刘志博 - 北京大学 - 化学与分子工程学院

个人简介

2016.07-至今，研究员，北京大学化学与分子工程学院 2016.07-至今，中心研究员，北大-清华生命科学联合中心 2014.09–2016.07，博士后研究员，美国国立卫生研究院 2010.09–2014.09，博士，英属哥伦比亚大学化学系 2011.05–2014.09，跨学科博士培养项目，TRIUMF原子能国家实验室 2012.03–2014.09，跨学科博士培养项目，英属哥伦比亚肿瘤中心 2010.06，理学学士，南京大学化学化工学院化学系

研究领域

以B-F键为基础的18F通用标记法以三氟化硼（-BF3-）与羧酸根（-COO-）的相似性为基础的化学生物学研究以炎症特异性的放射性探针为基础，采用PET影像支持临床中癌症与炎症的鉴别以硼中子捕获治疗（BNCT）为基础的癌症诊疗一体化平台

近期论文

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Yu Liu, Haocheng Tang, Tianchi Song, Mengxin Xu, Junyi Chen, Xi-Yang Cui, Yuxiang Han, Zhu Li, Zhibo Liu*. Organotrifluoroborate Enhances Tumor Targeting of Fibroblast Activation Protein Inhibitors for Targeted Radionuclide Therapy. Euro J Nucl Med Mol Imaging. 2023, https://doi.org/10.1007/s00259-023-06230-3. Yaxin Shi#, Zhibin Guo#, Qiang Fu#, Xinyuan Shen, Zhongming Zhang, Wenjia Sun, Jinqiang Wang, Junliang Sun, Zizhu Zhang, Tong Liu, Zhen Gu*, Zhibo Liu*. Localized Nuclear Reaction Breaks Boron Drug Capsules Loaded with Immune Adjuvants for Cancer Immunotherapy. Nat Commun. 2023, 14: 1884. Dongban Duan#, Yi Han#, Zhiyu Tu#, Haoxuan Guo, Zizhu Zhang, Yaxin Shi, Jiyuan Li, Qi Sun, Junyi Chen, Zhu Li, Tong Liu, Daqing Cui, Zhibo Liu*. Gadolinium Neutron Capture Reaction-Induced Nucleodynamic Therapy Potentiates Antitumor Immunity. CCS Chemistry. 2023, https://doi.org/10.31635/ccschem.023.202202488. Qi Sun#, Jiyuan Li#, Zexuan Ding, Zhibo Liu*. Radiopharmaceuticals heat anti-tumor immunity. Theranostics. 2023, 13(2): 767-786. 李嘉颢, 梁炜秋, 穆博帅, 刘志博*. 二氟甲基自由基反应及其在18F标记中的应用. 高等学校化学学报. 2022, 43(12), 20220652. Qiang Wei, Yuhxuan Lee, Weiqiu Liang, Xiaolei Chen, Bo-Shuai Mu, Xi-Yang Cui, Wangsuo Wu, Shuming Bai, Zhibo Liu*. Photocatalytic Direct Borylation of Carboxylic Acids. Nat Commun. 2022, 13: 7112. Jie Ding, Mengxin Xu, Junyi Chen, Pu Zhang, Li Huo*, Ziren Kong*, Zhibo Liu*. 86Y-Labeled Albumin-Binding Fibroblast Activation Protein Inhibitor for Late-Time-Point Cancer Diagnosis. Mol Pharm. 2022, 19(9): 3429−3438. Zhibin Guo#, Hanyu Hong#, Yuedan Zheng, Ziyang Wang, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors. Angew Chem Int Ed. 2022, 61(34): e202205014. Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu*. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation. ACS Central Science. 2022, 8: 837−844. 陈俊艺, 刘宇, 徐梦欣, 刘志博*. 225Ac-213Bi发生器的制备与使用. 中华核医学与分子影像杂志. 2022, 42(6): 330-334. Xi-Yang Cui, Yu Liu, Changlun Wang, Zihao Wen, Yichen Li, Haocheng Tang, Juan Diwu, Yuchuan Yang, Mengchao Cui, Zhibo Liu*. China's Radiopharmaceuticals on Expressway: 2014-2021. Radiochimica Acta. 2022, https://doi.org/10.1515/ract-2021-1137. Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, and Zhibo Liu*. Radiotherapy reduces N-oxides for prodrug activation in tumors. J Am Chem Soc. 2022, 144(21):9458-9464. Ziren Kong #, Zhu Li #, Junyi Chen #, Wenbin Ma, Yu Wang*, Zhi Yang*, Zhibo Liu*. Larger 18F-fluoroboronotyrosine (FBY) active volume beyond MRI contrast enhancement in diffuse gliomas than in circumscribed brain tumors. EJNMMI Res. 2022, 12(1):22. Jiyuan Li#, Qi Sun#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*. Boron encapsulated in a liposome can be used for combinational neutron capture therapy. Nat Commun. 