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个人简介

教育经历 2008年09月-2013年01月,清华大学,博士 2005年09月-2008年07月,沈阳药科大学,硕士 2001年09月-2005年07月,齐齐哈尔大学,学士 工作经历 2019年08月-至今,清华大学深圳国际研究生院,讲师 2018年03月-2019年08月,清华大学深圳研究生院,讲师 2015年07月-2018年02月,中国科学院大连化学物理研究所与南方科技大学联培,博士后 2013年03月-2015年08月,南方科技大学,Research Fellow(助理研究员) 荣誉奖项 Shenzhen High-level Professional Reserve Talent, Shenzhen, 2020 The winner of SUSTech Presidential Postdoctoral Fellowship (Top 10%), SUSTech, China. 2017

研究领域

主要研究方向:(1) 基于人工智能(AI)技术的多靶点抗肿瘤小分子化合物的设计、合成及其活性研究;(2) 手性药物导向的过渡金属/小分子协同催化的不对称合成。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Jin-Shun Lin #, Tao-Tao Li #, Guan-Yuan Jiao #, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and XinYuan Liu*. “Chiral Br?nsted Acid-Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes. Angew. Chem. Int. Ed.2019, 58, 7092. (#Co-first author) Highlighted in Synfacts2019, 15, 662. Jin-Shun Lin #, Tao-Tao Li #, Ji-Ren Liu #, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong* and Xin-Yuan Liu*.“Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes’’. J. Am. Chem. Soc. 2019, 141, 1074. (#Co-first author) Highlighted in Synfacts2019, 15, 0255. Fu-Li Wang #, Xiao-Yang Dong #, Jin-Shun Lin#,Yang Zeng, Guang-Yuan Jiao, Qiang-Shuai Gu, Xiang-Qi Guo, Can-Liang Ma, Xin-Yuan Liu*.“Catalytic Asymmetric Radical Diamination of Alkenes. Chem 2017. 3, 979. (#Co-first author) Highlighted in Chem2017, 3, 919. Jin-Shun Lin #, Fu-Li Wang #, Xiao-Yang Dong #, Wei-Wei He, Yue Yuan, Su Chen, Xin-Yuan Liu*. “Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines”. Nat. Commun.2017,8, 14841. (#Co-first author). Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu*. “A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes”. J. Am. Chem. Soc. 2016, 138, 9357. Highlighted in Synfacts, 2016, 12, 1020.Highlighted in Chin. J. Org. Chem.2016, 36, 2247. Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu*. “Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter”. Angew. Chem. Int. Ed.2015, 54, 7847. Highlighted in Chin. J. Org. Chem., 2015, 35, 1802. Lijuan Liu#, Zhichao Shi#, Xun Zhang, Feng Zhan, Jin-Shun Lin,* and Yuyang Jiang*. “Synthesis of α-Amino Tertiary Alkylperoxides by Lewis AcidCatalyzed Peroxidation of 1,3,5-Triazines”. Chem Asian J. 2021,16, 3487. (#Co-first author) Zhichao Shi#, Tingting Fan#, Xun Zhang Feng Zhan, Zhe Wang,Lei Zhao, Jin-Shun Lin* and Yuyang Jiang*. “Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity”. Adv. Synth. Catal. 2021,363, 2619. (#Co-first author) Zhe Wang #, Jiang-Tao Cheng #, Zhichao Shi, Na Wang, Feng Zhan, Sheng-Peng Jiang, Jin-Shun Lin,* Yuyang Jiang,* and Xin-Yuan Liu.* “Catalytic Asymmetric Intermolecular RadicalAminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis”.ChemCatChem2021, 13, 185. (#Co-first author). Qinglu Zuo, Zhichao Shi, Feng Zhan, Zhe Wang, Jin-Shun Lin,*Yuyang Jiang,*“TfOH-catalyzed Formal [3+2] Cycloaddition of N-tosylaziridine Dicarboxylates and Nitriles: Synthesis of Tetrafunctionalized 2-Imidazolines”.Tetrahedron Lett.2020, 61, 151576. Yueying Zhang, Dan Gao,* Shangfu Li, Weili Wei, Jinshun Lin and Yuyang Jiang “1,5-Diaminonaphthalene functionalized carbon nanodots as a novel matrix for the analysis of small molecules by matrix-assisted laser desorption/ionization mass spectrometry”.Anal. Methods 2019, 11, 1131. Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles”. Chem. Eur. J.2014, 20, 1332. Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu*. “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles”. J. Org. Chem. 2014, 79, 7084. Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*. “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene”.Angew. Chem. Int. Ed.2014, 53, 11890. Highlighted in Synfacts, 2014, 10, 1281. Zigao Yuan, Shaopeng Chen, Chunmei Gao, Qiuzi Dai, Cunlong Zhang, Qinsheng Sun, Jin-Shun Lin, Chun Guo, Yuzong Chen, Yuyang Jiang.* “Development of a versatile DNMT and HDAC inhibitor C02S modulating multiple cancer hallmarks for breast cancer therapy”. Bioorg Chem.2019, 87, 200.

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