邹鹏 - 北京大学 - Idg/麦戈文大脑研究所

个人简介

Born and raised in Beijing, Peng Zou was drawn to science as early as in high school. He was a gold medalist in Chinese Chemistry Olympiad and a silver medalist in Chinese Mathematics Olympiad in 2003. Peng attended Peking University from 2003 to 2007 and received his B.S. degree in Chemistry, with a double major in Physics. At PKU, Peng did his undergraduate research in Prof. Bin Xia's group, where he learnt to use nuclear magnetic resonance spectroscopy to solve the three-dimensional structure of proteins. This experience has sparked his interest in applying physical and chemical tools to understand biological functions. After graduation, Peng moved to the U.S. and joined Prof. Alice Ting’s lab at Massachusetts Institute of Technology as a graduate student, where he worked on protein engineering, proteomics, and super-resolution imaging. His thesis led to the development of enzyme-based reporters for mapping proteome and imaging proteins in living cells. Peng obtained his Ph.D. in Biological Chemistry from MIT in 2012. He then worked with Prof. Adam Cohen at Harvard University as a postdoc fellow. His research was focused on developing fluorescent probes for imaging neural activity and applying these tools to study human disease model (e.g. amyotrophic lateral sclerosis) and animal model (e.g. zebrafish brain). These research projects have exposed Peng to a diverse array of disciplines, from protein engineering and cell biology to microscopy and programming. Peng joined Peking University in 2015 as an Assistant Professor in the College of Chemistry and Molecular Engineering. He was also appointed as a Principal Investigator at the PKU-Tsinghua Center for Life Sciences and the PKU-IDG/McGovern Institute for Brain Research. His lab focuses on developing chemistry-enabled tools for mapping neuronal signaling with high spatial and temporal resolutions. Peng was selected as one of C&EN's Talented 12 in 2019, and was appointed as a Young Investigator of Chinese Institute for Brain Research in 2020. He was the recipient of OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface and Bayer Investigtor Award in 2020. In 2021, Peng was promoted to Associate Professor with tenure at Peking University.

研究领域

围绕神经化学生物学开展交叉学科研究，长期致力于发展化学探针技术，解析参与神经活动的生物大分子、生物物理信号及化学信号转导过程。具体研究方向包括：1）发展荧光膜电位探针，实现在高时空分辨下对神经动作电位的可视化观测；2）发展基于酶催化和光催化的生物偶联反应，原位标记和高通量鉴定亚细胞结构中的转录组与蛋白质组； 3）针对上述化学工具发展定向进化技术，实现高效的蛋白质工程改造。这些成果为在高时空分辨下观测神经元活动、解析精细细胞结构提供了新工具。

