个人简介
2012/9-,北京大学化学与分子工程学院化学生物学系,北京大学化学与分子工程学院合成与功能生物分子中心,副研究员
2007/8-2012/9,北京大学化学与分子工程学院北京核磁共振中心,助理研究员(2007-2009),副研究员(2009-2012)
2004/7-2007/7,军事医学科学院生物工程研究所,助理研究员
2004/9-2006/9,中科院微生物所,博士后(导师 高福院士)
1999/9-2004/7,军事医学科学院,遗传学,博士 (导师 黄翠芬院士)
1994/9-1998/7,北京大学,生命科学学院,学士
研究领域
新的疾病(伴随)诊断技术研究及诊断试剂盒研发
建立疾病相关新靶标及候选药物发现的Homics平台
近期论文
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Zhu X, Li R, Xu L, Yin H, Chen L, Yuan Y, Zhong W, Lin J§: A Novel Self-Assembled Mitochondria-Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer. Small 2019, 15(2):e1803428. (IF 13.281 , times cited: 9)
Chen L, Zeng D, Xu N, Li C, Zhang W, Zhu X, Gao Y, Chen PR, Lin J§. Blood-Brain Barrier- and Blood-Brain Tumor Barrier-Penetrating Peptide-Derived Targeted Therapeutics for Glioma and Malignant Tumor Brain Metastases. ACS Appl Mater Interfaces. 2019, 11(45):41889-41897. (IF 9.229, times cited: 11)
Wang X, Liu Y, Fan X, Wang J, Hgai WSC, Zhang H, Li J, Zhang G, Lin J§, Chen PR §. Copper-triggered bioorthogonal cleavage reactions for reversible protein and cell surface modifications. J Am Chem Soc. 2019, 141(43):17133-17141. (IF 15.419, times cited: 18)
Zhong W, Zhu H, Sheng F, Tian Y, Zhou J, Chen Y, Li S§, Lin J§. Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Autophagy 2014, 10(7):1285-1300. (IF 16.016, times cited: 62)
Zhou C, Zhong W, Zhou J, Sheng F, Fang Z, Wei Y, Chen Y, Deng X§, Xia B, Lin J§. Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells. Autophagy 2012, 8(8):1215-1226. (IF 16.016, times cited: 158)