2022, 13: 2143. Junyi Chen, Jingfeng Wang, MengXin Xu, Xianlu Jia, Guofang Song, Zhibo Liu*. Production of positron-emitting radionuclide yttrium-86 with a computer-aided design target for positron emission tomography. Nucl Med Biol. 2022, 108-109:54-60. Junyi Chen, Mengxin Xu, Yu Liu, Dongban Duan, Yuxiang Han, Zhibo Liu*. Isolation of 212Pb from natural thorium for targeted alpha-therapy. Chin Chem Lett. 2022, 33(7):3474-3477. Ziren Kong#, Zhu Li#, Junyi Chen#, Sirui Liu, Delin Liu, Jiyuan Li, Nan Li, Wenbin Ma, Feng Feng, Yu Wang*, Zhi Yang*, Zhibo Liu*. Metabolic characteristics of [18F] fluoroboronotyrosine (FBY) PET in malignant brain tumors. Nucl Med Biol. 2022, 106-107:80-87. 穆博帅, 徐洋, 刘志博*. 靶向PSMA放射性小分子药物研究进展. 同位素. 2021, 34 (6), 565-580. Pu Zhang#, Mengxin Xu#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*. Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy. Eur J Nucl Med Mol Imaging. 2021, 49, 1985–1996. Huifang He, Jiyuan Li, Ping Jiang, Suqing Tian, Hao Wang, Ruitai Fan, Junqi Liu, Yuyan Yang, Zhibo Liu*. The basis and advances in clinical application of boron neutron capture therapy. Radiat Oncol. 2021, 16(1):216. Mengxin Xu, Pu Zhang, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*. Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J Nucl Med. 2021, doi: 10.2967/jnumed.121.262533. Junyi Chen, Yinlong Lv, Feng Wang, Tianjue Zhang, Zhibo Liu*. Production and isolation of actinium-225 with a 100 MeV proton cyclotron and solid-phase extraction for targeted radiotherapy. Chemistry (HXTB). 2021, 84(11):1211-1219. Chunhong Wang, Hanyu Hong, Mengqi Chen, Zexuan Ding, Yuchen Rui, Zi-Chen Li,Zhibo Liu*. A Cationic Micelle as In Vivo Catalyst for Tumor-Localized Cleavage Chemistry. Angew Chem Int Ed. 2021, 60, 19750-19758 Zhu Li#, Ziren Kong#, Junyi Chen, Jiyuan Li, Nan Li, Zhi Yang*,Yu Wang*, Zhibo Liu*. 18F-Boramino Acid PET/CT in Healthy Volunteers and Glioma Patients. Eur J Nucl Med Mol Imaging. 2021, 48(10):3113-3121. Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*. Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J Am Chem Soc. 2021, 143(5):2250-2255. Jingyun Ren, Mengxin Xu, Junyi Chen, Jie Ding, Peipei Wang, Li Huo*, Fang Li*, Zhibo Liu*. PET Imaging Facilitates Antibody Screening for Synergistic Radioimmunotherapy with A 177Lu-Labeled αPD-L1 Antibody. Theranostics. 2021, 11(1):304-315. Liping Li, Kun Dai, Jiyuan Li, Yaxin Shi, Zizhu Zhang, Tong Liu, Ruiping Zhang*, Zhibo Liu*. A Boron-10 Nitride Nanosheet for Combinational Boron Neutron Capture Therapy and Chemotherapy of Tumor. Biomaterials. 2021, 268:120587. Yaxin Shi, Qiang Fu, Jiyuan Li, Zizhu Zhang, Hui Liu, Tong Liu, Zhibo Liu*. A Covalent Organic Polymer as a Carborane Carrier for Imaging-Facilitated Boron Neutron Capture Therapy. ACS Appl Mater Interfaces. 2020, 12(50): 55564−55573. 徐梦欣, 李一佳, 刘志博*. 细胞标记与体内追踪成像：在动物和人类中应用的最新进展. 中国组织工程研究. 2020, 24(19): 3108-3116. Jiyuan Li, Zhiyu Tu, Zhibo Liu*. 走进曙色的冷门方向：硼携带剂发展历程简述. Scientia Sinica Chimica. 2020, 50: 1296–1319. Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*. External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors. Angew Chem Int Ed. 2020, 59(48): 21546–21552. Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*. A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature. 