Drennan, Catherine L - Massachusetts Institute of Technology

研究领域

Biological/Environmental/Inorganic/Physical

近期论文

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Grell, T. A., Goldman, P. J., & Drennan, C. L. (2014). SPASM and Twitch Domains in AdoMet Radical Enzyme Structures. Journal of Biological Chemistry, jbc-R114. Full text at JBC.org Setser, J. W., Heemstra Jr, J. R., Walsh, C. T., & Drennan, C. L. (2014). Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase. Biochemistry, 53(38), 6063-6077. Full text at ACS Publications Wei, Y., Funk, M. A., Rosado, L. A., Baek, J., Drennan, C. L., & Stubbe, J. (2014). The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proceedings of the National Academy of Sciences, 111(36), E3756-E3765. Full text at PNAS Liu, D. S., Nivón, L. G., Richter, F., Goldman, P. J., Deerinck, T. J., Yao, J. Z., … & Ting, A. Y. (2014). Computational design of a red fluorophore ligase for site-specific protein labeling in living cells. Proceedings of the National Academy of Sciences, 111(43), E4551-E4559. Full text at PNAS Funk, M. A., Judd, E. T., Marsh, E. N. G., Elliott, S. J., & Drennan, C. L. (2014). Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity. Proceedings of the National Academy of Sciences, 111(28), 10161-10166. Full text at PNAS Dowling, D. P., Bruender, N. A., Young, A. P., McCarty, R. M., Bandarian, V., & Drennan, C. L. (2013). Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nature Chemical Biology. doi:10.1038/nchembio.1426 Access the recommendation on F1000Prime Goldman, P. J., Grove, T. L., Booker, S. J., & Drennan, C. L. (2013). X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proceedings of the National Academy of Sciences,110(40), 15949-15954. Full text at PNAS Goldman, P. J., Grove, T. L., Sites, L. A., McLaughlin, M. I., Booker, S. J., & Drennan, C. L. (2013). X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proceedings of the National Academy of Sciences, 110(21), 8519-8524. Full text at PNAS Li, D., Fedeles, B. I., Shrivastav, N., Delaney, J. C., Yang, X., Wong, C., … & Essigmann, J. M. (2013). Removal of alkylation DNA adducts from N 2-alkylguanine and N 4-alkylcytosine by the adaptive response protein AlkB.Chemical research in toxicology. Full text at ACS Publications Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB. (2013) Metal Binding Properties of Escherichia coli YjiA, a Member of the Metal Homeostasis-Associated COG0523 Family of GTPases. Biochemistry 52 (10) 1788–1801. Full text at ACS Publications Kulik HJ and Drennan CL. (2013) Substrate Placement Influences Reactivity in Non-heme Fe(II) Halogenases and Hydroxylases. J. Biol. Chem. doi: 10.1074/jbc.M112.415570. Full text at JBC.org Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. (2013) Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proc. Natl. Acad. Sci. U.S.A. 110 (10) 3835–3840 Full text at PNAS Chang W-C, Dey M, Liu P, Mansoorabadi SO, Moon S, Zhao ZK, Drennan CL, Liu H-W. (2013) Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature 496, 114–118. Full text at Nature.com Brignole EJ, Ando N, Zimanyi CM, Drennan CL. (2013) The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years. Biochemical Society Transactions 40 523–530. Full text online. Li D, Delaney JC, Page CM, Yang X, Chen AS, Wong C, Drennan CL, Essigmann JM. (2012) Exocyclic Carbons Adjacent to the N6 of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB. J. Am. Chem. Soc. 134 (21) 8896–8901. Full text at ACS Publications Ando N, Kung Y, Can M, Bender G, Ragsdale SW, Drennan CL. (2012) Transient B12-Dependent Methyltransferase Complexes Revealed by Small-Angle X-ray Scattering. J. Am. Chem. Soc. 134 (43) 17945–17954. Full text at ACS Publications Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL. (2012) An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes. Chemistry & Biology 19, 855-865. Full text at Cell Press Aye Y, Brignole EJ, Long MJC, Chittuluru J, Drennan CL Asturias FJ, Stubbe J. (2012) Clofarabine Targets the Large Subunit (alpha) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers. Chemistry & Biology 19, 799-805. Full text at Cell Press Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL. (2012) Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase. Structure. 20 (8), 1374-1383. Full text at ScienceDirect Dowling DP, Vey JL, Croft AK, and Drennan CL. (2012) Structural diversity in the AdoMet radical enzyme superfamily. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics. 1824, 1178-1195. Full text at ScienceDirect