个人简介
教育经历
2000年09月-2005年07月 中国医学科学院&北京协和医学院，药用植物研究所，硕博连读，药理学博士
1993年09月-1997年07月 湖南中医药大学，药学本科，学士
工作经历
2012年12月至今 清华大学深圳研究生院，药理学副教授
2014年12月-2015年12月 美国宾夕法尼亚大学医学院，国家公派访问学者
2013年06月-2013年09月 美国理海大学（Lehigh University）, 短期访问学者
2007年07月-2012年11月 清华大学深圳研究生院，药理学讲师
2005年07月-2007年06月 清华大学深圳研究生院，生物学博士后
1997年09月-2000年07月 益阳医学高等专科学校，药理学助理教师
学术兼职
《Molecules》杂志编委；《Chinese Journal of Integrative medicine》杂志编委
研究领域
分子药理学与创新药物研究。主要运用药理学思维，依托分子与细胞生物学等先进技术平台，发挥整体动物研究特长，实施转化医学策略，从事重大疾病创新药物研究。具体表现为制作和优化糖尿病、高脂血症、肥胖等经典药理动物模型，探讨上述疾病发生、发展与转归的生物学规律，寻找能有效防治该类型疾病的创新药物。
近期论文
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Yangyang Wang#, Yipei Ding#,Pengbo Sun#, Wanqiu Zhang#, Qilei Xin, Ningchao Wang, Yaoyun Niu, Yang Chen, Jingyi Luo, Jinghua Lu, Jin Zhou, Naihan Xu, Yaou Zhang, Weidong Xie*. Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway. Antioxidants 2022, 11(5), 799.
Liao W#, Xu N#, Zhang H, Liao W, Wang Y, Wang S, Zhang S, Jiang Y, Xie W*, Zhang Y*. Persistent high glucose induced EPB41L4A-AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non-histones. Clinical and Translational Medicine. 2022 Feb;12(2): e699.
Yaoyun Niu#, Yuehui Zhang#, Yang Chen, Wanqiu Zhang, Wenhui Hao, Jinghua Lu, Jin Zhou, Lijun Wang, Weidong Xie*. Canagliflozin ameliorates NLRP3 inflammasome-mediated inflammation through inhibiting NF-κB signaling and upregulating Bif-1. Frontiers in Pharmacology. 2022 Mar 28; 13:820541.
Luo J, Sun P, Zhang X, Lin G, Xin Q, Niu Y, Chen Y, Xu N, Zhang Y, Xie W*. Canagliflozin Modulates Hypoxia-Induced Metastasis, Angiogenesis and Glycolysis by Decreasing HIF-1α Protein Synthesis via AKT/mTOR Pathway. International Journal of Molecular Sciences. 2021 Dec 11;22(24):13336.
Luo J, Sun P, Wang Y, Chen Y, Niu Y, Ding Y, Xu N, Zhang Y, Xie W*. Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway. European Journal of Pharmacology. 2021 Jul 3; 907:174304.
Pengbo Sun#, Yangyang Wang#, Yipei Ding, Jingyi Luo, Jin Zhong, Naihan Xu, Yaou Zhang, Weidong Xie*. Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic hearts by inhibiting the mTOR/HIF-1α pathway. iScience. 2021 May 7;24(6):102521.
Yaoyun Niu#, Yang Chen#, Pengbo Sun, Yangyang Wang, Jingyi Luo, Yipei Ding, Weidong Xie*. Intragastric and atomized administration of canagliflozin inhibit inflammatory cytokine storm in lipopolysaccharide-treated sepsis in mice: a potential COVID-19 treatment. International Immunopharmacology. 2021 Jul; 96:107773.
Zhong J#, Sun P#, Xu N, Liao M, Xu C, Ding Y, Cai J, Zhang Y*, Xie W*. Canagliflozin inhibits p-gp function and early autophagy and improves the sensitivity to the antitumor effect of doxorubicin. Biochemical Pharmacology. 2020 May; 175:113856.
Zhao Y#, Wang Z#, Mao Y, Li B, Zhu Y, Zhang S, Wang S, Jiang Y, Xu N, Xie Y, Xie W*, Zhang Y*. NEAT1 regulates microtubule stabilization via FZD3/GSK3β/P-tau pathway in SH-SY5Y cells and APP/PS1 mice. Aging (Albany NY). 2020 Nov 18;12(22):23233-23250.
Lee M, Zhao H, Liu X, Liu D, Chen J, Li Z, Chu S, Kou X, Liao S, Deng Y, Li H*, Xie W*. Protective Effect of Hydroxysafflor Yellow A on Nephropathy by Attenuating Oxidative Stress and Inhibiting Apoptosis in Induced Type 2 Diabetes in Rat. Oxidative Medicine and Cellular Longevity. 2020 Mar 11; 2020:7805393.
Xu C#, Wang W#, Zhong J, Lei F, Xu N, Zhang Y, Xie W*. Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells. Biochemical Pharmacology. 2018 Mar 15; 152:45-59
Liao M, Liu Q, Li B, Liao W, Xie W*, Zhang Y*. A group of long noncoding RNAs identified by data mining can predict the prognosis of lung adenocarcinoma. Cancer Science. 2018 Dec;109(12):4033-4044.
Wan G#, Xie W#, Liu Z, Xu W, Lao Y, Huang N, Cui K, Liao M, He J, Jiang Y, Yang BB, Xu H, Xu N, Zhang Y. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014;10(1):70-9.
Xie Weidong, Zhao Yunan, Du Lijun*. Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia. Journal of Ethnopharmacology 2012;140(2):345-67.
Weidong Xie, Lijun Du*. Diabetes is an inflammatory disease: evidences from traditional Chinese Medicines. Diabetes, Obesity and Metabolism 2011; 13:289-301.
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