个人简介
李书鹏
职务：课题组长、特聘研究员
教育背景及工作经历
2016年9月-至今 特聘研究员 北京大学深圳研究生院化学生物学与生物技术学院
2012年10月-2016年8月 助理教授 加拿大 多伦多大学 精神病学系
2010年1月-2016年8月 研究科学家 (Research Scientist) 加拿大 多伦多大学 成瘾与精神卫生研究中心
2005年3月-2009年12月 博士后 加拿大 多伦多大学 成瘾性与精神卫生研究中心
2001年9月 —2005年2月 博士 神经生物学 自然科学学院 国立庆尚大学 晋州, 660-701, 韩国
1998年9月— 2001年7月 硕士 病理生理学 同济医学院 华中科技大学 武汉, 430030, 中国
1993年9月 — 1998年7月 学士 同济医科大学 武汉, 430030, 中国
奖项及荣誉
1999- 2000 华中科技大学研究生奖学金
2002-2005 Rotary 基金会留学生奖学金
2007-2008 CAMH 博士后研究奖学金
2008-2010 加拿大卫生部-TUSP研究奖学金
2008-2010 加拿大心脏病与中风基金会研究奖学金
2011 美洲华人生物学家协会“刘宗正教授“最佳论文奖
2011 Juliusz, Dorota and Zofia (Zosia) 神经精神药理学纪念奖
参与书籍章节
Shupeng Li, Sheng Chen, Yu Tian Wang and Fang Liu. Disrupting protein complexes using Tat-tagged peptide mimics. Signal Transduction Protocols: Methods in Molecular Biology, 2011, Volume 756, Part 6, 381-393.
近期论文
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1. Iqbal S, Shah FA, Naeem K, Nadeem H, Sarwar S, Ashraf Z, Imran M, Khan T, Anwar T, Li S. Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration. Biomolecules. 2020 Mar 13;10(3). pii: E443. doi: 10.3390/biom10030443.
2. Rahman SU, Hao Q, He K, Li Y, Yang X, Ye T, Ali T, Zhou Q, Li S. Proteomic Study Reveals the Involvement of Energy Metabolism in the Fast Antidepressant Effect of (2R, 6R)-Hydroxy Norketamine. Proteomics Clin Appl. 2020 Feb 21:e1900094. doi: 10.1002/prca.201900094.
3. Imran M, Al Kury LT, Nadeem H, Shah FA, Abbas M, Naz S, Khan AU, Li S.Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration. Biomolecules. 2020 Jan 8;10(1). pii: E108. doi: 10.3390/biom10010108.
4. Shah FA, Li T, Kury LTA, Zeb A, Khatoon S, Liu G, Yang X, Liu F, Yao H, Khan AU, Koh PO, Jiang Y, Li S. Pathological Comparisons of the Hippocampal Changes in the Transient and Permanent Middle Cerebral Artery Occlusion Rat Models. Front Neurol. 2019 Nov 14;10:1178. doi: 10.3389/fneur.2019.01178. eCollection 2019.
5. Luo F, Wu L, Zhang Z, Zhu Z, Liu Z, Guo B, Li N, Ju J, Zhou Q, Li S, Yang X, Mak S, Han Y, Sun Y, Wang Y, Zhang G, Zhang Z. The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models. Br J Pharmacol. 2019 Sep;176(17):3318-3335.| doi: 10.1111/bph.14763. Epub 2019 Jul 31.
6. Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, Khalil AAK, Ahmad S, Faheem M, Khan AU, Shah FA, Li S. Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach. Drug Des Devel Ther. 2019 Aug 2;13:2715-2727. doi: 10.2147/DDDT.S207310.
7. Shah FA, Kury LA, Li T, Zeb A, Koh PO, Liu F, Zhou Q, Hussain I, Khan AU, Jiang Y, Li S. Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models. Front Pharmacol. 2019 Jun 26;10:663. doi: 10.3389/fphar.2019.00663. eCollection 2019.
8. He K, Nie L, Zhou Q, Rahman SU, Liu J, Yang X, Li S. Proteomic Profiles of the Early Mitochondrial Changes in APP/PS1 and ApoE4 Transgenic Mice Models of Alzheimer's Disease. J Proteome Res.2019 May 13. DOI: 10.1021/acs.jproteome.9b00136
9. Yu S, Li Y, Chen J, Zhang Y, Tao X, Dai Q, Wang Y, Li S* and Dong M*. TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier Mar. Drugs, 2019 May 12; 17(5), 286;
10. Shah FA, Liu G, Al Kury LT, Zeb A, Abbas M, Li T, Yang X, Liu F, Jiang Y, Li S. Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways. Front Pharmacol. 2019; Mar 29;10:297.
11. Chen C, Jiang X, Li Y, Yu H, Li S, Zhang Z, Xu H, Yang Y, Liu G, Zhu F, Ren X, Zou L, Xu B, Liu J, Spencer PS, Yang X. Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease. Free Radic Biol Med. 2019 May 1;135:144-156.
12. Lipina TV, Beregovoy NA, Tkachenko AA, Petrova ES, Starostina MV, Zhou Q, Li S. Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors. Front Synaptic Neurosci. 2018 Sep 7;10:31.
13. Zhang H, Zhang W, Zhou Y, Jiang Y, Li S. Dual Functional Mesoporous Silicon Nanoparticles Enhance the Radiosensitivity of VPA in Glioblastoma. Transl Oncol. 2017 Apr;10(2):229-240.
14. Zhang H, Li S, Liu P, Lee FH, Wong AH, Liu F. Proteomic analysis of the Cullin4B interactome using proximity-dependent biotinylation in living cells. Proteomics. 2017 Feb 22.
15. Zhang H, Li T, Li S, Liu F. Cross-talk between α7 nAchR and NMDAR revealed by protein profiling. J Proteomics. 2016 Jan 10;131:113-21.
16. Zhang, H.; Jiang, Y.; Zhao, S.-g.; Jiang, L.-q.; Meng, Y.; Liu, P.; Kim, M. O.; Li, S., Selective neuronal targeting, protection and signaling network analysis via dopamine-mediated mesoporous silica nanoparticles. MedChemComm 2015, 6 (6), 1117-1129.
17. Su P*, Li S*, Chen S, Lipina TV, Wang M, Lai TK, Lee FH, Zhang H, Zhai D, Ferguson SS, Nobrega JN, Wong AH, Roder JC, Fletcher PJ, Liu F. A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects. Neuron. 2014. pii: S0896-6273(14)01007-1. (* co-contributor)
18. Li S, Wong AH, Liu F. (2014) Ligand-gated ion channel interacting proteins and their role in neuroprotection. Front Cell Neurosci. 8:125.
19. Li S, Nai Q, Lipina TV, Roder JC, Liu F. (2013) α7nAchR/NMDAR coupling affects NMDAR function and object recognition. Mol Brain. 6(1):58.
20. Zhai D, Li S, Wang M, Chin K, Liu F. (2013) Disruption of the GluR2/GAPDH complex protects against ischemia-induced neuronal damage. Neurobiology of Disease 54:392-403.
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