Basu, Ashis K. - University of Connecticut

个人简介

B.Sc. Chemistry (Honors) University of Calcutta, Calcutta, India 1971 M.Sc. Organic Chemistry University of Calcutta, Calcutta, India 1973 Ph.D. Bioorganic Chemistry Wayne State University, Detroit, MI 1984 Postdoc Chemical Toxicology MIT, Cambridge, MA 1984-1990

研究领域

Mechanism of action of the antitumor drug mitomycin C. Investigation of the mechanism of mutagenesis and repair of the DNA damages derived from γ radiation, oxidation, and environmental pollutants such as nitrated pyrenes that are suspected to pose threats to human health. A primary goal of this work is to define the relationship between the structure and three-dimensional effects of a solitary lesion in DNA and the mutagenicity, toxicity, and DNA repair that it may induce. We address various mechanistic details as to how the differences in organisms, DNA polymerases, and repair proteins may influence the biological outcome of a lesion.

近期论文

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Jasti, V., Das, R.S., Hilton, B.A., Weerasooriya, S., Zou, Y., and Basu, A.K. (2011) (5'S)-8,5'-cyclo-2'-deoxyguanosine is a strong block to replication, potent pol V-dependent mutagenic lesion, and is inefficiently repaired in Escherichia coli. Biochemistry 50, 3862-3865. [pdf] Raychaudhury, P. and Basu, A.K. (2011) Genetic requirement for mutagenesis of G[8,5-Me]T cross-link in Escherichia coli: DNA polymerases IV and V compete for error-prone bypass. Biochemistry 50, 2330-2338. [pdf] Basu, A.K. (2010) Mutagenesis: The outcome of faulty replication of DNA. Chapter 17 in: "Chemical Carcinogenesis" (Penning, T., ed) Springer, New York. pp 375-400. Basu, A., Broyde, S., Iwai, S., and Kisker, C. (2010) DNA damage, mutagenesis, and DNA repair (editorial). Journal of Nucleic Acids Article ID 182894, 1 page, 2010. doi:10.4061/2010/182894. [pdf] Raychaudhury, P. and Basu, A.K. (2010) Replication past the γ-radiation-induced guanine-thymine cross-link G[8,5-Me]T by human and yeast DNA polymerase η. Journal of Nucleic Acids Article ID 101495, 10 pages, 2010. doi:10.4061/2010/101495. [pdf] Weng, M.-w., Zheng, Y., Jasti, V.P., Champeil, E., Tomasz, M., Wang, Y., Basu, A.K., and Tang, M.-s. (2010) Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acids Res. 38, 6976-6984. [pdf] Brown, K.L., Roginskaya, M., Zou, Y., Altamirano, A., Basu, A.K., and Stone, M.P. (2010) Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: Destabilization of two base pairs at the lesion site. Nucleic Acids Res. 38, 428 - 440. [pdf] Brown, K.L., Roginskaya, M., Zou, Y., Altamirano, A., Basu, A.K., and Stone, M.P. (2010) Structural consequences of epimerization of thymine glycol lesions in duplex DNA: Implications for DNA repair. Structural Biology of DNA Damage and Repair, Chapter 2, pp 11-28. ACS Symposium Series, Volume 1041. [pdf] Brown, K.L., Basu, A.K., and Stone, M.P. (2009) The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with dG in DNA. Biochemistry 48, 9722-9733.[pdf] Sherrer, S.M., Brown, J.A., Pack, L.R., Jasti, V.P., Fowler, J.D., Basu, A.K., and Suo, Z. (2009) Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. J. Biol. Chem. 284, 6379-6388. [pdf] Colis, L.C., Chakraborti, D., Hilario, P., McCarty, C., and Basu, A.K. (2009) Synthesis of oligonucleotides containing 2'-deoxyguanosine adducts of nitropyrenes. Nucleosides, Nucleotides, and Nucleic Acids 28, 67-77.[pdf] Colis, L.C., Raychaudhury, P., and Basu, A.K. (2008) Mutational specificity of γ-radiation-induced guanine-thymine and thymine-guanine intrastrand cross-links in mammalian cells and translesion synthesis past the guanine-thymine lesion by human DNA polymerase η. Biochemistry 47, 8070-8079. [pdf] Brown, K.L., Adams, T., Jasti, V.P., Basu, A.K., and Stone, M.P. (2008) Interconversion of the cis-5R,6S- and trans-5R,6R-thymine glycol lesions in duplex DNA. J. Am. Chem. Soc. 130, 11701-11710. [pdf] Tolentino, J.H., Burke, T.J., Mukhopadhyay, S., McGregor, W.G. and Basu, A.K. (2008) Inhibition of DNA replication fork progression and mutagenic potential of 1, N6-ethenoadenine and 8-oxoguanine in human cell extracts. Nucleic Acids Res. 36, 1300-1308. [pdf] Tolentino_NAR_2008.pdf Watt, D.L., Utzat, C.D., Hilario, P., and Basu, A.K. (2007) Mutagenicity of the 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in mammalian cells. Chem. Res. Toxicol. 20, 1658-1664. [pdf] Yang, Z., Roginskaya, M., Colis, L.C., Basu, A.K., Shell, S.M., Liu, Y., Musich, P.R., Harris, C.M., Harris, T.M. and Zou, Y. (2006) Specific and efficient binding of XPA to double-strand/single-strand DNA junctions with 3'- and 5'-ssDNA branches. Biochemistry 45, 15921-15930. [pdf] Ocampo-Hafalla, M.T., Chan, M.K., Altamirano, A., Basu, A.K., Cummings, Jr., A., Boorstein, R.J., Cunningham, R.P., and Teebor, G.W. (2006) Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization. DNA Repair 5, 444-454.[pdf] Kalam, M.A., Haraguchi, K., Chandani, S., Loechler, E.L., Moriya, M., Greenberg, M.M., and Basu, A.K. (2006) Genetic Effects of Oxidative DNA Damages: Comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res. 34, 2305-2315.[pdf] Yang, Z., Colis, L.C., Basu, A.K., and Zou, Y. (2005) Recognition and incision of γ-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease. Chem. Res. Toxicol. 18, 1339-1346. [pdf] Kalam, M.A. and Basu, A.K. (2005) Mutagenesis of 8-oxoguanine adjacent to an abasic site in simian kidney cells: Tandem mutations and enhancement of G→T transversions. Chem. Res. Toxicol. 18, 1187-1192. [pdf]