Smith, Michael B. - University of Connecticut

个人简介

NIH Postdoctoral Trainee, Massachusetts Institute of Technology, 1979 Ph.D. Purdue University B.S. Virginia Polytechnic Institute and State University

研究领域

Our current research involves total synthesis, drug design and the use of conducting polymers in green chemistry. We have synthesized an indocyanine green fluorescent dye that is linked to a nitroimidazole unit. This compound targets cancerous hypoxic tumors in mice, allowing the tumor to be imaged by a fluorescence detector. This work is done in collaboration with Professor Quing Zhu in the Department of Electrical and Computer engineering. In collaboration with Professor Frank Nichols at the UCONN Health Center, we are studying a series of lipids obtained from the dental pathogen Porphyromonas gingivalis, which are responsible for inflammatory responses in periodontal disease, and also trigger multiple sclerosis in mice. We have synthesized the various chiral diastereomers and biological assay will determine which dihydroceramide compounds are responsible for the biological effects. A medicinal chemistry study will follow to determine the structure-activity relationships of these compounds. In collaboration with Professor Gregory Sotzing (Chemistry) we are studying the role of additives with conducting polymers.

近期论文

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Saeid Zanganeh, Hai Li, Patrick D. Kumavor, Umar Alqasemi, Andres Aguirre, Innus Mohammad, Courtney Stanford, Michael B. Smith, and Quing Zhu "Photoacoustic imaging enhanced by ICG conjugated single wall carbon nanotubes" J. Biomed. Opt, 2013, , 096006-1-10. Younis Mohammad, Andres Aquirre, Liisa T. Kuhn, Yan Xu, Saeid Zanganeh, Quing Zhu, and Michael B. Smith "Indocyanaine Green bis(carboxylic acid): New derivatives with an Increased Flurosecent Yield" Dyes & Pigments, 2013, 99, 275-283. Yan Xu, Saeid Zanganeh, Innus Mohammad, Andres Aguirre, Tianheng Wang, Yi Yang, Michael Smith and Quing Zhu "Targeting Tumor Hypoxia with 2-Nitroimidazole-ICG Dye Conjugates" J. Biomed. Optics 2013, 18(6), 066009. Christopher Pavlik, Martha D. Morton, and Michael B. Smith "Polymer Mediated Pinacol Rearrangements" Synlett 2011,, 2191-2194. John G. D'Angelo, Abdullah Saleh, Martha Morton, Jesse Quinn, Kendra Redden, Rafal Mielguz, Christopher Pavlik, and Michael B. Smith "Synthesis of 3-Adeninyl And 3-Guaninyl-5-Hydroxymethyl-2-Pyrrolidinone Nucleosides " J. Org. Chem. 2011, 76, 5574-5583. Onorato, A.; Pavlik, C.; Invernale, M.A.; Berghorn, I.D.; Sotzing, G.A.; Smith, M.B. "Polymer Mediated Cyclodehydration of alditols and ketohexoses " Carbohydrate Res. 2011, 346, 1662-1670. Nrusingh C. Biswal, Christopher Pavlik, Michael B. Smith, Andres Aquirre, Liisa T. Kuhn, Yan Xu, Saeid Zanganeh, Liisa T. Kuhn, Kevin P. Claffey, and Quing Zhu "Imaging tumor hypoxia markers by near infrared fluorescence tomography" J ournal of Biomedical Optics 2011, 16(6), 066009-01 - 066009-08. Pavlik, C.; Biswal, N.; Gaenzler, F.C.; Morton, M.D.; Kuhn, LT.; Claffey, K.P.; .Zhu, Q.; Smith, M.B. 