Angeles-Boza, Alfredo - University of Connecticut

个人简介

Postdoc: Johns Hopkins University, 2009-2012 Postdoc: Texas A&M University, 2008-2009 Ph.D Texas A&M University, 2002-2007 Pontificia Universidad Católica del Perú, Lima, Perú, 2000

研究领域

We are devoted to the use of synthetic inorganic chemistry as a tool to design and construct new molecules for targeted applications. Our research efforts are centered in two key areas: 1) the development of molecular chemistry of consequence to CO2 conversion to higher-energy products and 2) the design and synthesis of compounds with medicinal properties that take advantage of the important role of metal ions in biological systems. Our approach involves synthesizing novel complexes and characterizing them with an arsenal of physical, chemical and spectroscopic data.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

“Competitive Oxygen-18 Kinetic Isotope Effects Expose O−O Bond Formation in Water Oxidation Catalysis by Monomeric and Dimeric Ruthenium Complexes” Angeles-Boza, A. M.; Ertem, M. Z.; Sarma, R.; Ibanez, C. H.; Maji, S.; Llobet, A.; Cramer, C. J.; Roth, J. P. Chem. Sci. 2014, 5, 1141-1152. “Experimental and Computational Evidence of Metal-O2 Activation and Rate-Limiting Proton-Coupled Electron Transfer in a Copper Amine Oxidase” Liu, Y.; Mukherjee, A.; Ozbil, M.; Brown, D.; Angeles-Boza, A. M.; Dooley, D. M.; Prabhakar, R.; Roth, J. P. J. Phys. Chem. B 2013, 134, 218-229. “Studies of Di-iron(VI) Intermediate in Ferrate-Dependent Oxygen Evolution from Water” Sarma, R.; Angeles-Boza, A. M.; Brinkley, D. W,; Roth, J. P. J. Am. Chem. Soc. 2012, 134, 15371-15386. “Oxygen Kinetic Isotope Effects upon Catalytic Water Oxidation by a Monomeric Ruthenium Complex” Angeles-Boza, A. M.; Roth, J. P. Inorg. Chem. 2012, 51, 4722-4729. “Experimental and Computational Investigations of Oxygen Reactivity in a Heme and Tyrosyl Radical-Containing Fatty Acid α-(Di)oxygenase” Huff, G. S.; Doncheva, I. S.; Brinkley, D.; Angeles-Boza, A. M.; Mukherjee, A.; Cramer, C. J,; Roth, J. P. Biochemistry 2011, 50, 7375-7389. “Catalytic Mechanism of a Heme and Tyrosyl Radical-Containing Fatty Acid α-(Di)oxygenase” Mukherjee, A.; Angeles-Boza, A. M.; Huff, G. S.; Brinkley, D.; Roth, J. P.J. Am. Chem. Soc. 2011, 133, 227-238. “Generation of Endosomolytic Reagents by Branching of Cell-Penetrating Peptides: Tools for the Delivery of Bioactive Compounds to Live Cells in Cis or Trans” Angeles-Boza, A. M.; Erazo-Oliveras, A.; Lee, Y.-J..; Pellois, J.-P. Bioconj. Chem. 2010, 21, 2164-2167. “Photophysical Properties, DNA Photocleavage, and Photocytotoxicity of a Series of Dppn Dirhodium(II,II) Complexes” Joyce, L. E.; Aguirre, J. D.; Angeles-Boza, A. M.; Chouai, A.; Fu, P. K.-L.; Dunbar, K. R.; Turro, C. Inorg. Chem. 2010, 49, 5371-5376. “Anticancer Activity of Heteroleptic Diimine Complexes of Dirhodium: A Study of Intercalating Properties, Hydrophobicity and in cellulo Activity” Aguirre, J. D.; Angeles-Boza, A. M.; Turro, C.; Pellois, J.