2020, 579, 421–426. Junyi Chen, Cong Li, Hanyu Hong, Hui Liu, Chunhong Wang, Mengxin Xu, Yuxiang Han, Zhibo Liu*. Side Chain Optimization Remarkably Enhances the In Vivo Stability of 18F-Labeled Glutamine for Tumor Imaging. Mol Pharm. 2019,16, 12, 5035–5041. Qunfeng Fu, Junyi Chen,Zhibo Liu*. Cherenkov Light: A New Light Source for Theranostics With Nano-Drug. J Nucl Radiochem. 2019: 41(2): 201-207. Jiyuan Li, Yaxin Shi, Zizhu Zhang, Hui Liu, Lixin Lang, Tong Liu, Xiaoyuan Chen*, Zhibo Liu*. A Metabolically Stable Boron-Derived Tyrosine Serves as a Theranostic Agent for Positron Emission Tomography Guided Boron Neutron Capture Therapy. Bioconjug Chem. 2019, 30 (11), 2870-2878. Liping Li, Jiyuan Li, Yaxin Shi, Ping Du, Zizhu Zhang, Tong Liu, Ruiping Zhang*, Zhibo Liu*. On-Demand Biodegradable Boron Nitride Nanoparticles for Positron Emission Tomography Guided Boron Neutron Capture Therapy. ACS Nano. 2019, 13 (12), 13843-13852. Hsiou-Ting Kuo, Mathieu Lepage, Kuo-Shyan Lin, Jinhe Pan, Zhengxing Zhang, Zhibo Liu, Alla Pryyma, Chengcheng Zhang, Helen Merkens, Aron Roxin, David Perrin, Francois Benard. One-step 18F-labeling and preclinical evaluation of prostate specific membrane antigen trifluoroborate probes for cancer imaging. J Nucl Med. 2019, 60(8), 1160-1166. Shi, Yaxin; Li, Jiyuan; Zhang, Zizhu; Duan, Dongban; Zhang, Zhengchu; Liu, Hui; Liu, Tong; Liu, Zhibo*. Tracing Boron with Fluorescence and PET Imaging of Boronated Porphyrin Nanocomplex for Imaging Guided Boron Neutron Capture Therapy. ACS Appl Mater Interfaces. 2018, 10, 50, 43387-43395 Dongban Duan, Hui Liu, Mengxin Xu, Mengqi Chen, Yuxiang Han, Yaxin Shi, Zhibo Liu*. Size-Controlled Synthesis of Drug Loaded Zeolitic Imidazolate Framework in Aqueous Solution and Size Impact on Their Cancer Theranostics In Vivo. ACS Appl Mater Interfaces. 2018, 10(49): 42165-42174. Cong Li, Hui Liu, Dongban Duan, Zhenhan Zhou, Zhibo Liu*. Preclinical Study of An 18F-Labeled Glutamine Derivative for Cancer Imaging. Nucl Med Biol. 2018, 64: 34-40. Mengxin Xu, Yuxiang Han, Guizhong Liu, Yang Xu, Dongban Duan, Hui Liu, Felix Du, Peter Luo, Zhibo Liu*. Preclinical Study of A Fully Human Anti-PD-L1 Antibody as A Theranostic Agent for Cancer Immunotherapy. Mol Pharm. 2018, 15(10): 4426-4433. Dongban Duan, Hui Liu, Yang Xu, Yuxiang Han, Mengxin Xu, Zhengchu Zhang, Zhibo Liu*. Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy. ACS Appl Mater Interface. 2018, 10, 5278-5286. Hui Liu, Yuxiang Han, Jiyuan Li, Ming Qin, Qunfeng Fu, Chunhong Wang, and Zhibo Liu*. (18)F-Alanine Derivative Serves as an ASCT2 Marker for Cancer Imaging. Mol Pharm. 2018, 15, 947-954. Cong Li, Hui Liu, Yuxiang Han, Zhibo Liu*. Nuclear Medicine: The Synergy of Radiochemistry and Molecular Medicine. University Chemistry. 2018, 33(3): 1-10. Xiangyu Yang,† Zhibo Liu,† Huimin Zhang, Zhu Li, Jeeva P. Munasinghe, Gang Niu, Gaojun Teng, Xiaoyuan Chen. Preclinical evaluation of an (18)F-trifluoroborate methionine derivative for glioma imaging. Eur J Nucl Med Mol Imaging. 2018, 45, 585-592. Feng Wang, Teli Liu, Liqiang Li, Xiaoyi Guo, Dongban Duan, Zhibo Liu, Hua Zhu, Zhi Yang. Production, quality control of next-generation PET radioisotope iodine-124 and its thyroid imaging. J Radioanal Nucl Chem. 2018, 318, 1999–2006.