近期论文

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Enzyme-mediated proximity labeling identifies small RNAs in the endoplasmic reticulum lumen Ren, Z.#, Li, R.#, Zhou, X.#, Chen, Y., Fang, Y. and Zou, P.* (2023) Biochemistry 62, 1844. DOI: 10.1021/acs.biochem.3c00142 Genetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome Zheng, F., Yu, C., Zhou, X. and Zou, P.* (2023) Nat. Commun. 14, 2978. DOI: 10.1038/s41467-023-38565-8 Photocatalytic proximity labeling for profiling the subcellular organization of biomolecules Fang, Y. and Zou, P.* (2023) Chembiochem. 24, e202200745. DOI: 10.1002/cbic.202200745 MERR APEX-seq protocol for profiling subcellular nascent transcriptome in mammalian cells Li, R. and Zou, P.* (2023) STAR Protoc. 4, 102057. DOI: 10.1016/j.xpro.2023.102057 Bioorthogonal chemical ligation creates synthetic antibodies with improved therapeutic potency Wang, R. and Zou, P.* (2023) ACS Cent. Sci. 9, 349-351. DOI: 10.1021/acscentsci.3c00240 Introducing the 2023 Bioconjugate Chemistry Editorial Team Bernardes, G. J. L., Zou, P., Dai, Z., Lavik, E., van Hest, J., Zheng, G., Quinn, N., MacLaughlin, C. M., Reineke, T. M.* (2023) Bioconjugate Chem. 34, 279–282. DOI: 10.1021/acs.bioconjchem.3c00033 A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems Yang, X., Chen, D., Sun, Q., Wang, Y., Xia, Y., Yang, J., Lin, C., Dang, X., Cen, Z., Liang, D., Wei, R., Xu, Z., Xi, G., Xue, G., Ye, C., Wang, L.-P., Zou, P., Wang, S., Rivera-Fuentes, P., Püntener, S., Chen, Z., Liu, Y.*, Zhang, J.* and Zhao, Y.* (2023) Cell Discov. 9, 53. DOI: 10.1038/s41421-023-00543-1 Subcellular interactomes revealed by merging APEX with cross-linking mass spectrometry Sun, M., Yuan, F., Tang, Y., Zou, P.* and Lei, X.* (2022) Anal. Chem. 94, 14878-14888. DOI: 10.1021/acs.analchem.2c02116 Phosphorylation of CENP-R by Aurora B regulates kinetochore-microtubule attachment for accurate chromosome segregation Sedzro, D. M., Yuan, X., Mullen, M., Ejaz, U., Yang, T., Liu, X., Song, X., Tang, Y.-C., Pan, W., Zou, P., Gao, X., Wang, D., Wang, Z., Dou, Z.*, Liu, X.* and Yao, X.* (2022) J. Mol. Cell Biol. 14, mjac051. DOI: 10.1093/jmcb/mjac051 Suborganelle-Specific Protein Complex Analysis Enabled by in Vivo Cross-Linking Coupled with Proximal Labeling An, Y., Zhao, Q.*, Gong, Z., Zhao, L., Li, Y., Liang, Z., Zou, P.*, Zhang, Y. and Zhang, L.* (2022) Anal. Chem. 94, 12051-12059. DOI: 10.1021/acs.analchem.2c01637 Dendritic morphology affects the velocity and amplitude of backpropagating action potentials Tian, W.#, Peng, L.#, Zhao, M.#, Tao, L.*, Zou, P.* and Zhang, Y.* (2022) Neurosci. Bull. in press, DOI: 10.1007/s12264-022-00931-9 DOI: 10.1007/s12264-022-00931-9 Differences in Action Potential Propagation Velocity and Axon Initial Segment Plasticity in Neurons from Sprague Dawley Rats and C57BL/6 Mice Chen, Z., Peng, L., Zhao, M., Tao, L.*, Zou, P.* and Zhang, Y.* (2022) Zool. Res. 43, 615-633. DOI: 10.24272/j.issn.2095-8137.2022.121 Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification Xie, B.#, Pu, Y.#, Yang, F., Chen, W., Yue, W., Ma, J., Zhang, N., Jiang, Y., Wu, J., Lin, Y., Liang, X., Wang, W., Zou, P.* and Li, M.* (2022) Cancer Res. 82, 2576-2592. DOI: 10.1158/0008-5472.CAN-22-0225 Photocatalytic chemical crosslinking for profiling RNA-protein interactions in living cells Luo, H.#, Tang, W.#, Liu, H., Zeng, X., Ngai, W. S. C., Gao, R., Li, H., Li, R., Zheng, H., Guo, J., Qin, F., Wang, G., Li, K., Fan, X.*, Zou, P.* and Chen, P. R.* (2022) Angew. Chem. Int. Ed. Engl. 61, e202202008. DOI: 10.1002/anie.202202008 O-GlcNAcylation modulates liquid-liquid phase separation of SynGAP/PSD-95 Lv, P.#, Du, Y.#, He, C.#, Peng, L., Zhou, X., Wan, Y., Zeng, M., Zhou, W., Zou, P., Li, C., Zhang, M., Dong, S.* and Chen, X.* (2022) Nat. Chem. 14, 831. DOI: 10.1038/s41557-022-00946-9 Metabolic incorporation of electron-rich ribonucleosides enhanced APEX-seq for profiling spatially restricted nascent transcriptome Li, R., Zou, Z., Wang, W. and Zou, P.* (2022) Cell Chem. Biol. 29, 1218. DOI: 10.1016/j.chembiol.2022.02.005 Bringing together the best of chemistry and biology: hybrid indicators for imaging neuronal membrane potential Liu, S.#, Yang, J.# and Zou, P.* (2021) J. Neurosci. Methods 363, 109348. DOI: 10.1016/j.jneumeth.2021.109348 APEX2-based proximity labeling of Atox1 identifies CRIP2 as a nuclear copper-binding protein that regulates autophagy activation Chen, L., Li, N., Zhang, M., Sun, M., Bian, J., Yang, B., Li, Z., Wang, J., Li, F., Shi, X., Wang, Y., Yuan, F., Zou, P., Shan, C. and Wang, J.