JOHNSON, MARK - Northwestern University - Department of Biomedical Engineering

个人简介

Ph.D. Mechanical Engineering, MIT, Cambridge, MA M.S. Mechanical Engineering, MIT, Cambridge, MA B.S. Mathematics, Purdue University, West Lafayette, IN B.S. Interdisciplinary Engineering, Purdue University, West Lafayette, IN

研究领域

Dr. Johnson is internationally known for his work on ocular biomechanics, particular with regards to the pathogenesis of glaucoma and age-related macular degeneration. Studies in his group currently involve a bioengineering approach that utilizing perfusion studies, atomic force microscopy and theoretical analysis in combination with use of high-resolution morphometry and finite element modeling. Dr. Johnson has been involving in the study of a variety of physiological transport problems for the past 30 years including flow through the aqueous humor outflow pathways as relates to glaucoma, transport through the arterial wall, transport through the cornea, transport through macromolecular gels such as hyaluronic acid and Matrigel, and transport through Bruch’s membrane.

近期论文

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Curcio, CA, Johnson, M, Rudolf, M and Huang, J-D: The oil spill in ageing Bruch membrane, British Journal of Ophthalmology, 95:1638-1645, 2011. Cankova, Z, Huang, J-D, Kruth, HS and Johnson, M: Passage of low-density lipoprotein through Bruch's membrane and choroid, Experimental Eye Research, 93:947-955, 2012. Zhou, EN, Krishnan, R, Stamer, WD, Perkuman, K, Rejendran, K, Nabhan, JF, Lu, Q, Fredberg, JJ and Johnson, M: Mechanical responses of the endothelial cell of Schlemm's canal: Scope, variability and their potential role in controlling aqueous humor outflow, Journal of the Royal Society Interface, 9: 1144-1155, 2012. Vargas-Pinto, R, Gong, H and Johnson, M: The effect of the endothelial cell cortex on atomic force microscopy measurements, Biophysical Journal, 105:300-309, 2013. Overby, DR, Zhou,EH, Vargas-Pinto, R, Pedrigi, RM, Fuchshofer, R, Braakman, ST, Gupta, R, Perkumas,KM, Sherwood, JM, Vahabikashi, A, Dang, Q, Kim,JH, Ethier, CR, Stamer, WD, Fredberg, J and Johnson, M: Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma, Proceedings of the National Academy of Sciences, 111: 13876-13881, 2014. Yang, C-Y, Huynh, T, Johnson, M and Gong, H: Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes, Experimental Eye Research, 128: 27-33, 2014. Vargas-Pinto,R, Lai, J, Gong, H, Ethier,CR, Johnson, M: Finite element analysis of the pressure-induced deformation of Schlemm's canal endothelial cells, Biomechanics and Modeling in Mechanobiology, 14:851-863, 2015. Stamer, WD, Braakman, ST, Zhou, EH, Ethier, CR, Fredberg, JJ, Overby, DR, and Johnson, M: Biomechanics of Schlemm’s Canal Endothelium and Intraocular Pressure Reduction, Progress in Retinal and Eye Research, 44: 86-98, 2015. Park, C-Y, Zhou, EH, Tambe, D, Chen, B, Lavoie, T, Dowell, M, Simeonov, A, Maloney, DJ, Marinkovic, A, Tschumperlin, DJ, Burger, S, Frykenberg, M, Butler, JP, Stamer, WD, Johnson, M, Solway, J, Fredburg, JJ and Krishnan, R: High-throughput screening for modulators of cellular contractile force, in press, Integrative Biology, 2015. Johnson, M, McLaren, JW, and Overby, DR: Unconventional aqueous humor outflow: a review, in press in Experimental Eye Research, 2017.