揝ynthesis and Florescent Characteristics of Imidazole-Indocyanine Green Conjugates ? Dyes & Pigments, 2010, 89, 9-15. Onorato, A.; Invernale, M.A.;Berghorn, I.D.; Pavlik, C.; Sotzing, G.A.; Smith, M.B. 揈nhanced Conductivity in Sorbitol-Treated PEDOT-PSS. Observation of an In Situ Cyclodehydration Reaction? Synth. Metals, 2010 160, 2284-2289. Faith Gaenzler, Chen (Lisa) Guo, Yun-Wei Zhang, Mohammad E. Azab, Mounir A.I. Salem, Dong Ping Fan, and Michael B. Smith ?2-Dienylphenacyloxazolones and an Intramolecular Diels-Alder Approach to the A-B-C Ring System of Phenanthridone Alkaloids,? Tetrahedron 2009, 65, 8781-8785. Christopher Pavlik, Amber Onorato, Steve Castro, Martha Morton, Mark Peczuh and Michael B. Smith 揂n Unexpectedly Facile Cyclization of Polyhydric Alcohols?, C, Org. Lett. 2009, 11, 3722-3725. Kozlov, Artem; Semenov, Vyacheslav; Mikhailov, Anatoliy; Aganov, Albert; Smith, Michael; Reznik, Vladimir; Latypov, Shamil "Preferential Protonation and Methylation Site of the Thiopyrimidine Derivatives in Solution. NMR Data" Journal of Physical Chemistry, B, 2008, 112(10), 3259-3267. JiYoung Mun, Amber Onorato, Frank C. Nichols*, Martha D. Morton, Abdullah I. Saleh, Morgan Welzel, and Michael B. Smith "Chemical Synthesis and Confirmation of the Dihydrosphinganine and Fatty Acid Constituents of the Dental Pathogen Porphyromonas gingivalis," Org. Biomol. Chem., 2007, 5, 3826-2833. John G. D'Angelo, Arvind Kumar, Amber Onorato, Christopher J. Delude, Gregory A. Sotzing,* and Michael B. Smith*, "Chemical Stability of Conducting Polymers: Friedel-Crafts Reactions of Alcohols With Poly(3,4-ethylenedioxythiophene) (PEDOT)," Polymer, 2007, 48, 4328-4336. Gaenzler, F.C.; Smith, M.B. "A Dichlorination/Reductive Dechlorination Route to N-Acetyl-2-Oxazolone" Synlett 2007, 1299-1301. D'Angelo, J.G.; Sawyer, R.; Kumar, A.; Onorato, A.; McCluskey, C.; Delude, C.; Vollenweider, L.; Reyes, N.; French, R.; Warner, S.; Chou, J.; Stenzel, J.; Sotzing, G.A.; Smith, M.B. 褾ormation Of Ethers By Reaction Of The Conducting Polymer Poly(3,4-Ethylenedioxythiophene) With Alcohols? J. Polymer Science, Part A, 2007, 45, 2328-2333. Mun, J.; Smith, M.B. "N-Benzyl-5-Hydroxy-3-Pyrrolidin-2-One By Hydrogen Peroxide Oxidation Of N-Benzyl-3-Phenylseleno-2-Pyrrolidinone", Synth. Commun., 2007, 37, 813-819. Nichols, F.C.; Riep, B.; Mun, J.; Morton, M.D.; Kawai, T.; Dewhirts, F.E.; Smith, M.B. "Structures And Biological Activities Of Novel Phosphatidylethanolamine Lipids Of Porphyromonas gingivalis" Journal of Lipid Research 2006, 47, 844-853. Mekheimer, R.A.; Sadek, K.U.; El-Nabi, H.A.A.; El-Hameid Mohamed, A.A.; Ebraheem, E.A.; Smith. M.B. "Fused Quinoline Heterocycles VI: Synthesis of 5H-1-Thia-3,5,6-Triazaaceanthrylenes and 5H-1-Thia-3,4,5,6-Tetraazaaceanthrylenes", J. Heterocyclic Chem., 2005, 42, 567-573. Nichols, F.C.; Riep, B.; Mun, J.; Morton, M.D.; Bojarski, M.T.; Dewhirst, F.E.; Smith, M.B. 襍tructures and Biological Activity of Phosphorylated Dihydroceramides of Porphyromonas gingivalis?, J. Lipid Res., 2004, 45, 2317-2330.