* (2021) Angew. Chem. Int. Ed. Engl. 60, 25346-25355. DOI: 10.1002/anie.202108961 Targeting cytokinesis bridge proteins to kill high-CIN type tumors Xie, B., Liang, X., Yue, W., Ma, J., Li, X., Zhang, N., Wang, P., Liu, C., Shi, X., Qiao, J., Zou, P. and Li, M.* (2021). Fundamental Research 1, 752-766. DOI: 10.1016/j.fmre.2021.08.015 Spatiotemporally resolved subcellular phosphoproteomics Liu, Y.#, Zeng, R.#, Wang, R., Weng, Y., Wang, R., Zou, P.* and Chen, P. R.* (2021). Proc. Natl. Acad. Sci. U. S. A. 118, e2025299118. DOI: 10.1073/pnas.2025299118 Inhibition of α-synuclein accumulation improves neuronal apoptosis and delayed postoperative cognitive recovery in aged mice Li, Y., Yuan, Y., Li, Y., Han, D., Liu, T., Yang, N., Mi, X., Hong, J., Liu, K., Song, Y., He, J., Zhou, Y., Han, Y., Shi, C., Yu, S., Zou, P., Guo, X.* and Li, Z.* (2021). Oxid. Med. Cell Longev. 2021, 5572899. DOI: 10.1155/2021/5572899 A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons Liu, S.#, Lin, C.#, Xu, Y.#, Luo, H., Peng, L., Zeng, X., Zheng, H., Chen, P. R.* and Zou, P.* (2021). Nat. Chem. 13, 472-479. DOI: 10.1038/s41557-021-00641-1 Spatially resolved cell polarity proteomics of a human epiblast model Wang, S., Lin, C.-W., Carleton, A. E., Cortez, C. L., Johnson, C., Taniguchi, L. E., Sekulovski, N., Townshend, R. F., Basrur, V., Nesvizhskii, A. I., Zou, P., Fu, J.*, Gumucio, D. L.*, Duncan, M. C.* and Taniguchi, K.* (2021). Sci. Adv. 7, eabd8407. DOI: 10.1126/sciadv.abd8407 Spatiotemporal profiling of cytosolic signaling complexes in living cells by selective proximity proteomics Ke, M., Yuan, X., He, A., Yu, P., Chen, W., Shi, Y., Hunter, T., Zou, P. and Tian, R.* (2021). Nat. Commun. 12, 71. DOI: 10.1038/s41467-020-20367-x The evolving capabilities of enzyme-mediated proximity labeling Zhou, Y. and Zou, P.* (2021). Curr. Opin. Chem. Biol. 60, 30-38. DOI: 10.1016/j.cbpa.2020.06.013 COPII mitigates ER stress by promoting formation of ER whorls Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T., Mi, N., Deng, H., Zou, P., Chen, X., Yang, X.* and Yu, L.* (2021). Cell Res. 31, 141-156. DOI: 10.1038/s41422-020-00416-2 Chromophore-assisted proximity labeling of DNA reveals chromosomal organization in living cells Ding, T.#, Zhu, L.#, Fang, Y., Liu, Y., Tang, W. and Zou, P.* (2020). Angew. Chem. Int. Ed. Engl. 59, 22933-22937. DOI: 10.1002/anie.202005486 Protocol for proximity-dependent proteomic profiling in yeast cells by APEX and Alk-Ph probe Li, Y., Liu, K., Zhou, Y., Yang, J.* and Zou, P.* (2020). STAR Protoc. 1, 100137. DOI: 10.1016/j.xpro.2020.100137 A clickable APEX probe for proximity-dependent proteomic profiling in yeast Li, Y., Tian, C., Liu, K., Zhou, Y., Yang, J.* and Zou, P.* (2020). Cell Chem. Biol. 27, 858-865. DOI: 10.1016/j.chembiol.2020.05.006 Exosome alpha-synuclein release in plasma may be associated with postoperative delirium in hip fracture patients Yuan, Y.#, Li, Z.#, Yang, N.#, Han, Y., Ji, X., Han, D., Wang, X., Li, Y., Liu, T., Yuan, F., He, J., Liu, Y., Ni, C., Zou, P., Wang, G.*, Guo, X.* and Zhou, Y.* (2020). Front Aging Neurosci. 12, 67. DOI: 10.3389/fnagi.2020.00067 Genome-wide mapping of oxidative DNA damage via engineering of 8-oxoguanine DNA glycosylase Fang, Y. and Zou, P.* (2020). Biochemistry 59, 85-89. DOI: 10.1021/acs.biochem.9b00782 Imaging neuronal activity with fast and sensitive red-shifted electrochromic FRET indicators Xu, Y.#, Deng, M.#, Zhang, S.#, Yang, J.#, Peng, L., Chu, J.* and Zou, P.* (2019). ACS Chem. Neurosci. 10, 4768-4775. DOI: 10.1021/acschemneuro.9b00501 Dynamic modifications of biomacromolecules: mechanism and chemical interventions Wang, C., Zou, P., Yang, C., Liu, L., Cheng, L., He, X., Zhang, L., Zhang, Y., Jiang, H.* and Chen, P.R.* (2019). Sci. China Life Sci. 62, 1459-1471. DOI: 10.1007/s11427-019-9823-1 Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling Wang, P.#, Tang, W.#, Li, Z.#, Zou, Z., Zhou, Y., Li, R., Xiong, T., Wang, J.* and Zou, P.* (2019). Nat. Chem. Biol. 15, 1110-1119. DOI: 10.1038/s41589-019-0368-5 MRGPRX4 is a bile acid receptor for human cholestatic itch Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., Peng, L., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Zou, P., Lei, X., Luo, W.* and Li, Y.* (2019). Elife 8, e48431. DOI: 10.7554/eLife.48431 Expanding APEX2 substrates for proximity-dependent labeling of nucleic acids and proteins in living cells Zhou, Y.#, Wang, G.#, Wang, P., Li, Z., Yue, T., Wang, J. and Zou, P.* (2019). Angew. Chem. Int. Ed. Engl. 58, 11763-11767. DOI: 10.1002/anie.201905949