KAMAT, NEHA - Northwestern University - Department of Biomedical Engineering

个人简介

D.Phil., Bioengineering, University of Pennsylvania, Philadelphia, PA, October 2012 B.S., Bioengineering, Magna Cum Laude, Rice University, Houston, TX, May 2008

研究领域

Our interests lie in constructing minimal systems, or artificial cells, as a tool to understand and recreate certain cellular behaviors. We are specifically interested in designing mechanically responsive systems that can optically or enzymatically report membrane stress in biological and polymeric environments. By using emerging engineering methods in material science and synthetic biology, we aim to construct macromolecular assemblies that can coordinate both membrane biophysical processes and RNA-regulated chemical processes in order to continuously sense and respond to designed stimuli for medicinal and technological applications.

近期论文

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Jia, T. Z.; Fahrenbach, A. C.; Kamat, N. P.; Adamala, K. P.;Szostak, J. W. Oligoarginine Peptides Slow Strand Annealing and Assist Non-Enzymatic RNA Replication. Nature Chemistry 2016, advance online publication. Kamat, N. P.; Tobe, S.; Hill, I. T.;Szostak, J. W. Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides. Angewandte Chemie 2015. Kamat, N. P.; Henry, S. J.; Lee, D.;Hammer, D. A. Single-Vesicle Patterning of Uniform, Giant Polymersomes into Microarrays. Small 2013, 9, 2272-2276. Kamat, N. P.; Liao, Z.; Moses, L. E.; Rawson, J.; Therien, M. J.; Dmochowski, I. J.;Hammer, D. A. Sensing Membrane Stress with near Ir-Emissive Porphyrins. Proceedings of the National Academy of Sciences of the United States of America 2011, 108, 13984-13989. Kamat, N. P.; Lee, M. H.; Lee, D.;Hammer, D. A. Micropipette Aspiration of Double Emulsion-Templated Polymersomes. Soft Matter 2011, 7, 9863-9866. Kamat, N. P.; Robbins, G. P.; Rawson, J.; Therien, M. J.; Dmochowski, I. J.;Hammer, D. A. A Generalized System for Photoresponsive Membrane Rupture in Polymersomes. Advanced Functional Materials 2010, 20, 2588-2596.