Yao, Xudong - University of Connecticut

个人简介

Postdoctoral Associate, University of Maryland, 1999-2002 Ph.D. University of Maryland Baltimore County M.S. Nanjing University, China B.S. Nanjing University, China

研究领域

Proteomic chemistry. Novel and broadly applicable technologies for complex "-ome" analysis, currently focusing on the method and technology development of ultrathroughput mass spectrometry. Mass spectrometry of membrane proteins and proteomes. Systems proteomics of cellular signal transduction.

近期论文

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“A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface.” Hildebrandt E, Ding H, Mulky A, Dai Q, Aleksandrov AA, Bajrami B, Diego PA, Wu X, Ray M, Naren AP, Riordan JR, Yao X, DeLucas LJ, Urbatsch IL, Kappes JC. Mol. Biotechnol. 2015 Jan 11. [Epub ahead of print] “Targeted Proteomic Quantitation of Absolute Expression and Turnover of Cystic Fibrosis Transmembrane Conductance Regulator in Apical Plasma Membrane,” Adam J. McShane; Bekim Bajrami, Alexis Ramos, Pamela Diego-Limpin, Vahid Farrokhi, Bonita Coutermarsh, Bruce Stanton, Timothy Jensen, John R. Riordan, Diana Wetmore, Elizabeth Joseloff, Xudong Yao; Journal of Proteome Research, Special Issue–Proteomics of Human Diseases: Pathogenesis, Diagnosis, Prognosis and Treatment. 2014 Nov 7;13(11):4676-85 “Peptide Dimethylation: Fragmentation Control via Distancing the Dimethylamino Group,” Adam J. McShane, Yuanyuan Shen, Mary Joan Castillo, Xudong Yao; Journal of The American Society for Mass Spectrometry, 2014 Oct;25(10):1694-704. “Quantitative Protein Analysis Using Enzymatic [18O]Water Labeling,” Mary Joan Castillo, Kristy J. Reynolds, Alexander Gomes, Catherine Fenselau, and Xudong Yao, Curr Protoc Protein Sci. 2014 Apr 1;76:23.4.1-9. “An Overview of Quantitative Proteomic Approaches,” Adam J. McShane, Vahid Farrokhi, Reza Nemati, Song Li, Xudong Yao; “Fundamentals of Advanced Omics Technologies: From Genes to Metabolites,” Comprehensive Analytical Chemistry (Volume 63), edited by Carolina Simó, Alejandro Cifuentes, Virginia García-Cañas, 2014, 111-135. “Stable Isotope Dilution Mass Spectrometry for Membrane Transporter Quantitation,” Vahid Farrokhi, Adam J. McShane, Reza Nemati, Xudong Yao; The AAPS Journal, 2013, 15(4), 1222-1231. “Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis,” Vahid Farrokhi, Reza Nemati, Frank C Nichols, Xudong Yao, Emily Anstadt, Mai Fujiwara, James Grady, Daniel Wakefield, Wanda Castro, James Donaldson, Robert B Clark; Clinical & Translational Immunology, 2013, 2, e8; doi:10.1038/cti.2013.11. “Serine Lipids of Porphyromonas gingivalis are Human and Mouse Toll-like Receptor 2 Ligands,” Robert B. Clark, Jorge L. Cervantes, Mark W. Maciejewski, Vahid Farrokhi, Reza Nemati, Xudong Yao, Emily Anstadt, Mai Fujiwara, Kyle T. Wright, Caroline Riddle, Carson J. La Vake, Juan C. Salazar, Sydney Finegold, Frank C. Nichols; Infection and Immunity, 2013, 81(9), 3479-3489. “Quantitative Proteomics in Development of Disease Protein Biomarkers,” Xudong Yao, Adam J. McShane, Mary Joan Castillo; “Proteomic and Metabolomic Approaches to Biomarker Discovery,” edited by Haleem J. Issaq, Timothy D. Veenstra, 2013, 259-278. “Back to Deuterium: Utility of 2H-Labeled Peptides for Targeted Quantitative Proteomics,” Bekim Bajrami, Vahid Farrokhi, Mengtan Zhang, Ardit Shehu, Xudong Yao; International Journal of Mass Spectrometry, 2012, 312, 17-23. “Free lipid A Isolated from Porphyromonas Gingivalis Lipopolysaccharide is Contaminated with Phosphorylated Dihydroceramide Lipids: Recovery in Diseased Dental Samples,” Frank C. Nichols, Bekim Bajrami, Robert B. Clark, William Housley, Xudong Yao; Infection and Immunity, 2012, 80(2), 860-874. “Derivatization or Not: A Choice in Quantitative Proteomics,” Xudong Yao; Analytical Chemistry, 2011, 83(12), 4427-4439. “Phosphorylated Dihydroceramides from Common Human Bacteria are Recovered in Human Tissues,” Nichols FC, Yao X, Bajrami B, Downes J, Finegold SM, Knee E, Gallagher JJ, Housley WJ, Clark RB; PLoS One. 2011, 6(2), e16771. “Ultrathroughput Multiple Reaction Monitoring Mass Spectrometry,” Xudong Yao, Bekim Bajrami, Yu Shi; Analytical Chemistry, 2010, 82, 974-979. “Site-Preferential Dissociation of Peptides with Active Chemical Modification for Improving Fragment Ion Detection,” Pamela A. C. Diego, Bekim Bajrami, Hui Jiang, Yu Shi, Jose Gascon, Xudong Yao; Analytical Chemistry, 2010, 82, 23-27. “Targeted Quantitation of Overexpressed and Endogenous Cystic Fibrosis Transmembrane Conductance Regulator Using Multiple Reaction Monitoring Tandem Mass Spectrometry and Oxygen Stable Isotope Dilution,” Hui Jiang, Alexis A. Ramos, Xudong Yao; Analytical Chemistry, 2010, 82, 336-342. “FerriNaphth: a Fluorescence Chemodosimeter for Redox Active Metal Ion,” Randy K. Jackson, Yu Shi, Xudong Yao, Shawn C. Burdette, Dalton Trans., 2010, 39, 4155-4161. “Analysis of Monomeric and Dimeric Phosphorylated Forms of Protein Kinase R,” Eric Anderson, Christine Quartararo, Raymond S. Brown, Yu Shi, Xudong Yao, James L. Cole, Biochemistry, 2010, 49, 1217-1225. “Design and Synthesis of an Activity-Based Probe Template for Protein Kinase,” Santosh, Keshipeddy, Yu Shi, Xudong Yao, Amy R. Howell; Synlett, 2010, 521-524. “Shifting Unoccupied Spectral Space in Mass Spectrum of Peptide Fragment Ions,” Bekim Bajrami, Yu Shi, Pascal Lapierre, Xudong Yao; Journal of American Society for Mass Spectrometry, 2009, 20, 2124-2134.