BACKMAN, VADIM - Northwestern University - Department of Biomedical Engineering

个人简介

Ph.D. Medical Engineering and Medical Physics, Harvard University - MIT, Cambridge, MA M.S. Physics, MIT, Cambridge, MA M.S. Physics, St. Petersburg Polytechnic Institute, St. Petersburg, Russia B.S. Physics (Hons), St. Petersburg Polytechnic Institute, St. Petersburg, Russia

研究领域

Biophotonic; nanoscale imaging; physical biology of gene expression regulation; optical and molecular technologies for cancer diagnosis, and therapeutics; biophysics of cellular nanostructure and nanoenvironment; cancer biomarkers

近期论文

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L.M. Almassalha, A. Tiwari, P.T. Ruhoff, Y. Stypula-Cyrus, H. Matsuda, M.A. Dela Cruz, J.E. Chandler, C. White, C. Maneval, H. Subramanian, I. Szleifer, H. Roy, and V. Backman, “The global relationship between chromatin physical topology, fractal structure, and gene expression”, Scientific Reports, 7:41061, DOI: 10.1038/srep41061 (2017). R.K. Wali, N. Momi, M. Dela Cruz, A.H. Calderwood, Y. Stypula-Cyrus, L. Almassalha, A. Chhaparia, C.R. Weber, A. Radosevich, A.K. Tiwari, B. Latif, V. Backman and H.K. Roy, “Higher-order chromatin modulator cohesion SA1 is an early biomarker for colon carcinogenesis: race-specific implications”, Cancer Prevention Research, DOI: 10.1158/1940-6207.CAPR-16-0054 (2016). PMC5093027 J. Yi, Z. Puyang, L. Feng, L. Duan, P. Liang, V. Backman, X. Liu, and H. Zhang, “Optical detection of early damages in retinal ganglion cells in a mouse model of partial optic nerve crush injury”, IOVS, 57(13) 5665-5671 (2016). PMC5089219 G. Spicer, S. Azarin, J. Yi, S. Young, R. Ellis, G. Bauer, L. Shea, and V. Backman, “Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography”, Phys Med Biol. 61(19) 6892-6904 (2016). PMC5056859 W. Wu, A.J. Radosevich, A. Eshein, T.Q. Nguyen, J. Yi, L. Cherkezyan, H.K. Roy, I. Szleifer, V. Backman, “Using electron microscopy to calculate optical properties of biological samples”, Biomedical Optics Express 7(11), 4749-4762 (2016). PMC5119613 L.M. Almassalha, G.M. Bauer, J. Chandler, S. Gladstein, L. Cherkezyan, Y. Stypula-Cyrus, S. Weinberg, D. Zhang, P. Thusgaard Ruhoff, H. Roy, H. Subramanian, N. Chandel, I. Szleifer, V. Backman, “Label-free imaging of the native, living cellular nano-architecture using partial-wave spectroscopic microscopy”, PNAS, 113(42) E6372-E6381 (2016). PMC5081614. T. Swain, J. Vega-Perkins, W. Oestreich, C. Triebold, E. DuBois, J. Henss, A. Baird, M. Siple, V. Backman, and L. Marcelino, “Coral bleaching response index: a new tool to standardize and compare susceptibility to thermal bleaching”, Global Change Biology, 22(7) 2475-88 (2016). MSID: 849498 H. Subramanian, P. Viswanathan, L. Cherkezyan, R. Iyengar, S. Rozhok, M. Verleye, J. Derbas, J. Czarnecki, H.K. Roy, V. Backman, “Procedures for risk-stratification of lung cancer using buccal nanocytology”, Biomedical Optics Express, 7(9) 3795-3810 (2016). PMC5030050. B.E. Urban, B. Dong, V. Backman, C. Sun, H.F. Zhang, “Subsurface super-resolution imaging of unstained polymer nanostructures”, Scientific Reports, 6, 28156; doi: 10.1038/srep28156 (2016). PMC4926209. D. Zhang, I. Capoglu, Y. Li, L. Cherkezyan, J. Chandler, G. Spicer, H. Subramanian, A. Taflove, and V. Backman, “FDTD-based optical microscopy simulation of dispersive media facilitates the development of optical imaging techniques”, JBO, 21(6): 65004 doi:10.1117/1.JBO.21.6.065004 (2016). PMC4901185. B. Dong, L. Almassalha, Y. Stypula-Cyrus, B.E. Urban, T.Q. Nguyen, C. Sun, H.F. Zhang, and V. Backman, “Super-resolution