Howell, Amy R. - University of Connecticut

个人简介

Postdoctoral Research Fellow, Nottingham University, 1989 Postdoctoral Research Fellow, Northwestern University, 1988 Ph.D. University of Kentucky B.S. Wheaton College

研究领域

New synthetic methodology; preparation and reactivity of 2 alkylidene oxetanes and azetidines; approaches to unusual, strained heterocycles as templates for the synthesis of biologically interesting molecules; synthesis of glyco?sphingolipids for examination of their role in immuno?modulation; preparation and biological activity of novel nucleosides.

近期论文

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“A Rapid Fluorescence-based Assay for Classification of iNKT Cell Activating Glycolipids," Arora, P.; Venkataswamy, M. M.; Baena, A.; Bricard, G.; Li, Q.; Veerapen, N.; Ndonye, R.; Park, J. -J.; Lee, J. H.; Seo, K. -C.; Howell, A. R.; Chang, Y. -T.; Illarionov, P. A.; Besra, G. S.; Chung, S. -K.; Porcelli, S. A. J. Am. Chem. Soc. 2011, accepted for publication. "A Molecular Basis for the Exquisite CD1d-restricted Antigen-specificity and Functional Responses of Natural Killer T Cells,” Wun, K. S.; Cameron, G.; Patel, O.; Pang, S. S.; Pellicci, D. G.; Sullivan, L. C.; Keshipeddy, S.; Young, M. H.; Uldrich, A. P.; Thakur, M. S.; Richardson, S. K.; Howell, A. R.; Illarionov, P. A.; Brooks, A. G.; Besra, G. S.; McCluskey, J.; Gapin, L.; Porcelli, S. A.; Godfrey, D. I.; Rossjohn, J. Immunity 2011, asap. “Mouse and Human iNKT Cell Agonist Beta-Mannosylceramide Reveals a Distinct Mechanism of Tumor Immunity,” O’Konek, J. J.; Illarionov, P.; Khursigara, D. S.; Ambrosino, E.; Izhak, L.; Castillo, B. F. II; Raju, R.; Khalili, M.; Kim, H. -Y.; Howell, A. R.; Besra, G. S.; Porcelli, S. A.; Berzofsky, J. A.; Terabe, M. J. Clin. Invest. 2011, 121, 683-694. "Alpha-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-inflammatory Agents ,” Bricard, G.; Venkataswamy, M. M.; Yu, K. O. A.; Im, J. S.; Ndonye, R. M.; Howell, A. R.; Veerapen, N.; Iliarionov, P. A.; Besra, G. S.; Li, Q.; Chang, Y.-T.; Porcelli, S. A. PLoS one 2010, 5, e14374. "Unexpected Cleavage of 2-Azido-2-(hydroxymethyl)oxetanes: Conformation Determines Reaction Pathway?" Farber, E.; Herget, J.; Gascon, J.; Howell, A. R.; J. Org. Chem. 2010, 75, 7565-7572. "A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity," Lombardi, V.; Stock, P.; Singh, A.; Kerzerho, J.; Yang, W.; Sullivan B. A.; Li, X.; Shiratsuchi, T.; Hnatiuk, N.; Howell, A. R.; Yu, K. O. A.; Porcelli, S. A.; Tsuji, M.; Kronenberg, M.; Wilson, B.; Akbari, O.; J. Immunol. 2010, 184, 2107-2115. "Design and Synthesis of an Activity-Based Probe Template for Protein Kinases," Keshipeddy, S.; Shi, Y.; Hnatiuk, N.; Morton, M.; Yao, X.; Howell, A. R.; Synlett 2010, 7, 1142-1144. "Adaptability of the Semi-Invariant Natural Killer T-cell Receptor Towards Structurally Diverse CD1d-Restricted Ligands" Joyce, S.; Florence, W. C.; Xia, C.; Gordy, L. E.; Chen, W.; Zhang, Y.; Scott-Browne, J.; Kinjo, Y.; Yu, K. O. A.; Keshipeddy, S.; Pellicci, D. G.; Patel, O.; Kjer-Nielsen, L.; McCluskey, J.; Godfrey, D. I.; Rossjohn, J.; Richardson, S. K.; Porcelli, S. A.; Howell, A. R.; Hayakawa, K.; Gapin, L.; Zajonc, D. M. EMBO J. 