-P.; Dunbar, K. R. Dalton Trans. 2009 (48), 10806 – 10812. “Live Cell Cytotoxicity Studies of Dirhodium Complexes: Documentation of Antitumor Active Dirhodium Compounds Interactions with Nuclear DNA” Aguirre, J. D.; Angeles-Boza, A. M.; Chouai, A.; Pellois, J.-P.; Turro, C.; Dunbar, K. R. J. Am. Chem. Soc. 2009, 131(1), 11353-11360. “Redox-Regulated Inhibition of T7 RNA Polymerase via Establishment of Disulfide Linkages by Substituted Dppz Dirhodium(II,II) Complexes” Aguirre, J. D.; Chifotides, H. T.; Angeles-Boza, A. M.; Chouai, A.; Turro, C.; Dunbar, K. R. Inorg. Chem. 2009, 48(10), 4435-4444. “Ultrafast Ligand Exchange: Detection of a Pentacoordinate Ru(II) Intermediate and Product Formation” Liu, Y.; Turner, D. B.; Singh, T. N.; Angeles-Boza, A. M.; Chouai, A.; Dunbar, K. R.; Turro, C. J. Am. Chem. Soc. 2009, 131(1), 26-27. “Effect of Axial Coordination on the Electronic Structure and Biological Activity of Dirhodium(II,II) Complexes” Aguirre, J. D.; Lutterman, D. A.; Angeles-Boza, A. M.; Dunbar, K. R.; Turro, C. Inorg. Chem. 2007, 46(18), 7494-7502. “Dirhodium (II,II) Complexes: Molecular Characteristics that Affect in Vitro Activity” Angeles-Boza, A. M.; Chifotides, H. T.; Aguirre, J. D.; Chouai, A.; Fu, P. K.-L.; Dunbar, K. R.; Turro, C. J. Med. Chem. 2006, 49(23), 6841-6847. “Photocytotoxicity of a New Rh2(II,II) Complex: Increase in Cytotoxicity upon Irradiation Similar to Hematoporphyrin” Angeles-Boza, A. M.; Bradley, P. M.; Fu, P. K.-L.; Shatruk, M.; Hilfiger, M.G.; Dunbar, K. R.; Turro, C. Inorg. Chem. 2005, 44(21), 7262-7264. “DNA Binding and Photocleavage in vitro by New Dppz Dirhodium(II,II) Complexes: Correlation to Cytotoxicity and Photocytotoxicity” Angeles-Boza, A. M.; Bradley, P. M.; Fu, P. K.-L.; Wicke, S. E.; Bacsa, J.; Dunbar, K. R., Turro, C. Inorg. Chem. 2004, 43(26), 8510-8519. “Direct DNA Photocleavage by a New Intercalating Dirhodium(II,II) Complex: Comparison to Rh2(μ-O2CCH3)4” Bradley, P. M.; Angeles-Boza, A. M., Dunbar, K. R., Turro, C. Inorg. Chem. 2004, 43(8), 2450-2452. “Structural Evidence for Monodentate Binding of Guanine to the Dirhodium(II,II) Core in a Manner Akin to that of Cisplatin” Chifotides, H. T.; Hess, J. S.; Angeles-Boza, A. M.; Galán-Mascarós, J. R.; Sorasaenee, K.; Dunbar, K. R. J. Chem. Soc., Dalton Trans. 2003 (23), 4426 – 4430. “Synthesis, Structures, and Conformational Characteristics of Calixarene Monoanions and Dianions” Hanna, T. A.; Liu. L.; Angeles-Boza, A. M.; Kou, X.; Gutsche, C. D.; Ejsmont, K.; Watson, W. H.; Zakharov, L. N.; Incarvito, C. D.; Rheingold, A. L. J. Am. Chem. Soc. 2003, 125(20), 6228-6238. “Inhibition of Transcription in Vitro by Anticancer Active Dirhodium(II) Complexes” Sorasaenee, K.; Fu, P. K.-L., Angeles-Boza, A. M., Dunbar, K. R., Turro, C. Inorg. Chem. 2003, 42(4), 1267-1271.