May, Jeremy - University of Houston - Department of Chemistry

个人简介

Ph.D., California Institute of Technology, 2006 B.S., University of Utah (Cum Laude), 2000

研究领域

Synthetic Organic Chemistry and Methods Development The goal of the May group is to make molecules of interest and utility. This goal encompasses the development of powerful synthetic methodologies as well as their application to the synthesis of complex molecules. For example, chemical transformations using transition metal catalysts that stabilize carbene and ylide-like intermediates are sought to form densely functionalized bonds of great utility to the synthetic chemist and to do so with chemo- and stereoselectivity. Furthermore, cascade reactions allow for a variety of bond forming and bond breaking events to occur in one reaction setup, thus providing significant chemical transformation with high efficiency. Target molecules, such as those shown below, are principally complex natural products that exhibit a challenging architecture and intriguing biological properties. Other targets include molecular recognition motifs for directed chemical reactions or molecular biology applications. These compounds have value for therapeutic target identification, pharmaceutical development, protein sequencing, and chemical biology. Training in the lab includes education in the fields of organometallics, organic synthesis, reaction development, mechanism elucidation, natural product chemistry, structural elucidation, scientific writing, and other skills necessary for the practice of chemistry in an academic or commercial environment.

近期论文

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Jansone-Popova, Santa; Le, Phong Q.; May, Jeremy A. Carbene cascades for the formation of bridged polycyclic rings. Tetrahedron 2014, 70, 4118 - 4127. Jones, Amanda C.; May, Jeremy A.; Sarpong, Richmond; Stoltz, Brian M. From Duets to Quintets to a Symphony of Reactivity. Cascades Involving Catalysis and Sigmatropic Rearrangements. Angew. Chem. Int. Ed. 2014, 53, 2556-2591. Smuts, Jonathan P.; Na, Yun-Cheol; Vallakati, Ravikrishna; May, Jeremy A.; Armstrong, Daniel W. Enantioseparation of Flinderoles and Borreverines by HPLC on Chirobiotic V and V2 Stationary Phases and by CE Using Cyclodextrin Selectors. Anal. Bioanal. Chem. 2013, 405, 9169–9177. Vallakati, Ravikrishna; Smuts, Jonathan P.; Armstrong, Daniel W.; May, Jeremy A. On the Biosynthesis and Optical Activity of the Flinderoles. Tetrahedron Lett. 2013, 54, 5892–5894. Besandre, Ron; Jaimes, Miguel; May, Jeremy A. Indoles Synthesized from Amines via Copper Catalysis. Org. Lett. 2013, 15, 1666-1669. Vallakati, Ravikrishna; May, Jeremy A. Biomimetic Syntheses and Studies Toward Enantioselective Synthesis of Flindersial Alkaloids. Chirality 2013, DOI: 10.1002/chir.22134 . Le, Phong Q.; Nguyen, Thien S.; May, Jeremy A. A General Method for the Enantioselective Synthesis of α-Chiral Heterocycles. Org. Lett. 2012, 14, 6104–6107. Vallakati, Ravikrishna; May, Jeremy A. Biomimetic Syntheses of the Flindersia Alkaloids. Synlett 2012, 23, 2577-2581. (Synpacts article) Jansone-Popova; May, Jeremy A. Synthesis of Bridged Polycyclic Ring Systems via Carbene Cascades Terminating in C-H Bond Insertion. J. Am. Chem. Soc. 2012, 134, 17877–17880. Vallakati, Ravikrishna; May, Jeremy A. Biomimetic Synthesis of the Flindersia Alkaloids. J. Am. Chem. Soc. 2012, 134, 6936–6939. Lundy, Brian J.; Jansone-Popova, Santa; May, Jeremy A. The Enantioselective Conjugate Addition of Alkenylboronic Acids to Indole-Appended Enones. Organic Letters 2011, 13, 4958–4951. May, Jeremy A., and Stoltz, Brian M. The Structural and Synthetic Implications of the Biosynthesis of the Calycanthaceous Alkaloids, the Communesins, and Nomofungin. Tetrahedron, 2006, 62, 5262-5271. Julian, Ryan R.; May, Jeremy A.; Stoltz, Brian M.; and Beauchamp, J. L. Biomimetic Approaches to Gas Phase Peptide Chemistry: Combining Selective Binding Motifs with Reactive Carbene Precursors to Form Molecular Mousetraps. International Journal of Mass Spectrometry, 2003, 228(2-3), 851-64. Julian, Ryan R.; May, Jeremy A.; Stoltz, Brian M.; and Beauchamp, J. L. Gas Phase Synthesis of Charged Copper and Silver Fischer Carbenes from Diazomalonates: Mechanistic and Conformational Considerations in Metal Mediated Wolff Rearrangements. Journal of the American Chemical Society, 2003, 125(15), 4478-4486. May, Jeremy A., Zeidan, Ryan K., and Stoltz, Brian M. Biomimetic Approach to Communesin B (a.k.a. Nomofungin). Tetrahedron Letters, 2003, 44, 1203-1205. Julian, Ryan R.; May, Jeremy A.; Stoltz, Brian M.; and Beauchamp, J. L. Molecular Mousetraps: Gas-Phase Studies of the Covalent Coupling of Noncovalent Complexes Initiated by Reactive Carbenes Formed by Controlled Activation of Diazo Precursors. Angewandte Chemie International Edition, 2003, 42(9), 1012-1015 (cover article)."