intrinsic fluorescence imaging of chromatin using native, unmodified nucleic acids for contrast”, PNAS, 113(35), 9716-9721 (2016). PMC5024634. J.E. Chandler, Y. Stypula-Cyrus, L. Almassalha, G. Bauer, L. Bowen, H. Subramanian, I. Szleifer, and V. Backman, “Colocalization of cellular nanostructure using confocal fluorescence and partial wave spectroscopy”, Journal of Biophotonics, 1-8, doi: 10.1002/jbio.201500298 (2016). PMC5112146 P. Pradhan, D.J. Park, I. Capoglu, H. Subramanian, D. Damania, L. Cherkezyan, A. Taflove, V. Backman, “Enhancing the sensitivity of mesoscopic light reflection statistics in weakly disordered media by interface reflections”, International Journal of Modern Physics B, 30(23), 1650155 (2016). MSID: 849492 L.M. Almassalha, G.M. Bauer, J. Chandler, S. Gladstein, I. Szleifer, H.K. Roy, and V. Backman, “The greater genomic landscape: the heterogeneous evolution of cancer”, Cancer Research, doi: 10.1158/0008-5472.CAN-16-0585 (2016). PMC5084919. B. Dong, L. Almassalha, B.E. Urban, T.Q. Nguyen, S. Khuon, T.L. Chew, V. Backman, C. Sun, H.F. Zhang, “Super-resolution spectroscopic microscopy via photon localization”, Nature Communications, 7:12290 doi: 10.1038/ncomms12290 (2016). PMC4962472. J. Chandler, L. Cherkezyan, H. Subramanian, V. Backman,“Nanoscale refractive index fluctua tions detected via sparse spectral microscopy”, Biomedical Optics Express, 7(3), 883-893 (2016). T.D. Swain, E. DuBois, A. Gomes, V.P. Stoyneva, A.J. Radosevich, J. Henss, M.E. Wagner, E. Velazquez, J. Traub, B.J. Kennedy, C.M. Janczak, A.A. Grigorescu, M.W. Westneat, K. Sanborn, S. Levine, M. Schick, G. Parsons, J.D. Rogers, V. Backman, L.A. Marcelino, “Skeletal light scattering decreases bleaching susceptibility of reef-building corals”, BMC Ecol., 16(1) (2016). PMC4800776 Q. Miao, J. Derbas, A. Eid, H. Subramanian, V. Backman, “Automated cell selection using support vector machine for application to spectral nanocytology”, BioMed Research International, 2016(3), 1-10 (2016). PMC4745312 D. Zhang, L. Cherkezyan, I. Capoglu, H. Subramanian, J. Chandler, S. Thompson, A. Taflove, V. Backman, “Spectroscopic microscopy can quantify the statistics of subdiffractional refractive index fluctuations in media with random rough surfaces”, Optics Letters, 40(21), 4931-4934 (2015). J. Yi, Y. Stypula-Cyrus, C.S. Blaha, H.K. Roy, V. Backman, “Fractal characterization of chromatin decompaction in live cells”, Biophysical Journal, 109(11), 2218-2226 (2015). PMC4675813 L. Cherkezyan, D. Zhang, H. Subramanian, A. Taflove, V. Backman, “Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy”, JBO, 21(2), 025007 (2016). PMC4756051 N. Momi, V. Backman, C. Brendler, H.K. Roy, “Harnessing novel modalities: field carcinogenesis detection for personalizing prostate cancer management”, Future Oncology, 11, 2737-41 (2015) B.E. Urban, B. Dong, Z. Zhang, V. Backman, C. Sun, H.F. Zhang, “Super-resolution two-photon microscopy via scanning patterned illumination”, Physical Review E, 91(4):042703 (2015). PMC4565794 A.J. Radosevich, N.N. Mutyal, A. Eshein, T.Q. Nguyen, B. Gould, J. Rogers, M. Goldberg, L. Bianchi, V. Konda, D. Rex, E. Yen, J. Van Dam, H.K. Roy, V. Backman, “Rectal optical markers for in vivo risk stratification of premalignant colorectal lesions”, Clinical Cancer Research, 21(19), 4337-55 (2015). PMC4592390 J. Yi, W. Liu, S. Chen, N. Sheibani, C.M. Sorenson, A.A. Fawzi, V. Backman, R.A. Linsenmeier, H.F. Zhang, “Visible-light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation”, Light: Science and Application, 4, e334 (2015). PMC4674267