柴真 - 北京大学 - 生命科学学院

个人简介

教育经历: 1993 - 1997 , 理学博士 , 神经化学和神经毒理学 , 瑞典斯德哥尔摩大学 (Stockholm University, Sweden) 1979 - 1983 , 理学学士 , 生理学 , 北京大学工作经历: 2007 - 至今 , 教授 , 北京大学生命科学学院 1997 - 2007 , 副教授 , 北京大学生命科学学院 1988 - 1993 , 讲师 , 北京大学生命科学学院荣誉奖励: 北京市教育教学成果一等奖 , 2008 国家级教学成果一等奖 , 2005 北京市教育教学成果一等奖 , 2004

研究领域

缺血性脑卒中是危害人类生命健康的重大疾病。在全脑缺血或局部缺血的核心区，胞外谷氨酸浓度可达到100-300mM。谷氨酸的积累造成谷氨酸受体的过度激活，胞内钙离子超载，并引发神经元的凋亡及坏死。本实验室的兴趣在于利用电生理学和激光共聚焦成像技术、结合分子生物学等实验方法，研究脑缺血损伤过程中神经元钙稳态的调控机制、神经元与胶质细胞相互作用机制。另一方面，因冬眠动物达乌尔黄鼠具有耐受低温和低氧环境的特性，以及近期我们证实黄鼠能够一定程度抵抗心脏停跳导致的脑缺血损伤，本实验室希望从神经元及胶质细胞入手深入研究其缺血耐受的神经机制。

近期论文

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1.Zhao YZ, Wei J, Song KX, Zhou C*, Chai Z*. Glutamate-aspartate transporter 1 attenuates oxygen-glucose deprivation-induced injury by promoting glutamate metabolism in primary cortical neurons. Journal of cellular physiology, 2022. 2.Ma YT, Xie HD, Du XM, Wang LP, Jin XQ, Zhang QQ, Han YW, Sun SC, Wang LT, Li X, et al. In vivo chemical reprogramming of astrocytes into neurons. Cell discovery, 2021, 7(1). 3.Su ZJ, Wang XY, Zhou C*, Chai Z*. Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity. Journal of neurochemistry, 2020, 153(5): 617-630. 4.Zhu MY, Zhang DL, Zhou C*, Chai Z*. Mild acidosis protects neurons during oxygen-glucose deprivation by reducing loss of mitochondrial respiration[J]. ACS chemical neuroscience, 2019. 5.Li X, Liu D, Ma Y, et al. Direct reprogramming of fibroblasts via a chemically induced XEN-like state[J]. Cell stem cell, 2017, 21(2): 264-273. e7. 6.Guo Y., Su, ZJ., Chen, YK, & Chai Z*. Brain‐derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons[J]. Journal of neurochemistry, 2017, 142(2): 260-271. 7.Li X, Zuo X, Jing J, et al. Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons[J]. Cell stem cell, 2015, 17(2): 195-203. 8.Zhao JJ, Gao S, Jing JZ, Zhu MY, Zhou C, Chai Z* , Increased Na+/Ca2+ exchanger activity promotes resistance to excitotoxicity in cortical neurons of the ground squirrel (a Hibernator) , PLoS One , 2014 , 9(11): e113594 9.He JQ, Shi WK, Guo Y, Chai Z* , ERp57 modulates mitochondrial calcium uptake through the MCU , FEBS Lett , 2014 , 588: 2087-2094 10.Dong QP, He JQ, Chai Z* , Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia , Neurobiol Dis , 2013 , 58: 68-75 11.Cui J, Wang YF, Dong QP, Wu SM, Xiao XZ, Hu JY, Chai Z*, Zhang Y* , Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70 , J Neurosci , 2011 , 31: 16227-16240 12.Li XC, Wei L, Zhang GQ, Bai ZL, Hu YY, Zhou Z, Bai S, Chai Z, Lakatta EG, Hao XM, Wang SQ* , Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis , PLoS One , 2011 , 6: e24787 (1-9) 13.Zhou C, Qi C, Zhao JJ, Wang F, Zhang WW, Li C, Jing JZ, Kang XJ, Chai Z* , Interleukin-1β inhibits voltage-gated sodium currents in a time- and dose-dependent manner in cortical neurons , Neurochem Res , 2011 , 36: 1116-1123 14.Sun BN, Lv B, Dong QP, Wang SQ, Chai Z* , Watching moving images specifically promotes development of medial area of secondary visual cortex in rat , Dev Neurobiol , 2009 , 69: 558-567 15.Tang AH, Chai Z, Wang SQ* , Dark rearing alters the short-term synaptic plasticity in visual cortex , Neurosci Lett , 2007 , 206: 799-806 16.Zhou C, Ye HH, Wang SQ, Chai Z* , Interleukin-1β regulation of N-type Ca2+ channels in cortical neurons , Neurosci Lett , 2006 , 403: 181-185 17.Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ, Chai Z* , Interleukin-1β downregulates the L-Type Ca2+ channel activity by depressing the expression of channel protein in cortical neurons , J Cell Physiol , 2006 , 206: 799-806. 18.Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ* , Temperature dependence and thermodynamic properties of Ca sparks in rat cardiomyocytes. , Biophys J , 2005 , 89: 2533-2541 19.Alheim K, Chai Z, Fantuzzi G, Hasanvan H, Di Santo E, Ghezzi P, Dinarello CA, Bartfai T* , Hyperresponsive febrile reactions to IL-1β in IL-1β deficient mice; comparison with cytokine mRNA and protein levels. , Proc Natl Acad Sci USA , 1997 , 94: 2681-2686 20.Loudkvist J, Chai Z, Teheranian R, Hasanvan H, Bartfai T, Jenck F, Widmer U, Moreau JL , A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity , Eur. J. Pharmacol. , 1996 , 309: 195-200 21.Chai Z, Alheim K, Lundkvist J, Gatti S, Bartfai T* , Subchromic glucocorticoid pretreatment reversibly attenuates IL-1β induced fever in rats; IL-6 mRNA is elevated while IL-1α and IL-1β mRNAs are suppressed, in the CNS , Cytokine , 1996 , 8: 227-237 22.Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T* , Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: a study on IL-6-deficient mice. , J Exp Med , 1996 , 183: 311-316