研究领域
Our research focuses on applications of bioanalytical chemistry, biocatalysis, nanobiotechnology, and medical diagnostics. Our philosophy is to apply our knowledge of chemistry and biology to the solution of some of the problems of our society. Our work pursues advances in bioanalytical and biological chemistry coupled with nanoscience as they impact on medical diagnostics, environmental health, and drug technologies. We have ongoing projects in nanotechnology-based bio?sensor arrays for in vitro sensing of toxicity, arrays for biomarkers for early cancer detection, carbon-nanotube cancer drug delivery vehicles, biocatalytic systems for energy production, and photosynthetic protein redox chemistry.
近期论文
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James F. Rusling, Gregory W. Bishop, Nhi Doan, and Fotios Papadimitrakopoulos, Feature Article: Nanomaterials and biomaterials in electrochemical arrays for protein detection, J. Materials Chem. B, 2014, 2, 12–30. (PMCID: PMC3878175)
Yun Zhang, Nikki Magdaong, Harry A. Frank, and James F. Rusling, Protein Film Voltammetry and Co-factor Electron Transfer Dynamics in Spinach Photosystem II Core Complex, Photosynthesis Research, 2014, 120, 153–167.
Gregory W. Bishop1 and James F. Rusling, Nanobioelectrochemistry: proteins, enzymes and biosensors, In M. V. Mirkin & S. Amemiya, Eds., Nanoelectrochemistry, in press (2014)
Brunah A. Otieno, Colleen E. Krause, Alina Latus, Baskhara V. Chikkaveeraiah, Ronaldo C. Faria and James F. Rusling. On-line Protein Capture on Magnetic Beads for Ultrasensitive Microfluidic Immunoassays of Cancer Biomarkers, Biosens. & Bioelectron., 2014, 53, 268–274. (PMCID: PMC3855669)
Nataliia Guz, Jan Halámek, James F. Rusling, Evgeny Katz, A Biocatalytic Cascade with Several Output Signals – Towards Biosensors with Different Levels of Confidence, Anal. Bioanal. Chem. 2014, 406, 3365-3370.
J. F. Rusling, C. Krause, B. Otieno, K. Kadimisetty, C. Tang, A. Vaze, and G. Bishop. Versatile Low-cost Modular Microfluidic Arrays for Cancer Diagnostics. In Proceedings of the International Conference on Biomedical Electronics and Devices, 2014, 72-76. PMCID: PMC3775520
Boya Song, Shenmin Pan, Chi Tang, Dandan Li, James F. Rusling, Voltammetric Microwell Array for Oxidized Guanosinein Intact ds-DNA , Anal. Chem., 2013, 85, 11061–11067. (PMCID: PMC3856883)
James F. Rusling, Perspective: Multiplexed Electrochemical Protein Detection and Translation to Personalized Cancer Diagnostics, Anal. Chem. 2013, 85, 5304−5310. (PMCID: PMC3674208)
Colleen E. Krause, Brunah A. Otieno, Alina Latus, Ronaldo C. Faria, Vyomesh Patel, J. Silvio Gutkind, and James F. Rusling. Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins using Disposable Inkjet-printed Gold Nanoparticle Arrays, ChemistryOpen, 2013, 2, 141 – 145. (PMCID: PMC3775520)
Vyomesh Patel, Daniel Martin, Ruchika Malhotra, Christina A. Marsh, Colleen L. Doçi, Cherie-Ann O Nathan, Uttam K. Sinha, Bhuvanesh Singh, Alfredo A. Molinolo, James F. Rusling, J. Silvio Gutkind, Identification of DSG3 as a Biomarker for the Detection of Occult Metastasis in Sentinel Lymph Nodes in Oral Cancer Patients. Oral Oncology, 2013, 49, 93-101. (PMCID: PMC3546158)
Dhanuka P. Wasalathanthri, Spundana Malla, Itti Bist, Chi K. Tang, Ronaldo C. Faria, and James F. Rusling, High-Throughput Metabolic Genotoxicity Screening with a Fluidic Microwell Chip and Electrochemiluminescence, Lab on a Chip, 2013, 13, 4554 – 4562, (PMCID: PMC3901045)
Vigneshwaran Mani, Karteek Kadimisetty, Spundana Malla, Amit A. Joshi, and James F. Rusling, Paper-based Electrochemiluminescent Screening for Genotoxic Chemicals in the Environment, Environ. Sci. & Technol., 2013, 47, 1937−1944. (PMCID: PMC3578158)
Yixian Wang, Kaan Kececi, Michael V. Mirkin, Vigneshwaran Mani, Naimish Sardesai and James F. Rusling, Quantitative Resistive-Pulse Measurements with Nanopipettes: Detection of Au Nanoparticles and Nanoparticle-Bound Anti-peanut IgY, Chemical Science 2013, 4, 655-663. (PMCID: PMC3753817)
Vyomesh Patel, Daniel Martin, Ruchika Malhotra, Christina A. Marsh, Colleen L. Doçi, Cherie-Ann O Nathan, Uttam K. Sinha, Bhuvanesh Singh, Alfredo A. Molinolo, James F. Rusling, J. Silvio Gutkind, Identification of DSG3 as a Biomarker for the Detection of Occult Metastasis in Sentinel Lymph Nodes in Oral Cancer Patients. Oral Oncology, 2013, 49, 93-101. (PMCID: PMC3546158)
Vigneshwaran Mani, Karteek Kadimisetty, Spundana Malla, Amit A. Joshi, and James F. Rusling, Paper-based Electrochemiluminescent Screening for Genotoxic Chemicals in the Environment, Environ. Sci. & Technol., 2013, in press. (PMCID: PMC3578158)
Yixian Wang, Kaan Kececi and Michael V. Mirkin, Vigneshwaran Mani, Naimish Sardesai and James F. Rusling, Quantitative Resistive-Pulse Measurements with Nanopipettes: Detection of Au Nanoparticles and Nanoparticle-Bound Anti-peanut IgY, Chemical Science 2013, 4, 655-663. NIHMSID #450329
James F. Rusling and John B. Schenkman, High-throughput enzyme biocolloid systems for drug metabolism and genotoxicity profiling using LC-MS/MS. in Pablo Steinberg (ed.), High-Throughput Enzyme Biocolloid Systems For Drug Metabolism And Genotoxicity Profiling Using LC-MS/MS, John Wiley & Sons, 2013, in press.
Linlin Zhao, Besnik Bajrami, and James F. Rusling, Rapid LC-MS Drug Metabolite Profiling Using Bioreactor Particles, In Ian R. Phillips, Elizabeth A. Shephard, and Paul R. Ortiz de Montellano, Cytochrome P450 Protocols, Humana Press, 2013, in press
Naimish P. Sardesai, Karteek Kadimisetty, Ronaldo Faria, James F. Rusling, A microfluidic electrochemiluminescent device for detecting multiple cancer biomarker proteins, Anal. Bioanal. Chem. 2013, in press. PubMed # 23307128 NIHMSID #434925
Ruchika Malhotra, Vyomesh Patel, Bhaskara V. Chikkaveeraiah, Bernard S. Munge, Sok Ching Cheong, Rosnah B. Zain, Mannil T. Abraham, Dipak K. Dey, J. Silvio Gutkind, James F. Rusling, Oral Cancer Detection in the Clinic Using an Ultrasensitive Microfluidic Array for a Panel of Biomarker Proteins, Anal. Chem., 2012, 84, 6249–6255;(PMCID: PMC3418660)
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