1999 - 2001,博士后,北京大学生命科学学院细胞生物学专业   荣誉奖励: 北京大学东宝奖教金 , 2015 北大第五届青年教师教学基本功演示竞赛三等奖 , 2009 教育部自然科学奖二等奖, 2007 学术任职: 科技部国家重点研发计划项目首席科学家 北京大学伦理委员会委员 中国老年医学学会基础与转化医学分会委员 中国生物物理学会衰老分会理事 中国生理学会衰老与健康专业委员会委员

研究领域

1.研究衰老过程中表观遗传编程性变化的作用机制,利用合成生物学鉴别个体衰老的关键信号通路; 2.筛选干预细胞和个体衰老的化学小分子;利用表观遗传遗传编辑转换衰老细胞的命运抉择。 3 研究衰老相关的神经退行性病变的发病机制和表观遗传的调控作用。 3.解析癌化中的表观遗传组、空间转录组以及三维基因组的变化规律和潜在机制

近期论文

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Zhou JT†, Zhang C†, Wei R†, Han M, Wang S, Yang K, Zhang L, Chen W, Wen MZ, Li C, Tao W* and Yuan YJ*. (2021). Exogenous artificial DNA forms chromatin structure with active transcription in yeast.Sci China Life Sci, 2022,65: 851–860 Xiaoke Huang†,Xuebin Zhang†,Le Zong,Qianqian Gao,Chao Zhang,Ran Wei,Yiting Guan,Li Huang,Lijun Zhang, Guoliang Lyv* and Wei Tao*.Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3. Journal of Biological Chemistry, 2021,297(4) 101195 Bo He†, Chao Zhang†, Xiaoxue Zhang†, Yu Fan†, Hu Zeng, Jun`e Liu, Haowei Meng, Dongsheng Bai, Jinying Peng, Qian Zhang*, and Wei Tao* and Chengqi Yi*.Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nature Communications,2021, 12: 0-4249 Chao Zhang†,Xuebin Zhang†,Li Huang,Yiting Guan,Xiaoke Huang,XiaoLi Tian,Lijun Zhang and Wei Tao*. ATF3 drives senescence by reconstructing accessible chromatin profiles. Aging Cell, 2021, 20(3): e13315 Yiting Guan†, Chao Zhang†, Guoliang Lyu, Xiaoke Huang, Xuebin Zhang, Tenghan Zhuang, Lumeng Jia, Lijun Zhang, Chen Zhang*, Cheng Li* and Wei Tao*. Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts. Nucleic Acids Research, 2020, 48:10909–10923 Chao Zhang†, Zihan Xu†, shangda Yang†, Guohua Sun, Lumeng Jia, Lumeng Jia, Zhaofeng Zheng, Quan Gu, Wei Tao*, Hui Cheng*, Cheng Li* and Tao Cheng*. Chromatin architecture landscape in hematopoietic stem and progenitor cell populations. Cell Reports, 2020, 32:108206 Guoliang Lyu#, Yuting Guan# , Chao Zahng, Le Zong, Sun Lei, Xiaoke Huang. Li Huang, Lijun Zhang,Xiaoli Tian,Zhongjun Zhou and Wei Tao*.TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. Nature Communications, 2018,Jul 2;9(1):2560 Meng Chen#, Guoliang Lyu#, Miao Han#, Hongbo Nie#, Ting Shen, Wei Chen, Yichi Niu, Yifan Song, Xueping Li, Huan Li, Xinyu Chen, Ziyue Wang, Zheng Xia, Wei Li, Xiao-Li Tian, Chen Ding, Jun Gu, Yufang Zheng, Xinhua Liu, Jinfeng Hu, Gang Wei*, Wei Tao*, Ting Ni.* 3′ UTR lengthening as a novel mechanism in regulating cellular senescence. Genome Research, 2018, 28: 285-294 Guoliang Lyu, Chao Zhang, Te Ling, Rui Liu, Le Zong, Yiting Guan, Xiaoke Huang, Lei Sun, Lijun Zhang, Cheng Li*, Yu Nie* and Wei Tao*. Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease. BMC Genomics, 2018 19:428 Kai Liu, Lianggong Ding, Yuhong Li, Hui Yang, Chunyue Zhao, Ye Lei , Shuting Han, Wei Tao, Dengshun Miao, Hermann Steller, Michael Welsh* and Lei Liu*.Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. PNAS. 2014,111:13960-65 Min Luo#, Te Ling#, WenbingXie#, He Sun, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Yun Zhao, Tao Ye, Jun Gu, Wei Tao*, Zhigang Lu*, Ingrid Grummt*. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells, 2013, 31:1278-86 Guoliang Lyu, Le Zong, Chao Zhang, Xiaoke Huang, Wenbing Xie, Junnan Fang, Yiting Guan, Lijun Zhang, Ting Ni#, Jun Gu#, Wei Tao# . Metastasis-related methyltransferase Merm1 represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation. Journal of Molecular Cell Biology, 2019, 11(1), 78–90 Ling T, Xie W, Luo M, Shen M, Zhu Q, Zong L, Zhou T, Gu J, Lu Z, Zhang F, Tao W* , CHD4 maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5 , Biochem Biophys Res Commun, 2013, 19:101-107 Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg HG, Grummt I*, Tao W* , The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions, PNAS, 2012, 109:8161-8166 Guanghliang LV, Tan Tan, Zong L, Yuting Guan, Lei Sun, Liang QJ* and Tao W*, Changes in the position and volume of inctive X Chromosomes during G0/G1 trnasition, Chromosome Research, 2018, 26:179-189

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