2009, 28, 3579-3590. "Recognition of Lyso-phospholipids by Human Natural Killer T Lymphocytes," Fox, L. M.; Cox, D. G.; Lockridge, J. L.; Wang, X.; Chen, X.; Scharf, L.; Trott, D.; Veerapen, N.; Ndonye, R. M.; Besra, G. S.; Howell, A. R.; Cook, M. E.; Adams, E. J.; Hildebrand, W. H.; Gumperz. J. E. PLoS Biol. 2009, 7, e1000228. "T Cell Receptor CDR2b and CDR3b Loops Collaborate Functionally to Shape the iNKT Cell Repertoire," Mallevaey, T.; Scott-Browne, J. P.; Matsuda, J. L.; Young, M. H.; Pellicci, D. G.; Patel, O.; Thakur, M.; Kjer-Nielsen, L.; Richardson, S. K.; Cerundolo, V.; Howell, A. R.; McCluskey, J.; Godfrey, D. I.; Rossjohn, J.; Marrack, P.; Gapin, L. Immunity 2009, 31, 60-71. “Synthesis and Evaluation of 3”- and 4”-Deoxy and -Fluoro Analogs of the Immunostimulatory Glycolipid, KRN7000,” Raju, R.; Castillo, B. F.; Richardson, S. K.; Thakur, M.; Severins, R.; Kronenberg, M.; Howell, A. R. Bioorg. Med. Chem. Lett. 2009, 19, 4122–4125. “Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T cell Activation,” Im, J. S.; Arora, P.; Bricard, G.; Molano, A.; Venkataswamy, M. M.; Baine, I.; Jerud, E. S.; Goldberg, M. F.; Baena, A.; Yu, K. O. A.; Ndonye, R. M.; Howell, A. R.; Yuan, W.; Cresswell, P.; Chang, Y. -T.; Illarionov, P. A.; Besra, G. S.; Porcelli, S. A. Immunity 2009, 30, 888-898. “Synthesis and Evaluation of an Acyl-chain Unsaturated Analog of the Th2 Biasing, Immunostimulatory Glycolipid, OCH,” Velmourougane, G.; Raju, R.; Bricard, G.; Im, J. S.; Besra, G. S.; Porcelli, S. A.; Howell, A. R. Bioorg. Med. Chem. Lett. 2009, 19, 3386-3388. "Cross Metathesis of alpha-Methylene-beta-lactams: The First Tetrasubstituted Alkenes by CM,” Liang, Y.; Raju, R.; Taylor, C. D.; Le, T.; Howell, A. R. Tetrahedron Lett. 2009, 50, 1020-1022. "Natural Killer T cell Autoreactivity Leads to a Specialized Activation State,"Wang, X.;Chen, X.; Rodenkirch, L.; Simonson, W.; Wernimont, S.; Ndonye, R. M.; Veerapen, N.; Gibson, D.; Howell, A. R.; Besra, G. S.; Painter, G. F.;Huttenlocher, A.; Gumprez, J. E. Blood, 2008, 112, 4128-4138. “Regulatory Roles for NKT Cell Ligands in Environmentally Induced Autoimmunity,” Vas, J.; Mattner, J.; Richardson, S. K.; Ndonye, R; Gaughan, J. P.; Howell, A. R.; Monestier, M. J. Immunol. 2008, 181, 6779-6788 "Natural Sphingomonas Glycolipids Vary Greatly in Their Ability to Activate Natural Killer T Cells" Kinjo, Y.; Pei, B.; Bufali, S.; Raju, R.; Richardson, S. K.; Imamura, M.; Fujio, M.; Wu, D.; Khurana, A.; Kawahara, K.; Wong, C.; Howell, A. R.; Seeberger, P. H.; Kronenberg, M. Chemistry & Biology, 2008, 15, 654-664 "A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR," Wun, K. S.; Borg, N. A.; Kjer-Nielsen, L.; Beddoe, T.; Koh, R.; Richardson, S. K.; Thakur, M.; Howell, A. R.; Scott-Browne, J. P.; Gapin, L.; Godfrey, D. I.; McCluskey, J.; Rossjohn, J. J. Exp. Med. 2008, 205, 939-949 “Alpha-S-GalCer: Synthesis and Evaluation for iNKT Cell Stimulation,” Blauvelt, M.; Khalili, M.; Jaung, W.; Wilson, S. B.; Paulsen, J.; Anderson, A. C.; Howell, A. R. Bioorg. Med. Chem. Lett. 2008, 18, 6374-6376 “Synthesis of epi-Oxetin via a Serine Derived 2-Methyleneoxetane,” Blauvelt, M.; Howell, A. R. J. Org. Chem. 2008, 73, 517-521