Bezanilla, Francisco - University of Chicago - Department of Biochemistry & Molecular Biology

个人简介

Ph.D. in Biophysics, Catholic University, Santiago, Chile. Postdoctoral, Laboratory of Biophysics, NINDS, NIH and Dept. Physiology, Univ. of Rochester.

研究领域

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The main interest in the lab is the search for the dynamics of the molecular correlates of the function in membrane transport proteins. This is being approached with physical techniques such as temperature effects and complex capacitance measurements in the frequency domain combined with mutations of the molecule and assessed by gating currents, macroscopic currents and single molecule recordings. The correlation with structural changes are being monitored with optical techniques using real time fluorescence spectroscopy including lifetimes, changes in intensity and fluorescence resonance energy transfer from probes attached to strategic sites in the molecule of interest while being functional in the membrane.