Leadbeater, Nicholas E. - University of Connecticut

个人简介

Cambridge University Research Fellow, 1996-1999 Ph.D. Cambridge University, U.K. B.Sc. (Hons), University of Nottingham, U.K.

研究领域

Use of microwaves in synthetic chemistry; organic synthesis in water; metal-mediated organic synthesis; clean synthesis; preparation of biofuels; physical organic chemistry; study of kinetics and mechanisms of organic reactions.

近期论文

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Desrosiers, J.-N.; Kelly, C. B.; Fandrick, D. R.; Nummy, L.; Campbell, S. J.; Wei, X.; Sarvestani, M.; Lee, H.; Sienkiewicz, A.; Sanyal, S.; Zeng, X.; Grinberg, N; Ma, S.; Song, J. J.; Senanayake, C. H. A Scalable and Regioselective Synthesis of 2-Difluoromethyl Pyridines from Commodity Chemicals, Organic Letters 2014, 17, 1724-1727. Leadbeater, N. E. Microwave Heating as a Tool for Organic Chemistry, Comprehensive Organic Synthesis, 2nd Edition 2014, 9, 234-286. Hamlin, T. A.; Kelly, C. B.; Cywar, R. M.; Leadbeater, N. E. Methylenation of Perfluoroalkyl Ketones using a Peterson Olefination Approach, Journal of Organic Chemistry 2014, 79, 1145-1155. Bobbitt, J. M.; Bartelson, A. L.; Bailey, W. F.; Hamlin, T. A.; Kelly, C. B. Oxoammonium Salt Oxidations of Alcohols in the Presence of Pyridine Bases, Journal of Organic Chemistry 2014, 79, 1055-1067. Leadbeater, N. E. Opening an Aladdin's cave: the Suzuki coupling in a room-temperature ionic liquid, Chemical Communications 2014, 50, 1515-1518. Stencel, L. M.; Leadbeater, N. E. Application of a new interface for rapid optimisation of bio-catalysed processes: proteolytic digestion and an enzyme-catalysed transesterification as examples, New Journal of Chemistry 2014, 38, 242-247. Hamlin, T. A.; Leadbeater, N. E. Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions, Beilstein Journal of Organic Chemistry 2013, 9, 1843-1852. Rudzinski, D. M.; Leadbeater, N. E. Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study, Green Processing and Synthesis 2013, 9, 323-328. Leadbeater, N. E. Microwave Heating and Continuous-Flow Processing as Tools for Metal-Catalyzed Couplings: Palladium-Catalyzed Suzkui-Miyaura, Heck, and Alkoxycarbonylation Reactions, Transition Metal-Catalyzed Couplings in Process Chemistry 2013, 279-298. Leadbeater, N. E. Approaches to the Scale-Up of Organic Chemistry using Microwave Heating, Scalable Green Chemistry 2013, 301-338. Kelly, C. B.; Mercadante, M. A.; Wiles, R. J.; Leadbeater, N. E. Oxidative Esterification of Aldehydes Using a Recyclable Oxoammonium Salt, Organic Letters 2013, 15, 2222-2225. Hamlin, T. A.; Kelly, C. B.; Leadbeater, N. E. Dehydrogenation of Perfluoroalkyl Ketones Using a Recyclable Oxoammonium Salt, European Journal of Organic Chemistry 2013, 3658-3661. Mercadante, M.; Kelly, C. B.; Bobbitt, J. M.; Tilley, L. J.; Leadbeater, N. E. Synthesis of 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate and 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl and their use in oxidative reactions, Nat. Protoc. 2013, 8, 666-676. Kelly, C. B. Synlett Spotlight No. 423 Synlett 2013, 24 , 527-528. Lee, C.; Pedrick, E. A.; Leadbeater, N. E. Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (η6-C6H5CH3)Cr(CO)3 as an Example, Journal of Flow Chemistry 2012, 2, 115-117. Mercadante, M. A.; Leadbeater, N. E. Development of methodologies for reactions involving gases as reagents: microwave heating and conventionally-heated continuous-flow processing as examples, Green Processing and Synthesis 2012, 1, 499-507. Anderson, N.; Gernaey, K. V.; Jamison, T. F.; Kircher, M.; Wiles, C.; Leadbeater, N. E.; Sandford, G.; Richardson, P. The challenges and benefits of flow chemistry to optimize drug development, Future Medicinal Chemistry 2012, 4, 1779-1789. Grewal, N. K.; Leadbeater, N. E. The central role of chemistry in 'quality by design' approaches to drug development, Future Medicinal Chemistry 2012, 4, 1799-1810. Kelly, C. B.; Mercadante, M. A.; Hamlin, T. A.; Fletcher, M. H.; Leadbeater, N. E. Oxidation of α-Trifluoromethyl Alcohols Using a Recyclable Oxoammonium Salt, Journal of Organic Chemistry 2012, 77, 8131-8141. Rudzinkski, D. M.; Kelly, C. B.; Leadbeater, N. E. A Weinreb amide approach to the synthesis of trifluoromethylketones, Chem. Commun. 2012, 48, 9610-9612.