吴耀炯 - 清华大学 - 深圳国际研究生院

个人简介

教育经历 1999-2003，多伦多大学，理学博士(实验医学与病理生物学) 1983-1986，兰州大学医学院，硕士(病理学) 1978-1983，青岛医学院，医学学士工作经历 2008-至今，清华大学深圳国际研究生院，教授 2005-2008，加拿大阿尔伯特大学，助理教授 2003-2005，美国哈佛医学院、杜克大学，博士后（干细胞组织再生医学） 1997-1999，加拿大英属哥伦比亚大学博士后荣誉奖项 2021中国生物材料学会科学技术奖一等奖 2019广东省自然科学奖二等奖 2016深圳市自然科学奖二等奖 2012深圳市孔雀人才（B）获加拿大CIHR Fellowship Award 2004 1986-1997，首都医科大学附属医院，历任医师、副主任医师、副教授、学科带头人

研究领域

主要从事干细胞与再生医学研究，尤其是间充质干细胞迁徙机制及皮肤干细胞再生微环境领域。建立了基于3D培养方法的高迁徙间充质干细胞制备技术，解决了间充质干细胞静脉注射后的肺血管阻塞问题，大幅提高了其组织修复效果，技术正与国药集团联合进行干细胞成药转化，并进一步研发针对不同疾病的制剂。在皮肤再生领域，提出并证明了间充质干细胞皮肤修复作用的旁分泌机制，被同行广泛接受；揭示了巨噬细胞因子在毛囊干细胞激活与毛囊再生中的重要作用；初步建立了基于自体皮肤干细的皮肤和毛囊再生方法，目前正研究建立毛囊类器官及其在药物检测和筛选中的应用。

近期论文

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Li Y, Dong Y, Ran Y, Zhang Y, Wu B, Xie J, Cao Y, Mo M, Li S, Deng H, Hao W, Yu S, Wu Y*. Three-dimensional cultured mesenchymal stem cells enhance repair of ischemic stroke through inhibition of microglia. Stem Cell Res Ther. 2021; 12(1):358. Wang J, Wang XX, Xie J, Yao B, Mo M, Ma D, Huang C, Xu RH, Fu X, Tredget EE*, Wu Y*. Engineered skin substitute regenerates the skin with hair follicle formation. Biomedicine 2021; 9(4):400. Chen H, Wang X, Chen Y, Han J, Kong D, Zhu M, Fu X, Wu Y*. Pten loss in Lgr5+ hair follicle stem cells promotes SCC development. Theranostics 2019; 9(26):8321-8331. Mo M, Zhou Y, Li S, Wu Y*. 3D culture reduces cell size by increasing vesicle excretion. Stem Cells 2018; 36(2):286-292. Wang X, Chen H, Tian R et al. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF. Nature Communication. 2017; 27;8:14091 Wang X, Wang X, Cai T et al. De novo hair follicle and sebaceous gland regeneration with cultured stem cells. Stem Cells Translational Medicine. 2016; 5(12):1695-1706. Wang X, Wang J, Guo L et al. Self-assembling peptide hydrogel scaffolds support stem cell-based hair follicle regeneration. Nanomedicine. 2016; 12(7):2115-2125 Wang S, Guo L, Ge J et al. Excess Integrins Cause Lung Entrapment of Mesenchymal Stem Cells. Stem Cells. 2015;33:3315-3326. Wang X, Ge J, Tredget EE et al. The mouse excisional wound splinting model, including applications for stem cell transplantation. Nat Protoc. 2013;8:302-309. Wu Y, Zhao RC, Tredget EE. Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells. 2010;28:905-915. Chen L, Tredget EE, Wu PY et al. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PloS One. 2008;3:e1886. Wu Y*, Chen L, Scott PG et al. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007;25:2648-2659. Wu Y, Ip JE, Huang J et al. Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circulation Research. 2006;99:315-322. Wu Y, La Pierre DP, Wu J, Yee AJ, and Yang BB. (2005) The interaction of versican with its binding partners. Cell Res. 15: 483-94.