白凡 - 北京大学 - 生命科学学院

个人简介

教育经历: 2010.04-2010.05　　Visiting Scholar, Virginia Polytechnic Institute and State University 2004.09-2004.12　　Visiting Scholar, The University of California at Berkeley 2003.09-2008.09　　Doctor of Philosophy major in Biological Physics, University of Oxford 1999.09-2003.06　　Bachelor of Science, Peking University, Department of Physics 工作经历: 2014.09-present　　Assistant Professor, PI 2011.08-2014.08　　Assistant Professor, Co-PI with Professor Sunney Xiaoliang Xie. 2009.09-2011.08　　JSPS Postdoctoral research fellow, Osaka University 2008.09-2009.09　　IRC and EPSRC Postdoctoral research fellow, University of Oxford 荣誉奖励: 国家科技进步奖二等奖（第7完成人），2019 教育部科学技术进步奖一等奖（第5完成人），2019 自然科学基金委优秀青年基金，2017 Bayer-PKU Young Investigator，2017 学术任职: 2017-2020，中国医疗保健国际交流促进会临床微生物与感染分会委员。 2018-2022，中国医药生物技术协会基因检测技术分会委员会常委，副秘书长。 2018-2023，北京亚太肝病诊疗技术联盟肝胆肿瘤专业委员会副主任委员。

研究领域

研究方向一：单细胞基因测序技术应用于癌症病人外周血循环肿瘤细胞研究，深入探索癌症转移的分子生物学机制及通过循环肿瘤细胞测序进行无创癌症诊断、预后判断、疗效评价的临床方法。研究方向二：大样本基因测序研究癌症发生、转移机制。针对明确的临床问题，采用基因测序手段研究中国人群高发癌症的基因突变特征，发掘引起癌症表型转化、转移的关键驱动事件。研究方向三：综合使用基因测序、荧光成像手段研究细菌行为、致病性，抗生素杀菌原理和细菌抗药、耐药的分子机制。

近期论文

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1. Wang J#, Xu Y#, Chen Z#, Liang J#, Lin Z#, Liang H#, ……, Bai F*, Xia H*, Wen Z*, Zhang Y*, Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia, Cell 183 (2020), pp. 1867-1883 2. Li R#, Du Y#, Chen Z#, Xu D#, Lin T#, Jin S, Wang G, Liu Z, Lu M, Chen X, Xu T*, Bai F*, Macroscopic somatic clonal expansion in morphologically normal human urothelium, Science 370 (2020), pp. 82-89 3. Jin S#, Li R#, Chen M#, Yu C#, Tang L#, …….., Mai H, Gewurz B, Zhao B, Young L, Zhong Q*, Bai F*, Zeng M*, Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma, Cell Research 30 (2020), pp. 950-965 4. Zhang J#, Wang X#, Xing X#, Xu Z#, ……., Zhang Y, Zumla A, Maeurer M, Bai F*, Wang F*, Single-cell landscape of immunological responses in patients with COVID-19, Nature Immunology 21 (2020), pp. 1107-1118 5. Zhang C#, Zhang L#, Xu T#, Xue R#, Yu L#, Zhu Y, Wu Y, Zhang Q, Li D, Shen S, Tan D, Bai F*, Zhang H*, Mapping the spreading routes of lymphatic metastases in human colorectal cancer, Nature Communications 11 (2020), 1993 6. Wang X#, Lu Y#, Song Y#, Dong J#, Li R, Wang G, Wang X, Zhang S, Dong Z, Lu M, Wang S, Ge L, Luo G, Ma R, Rozen S, Bai F*, Wu D*, Ma L*, Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus, Nature Communications 11 (2020), 739 7. Huang B#, Chen Z#, Geng L#, Wang J#, Liang H#, ......, Gong S*, Bai F*, Yang M*, Zhang Y*, Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways, Cell 179 (2019), pp. 1160-1176 8. Fujimaki K#, Li R#, Chen H, Della Croce K, Zhang H, Xing J, Bai F*, Yao G*, Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch, Proceedings of the National Academy of Sciences USA 116 (2019), pp. 22624-22634 9. Su Z#, Wang Z#, Ni X#, Duan J#, Gao Y#, Zhuo M, Li R, Zhao J, Ma Q, Bai H, Chen H, Wang S, Chen X, An T, Wang Y, Tian Y, Yu J, Wang D, Xie X*, Bai F*, Wang J*, Inferring evolution and progression of small-cell lung cancer by single-cell sequencing of circulating tumor cells, Clinical Cancer Research 25 (2019), pp. 5049-5060 10. Xue R#, Chen L#, Zhang C#, Fujita M#, ……, Nakagawa H*, Zeng M*, Bai F*, Zhang N*, Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes, Cancer Cell 35 (2019), pp. 932-947 11. Jiang Y#, Ma D#, Suo C#, Shi J#, Xue M#, Liu Y, Xiao Y, Hu X, Yu Y, Zhang J, Li B, Li X, Zheng Y, Ren L, Hou W, Zhao S, Gong Y, Ren Y, Zhang C, Niu Z, Bai F, Yu K, Wang P*, Shi L*, Huang W*, Shao Z*, The genomic and transcriptomic landscape of triple-negative breast cancer suggests subtype-specific treatment strategies in Chinese population, Cancer Cell 35 (2019), pp.428-440.e5 12. Liu M#, Liu Y#, Deng L#, Wang D, He X, Zhou L, Wicha M, Bai F*, Liu S*, Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer, Molecular Cancer 17(2018), pp. 65 13. Chen X#, Yan S#, Liu Y#, Zhong Q#, Chen Z#, Jin S#, Xia T, Li R, Zhou A, Su Z, Huang Y, Huang Q, Huang L, Zhang X, Zhao Y, Yun J, Wu Q, Lin D, Bai F*, Zeng M*, Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole exome sequencing, Nature Communications 8 (2017), pp. 524 14. Gao Y#, Ni X#, Guo H#, Su Z#, Ba Y#, Tong Z, Guo Z, Yao X, Chen X, Yin J, Yan Z, Guo L, Liu Y, Bai F*, Xie S*, Zhang N*, Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells, Genome Research 27 (2017), pp. 1312-1322 15. Du Y#, Li R#, Chen Z#, Wang X, Xu T*, Bai F*, Mutagenic factors and complex clonal relationship of multifocal urothelial cell carcinoma, European Urology 71 (2017), pp. 841–843 16. Xue R#, Li R#, Guo H#, Guo L#, Su Z, Ni X, Qi L, Zhang T, Li Q, Zhang Z, Xie XS, Bai F*, Zhang N*, Variable extent of intra-tumor heterogeneity revealed by genomic sequencing of multiple lesions in patients with hepatocellular carcinoma, Gastroenterology 150 (2016), pp. 998-1008 17. Ni X#, Zhuo M#, Su Z#, Duan J#, Gao Y#, Wang Z#, Zong C#, Bai H, Chapman A, Zhao J, Xu L, An T, Ma Q, Wang Y, Wu M, Sun Y, Wang S, Li Z, Yang X, Yong J, Su X, Lu Y, Bai F*, Xie X*, Wang J*, Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients, Proceedings of the National Academy of Sciences USA 110 (2013), pp. 21083-21088 18. Lu S#, Zong C#, Fan W#, Yang M#, Li J, Chapman A, Zhu P, Hu X, Xu L, Yan L, Bai F, Qiao J, Tang F, Li R*, Xie X*, Probing meiotic recombination and aneuploidy of single sperm cells by whole genome sequencing, Science 338 (2012), pp. 1627-1630