Litosh, Vladislav A. - University of Cincinnati

个人简介

Vladislav Litosh obtained his Ph.D. from Rice University working with Professor Edward Billups. His endeavor was focused on synthesis and characterization of small-ring species and investigation of their transformations and their reactivity toward metallacarbenes. Upon graduation, he carried out postdoctoral research with Professor Barry Sharpless at the Scripps Research Institute in California where he was involved in the development of a library of potential anthrax inhibitors using click-chemistry approach. Later, he joined LaserGen, Inc., a small start-up biotech company where working closely in a team with two other chemists, he developed a set of four base-modified reversible nucleotide terminators for DNA sequencing by synthesis. Then he joined the University of Illinois at Chicago as a visiting Research Assistant Professor, where he was leading the synthetic medicinal chemistry team in Professor Thatcher’s laboratory focused on the development of calpain inhibitors and sGC activators as potential therapeutics for Alzheimer’s disease, modification of SERM (Selective Estrogen Receptor Modulators) scaffolds for neuroprotection, and synthesis of quinomethide precursors for cancer chemoprevention

研究领域

The current research interests of the Litosh laboratory include the development of novel cancer chemotherapeutic agents at the interface of organic chemistry and nanotechnology, and the discovery of novel cysteine protease inhibitors with increased selectivity and enhanced efficiency. In addition, the Litosh group maintains collaborative effort with the Rubinstein group in the College of Medicine in search of improved drug candidates for acute myocardial infarction

近期论文

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B. P. Stupi, H. Li, J. Wang, W. Wu, S. E. Morris, V. A. Litosh, Jessie Muniz, M. N. Hersh, & M. L. Metzker (2012). Stereochemistry of Benzylic Carbon Substitution and Ring Modification of 2-Nitrobenzyl Groups as Key Determinants for Fast-Cleaving Reversible Terminators. Angew. Chem. Int. Ed., 51(7), 1724, 1727. [Link] L. B. Sagle, K. Cimatu, V. A. Litosh, Y. Liu, S. Flores, X. Chen, B. Yu, P. S. Cremer (2011). The Methyl Groups of Trimethylamine N-Oxide (TMAO) Orient Away from Hydrophobic Interfaces. J. Am. Chem. Soc., 133(46), 18707, 18712. [Link] R., Abdelhamid, J. Luo, L. VandeVrede, I. Kundu, B. Michalsen, V. A. Litosh, I. T. Schiefer, T. Gherezghiher, P. Yao, Z. Qin, G. R. J. Thatcher (2011). Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPR30-Dependent Mechanism. ACS Chem. Neurosci., 2(5), 256, 268. [Link] V. A. Litosh, W. Wu, B. P. Stupi, J. Wang, S. E. Morris, M. N. Hersh, M. L. Metzker (2011). Improved Nucleotide Selectivity and Termination of 3'-OH Unblocked Reversible Terminators by Molecular Tuning of 2-Nitrobenzyl Alkylated HOMedU Triphosphates. Nucleic Acids Res., 39(6), e38. [Link] L. B. Sagle, Y. Zhang, V. A. Litosh, X. Chen, Y. Cho, P. Cremer (2009). Investigating the Hydrogen Bonding Model of Urea Denaturation. J. Am. Chem. Soc., 131(26), 9304, 9310. [Link] W. Wu, B. P. Stupi, V. A. Litosh, D. Mansouri, S. Morris, S. Metzker, & M. L. Metzker (2007). Termination of DNA Synthesis by N6-alkylated, not 3'-O-alkylated, Photocleavable 2'-Deoxyadenosine Triphosphates. Nucleic Acids Res., 35(19), 6339, 6349. [Link] W. E. Billups, R. K. Saini, V. A. Litosh, L. B. Alemany, W. K. Wilson, & K. B. Wiberg (2002). Thermal Rearrangements of Spiro[2.4]hepta-1, 4, 6-trienes. J. Org. Chem., 67(13), 4436, 4440. [Link] H. F. Bettinger, A. D. Rabuck, G. E. Scuseria, N. X. Wang, V. A. Litosh, R. K. Saini, & W. E. Billups (2002). Pathways for the Thermally Induced Dehydrogenation of C60H2. Chem. Phys. Lett., 360(5), 509, 514. [Link] V. A. Litosh, R. K. Saini, I. Y. Guzman-Jimenez, K. H. Whitmire, & W. E. Billups (2001). Reactions of Cycloproparenes with Metal Carbenes. Organic Lett., 3(1), 65, 66. [Link] R. K. Saini, V. A. Litosh, A. D. Daniels, & W. E. Billups (1999). Synthesis of 1, 4-Dichlorospiropentadiene. Tetrahedron Lett., 40(34), 6157, 6158. [Link] W. E. Billups, V. A. Litosh, R. K. Saini, & A. D. Daniels (1999). Synthesis of Oxaspiropentene. Organic Lett., 1(1), 115, 116. [Link] V. A. Litosh, R. K. Saini, A. D. Daniels, & W. E. Billups (1999). Synthesis and Characterization of 1-Chloro-3-methylenecyclopropene. Tetrahedron Lett., 40(7), 1261, 1264. [Link] F. Sun, A. Kosterev, G. Scott, V. A. Litosh, & R. F. Curl (1998). "v1 and v1+v5 of DCCN: Determination of the v5 Energy and the Quasilinearity of DCCN. J. Chem. Phys., 109(20), 8851, 8856. [Link] N. B. Grigor'ev, M. A. Kalinkina, G. V. Chechekin, V. B. Nikitin, G. N. Engal'cheva, N. N. Belushkina, V. L. Levina, I. L. Dalinger, M. D. Mashkovskii, S. A. Shevelev, V. A. Litosh, M. V. Vener, I. S. Severina, M. E. Kaminka, A. P. Arzamastsev, & V. G. Granik (1998). N-Nitropyrazoles as a Novel Class of Nitrogen Oxide Generators. Russ. J. Pharm. Chem., 32(3), 15, 19. [Link] I. L. Dalinger, V. A. Litosh, & S. A. Shevelev (1997). N-nitration of 3(5)-Substituted Pyrazoles. Russ. Chem. Bull., 46(6), 1149, 1153. [Link] T. Dunlap, S. C. Piyankarage, G. T. Wijewickrama, S. Abdul-Hay, M. Vanni, V. A. Litosh, J. Luo, & G. R. J. Thatcher (2012). Quinone-Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide. Chem. Res. Toxicol., 25(12), 2725, 2736. I. T. Schiefer, S. Tapadar, V. A. Litosh, M. Siklos, R. Scism, G. T. Wijewickrama, E. P. Chandrasena, V. Sinha, E. Tavassoli, M. Brunsteiner, M. Fa’, O. Arancio, P. Petukhov, and G. R. J. Thatcher, “Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors” J. Med. Chem. 2013, 56, 6054-6068. Purujit N. Gurjar, Aron P. Bercz, Thi N. Nguyen, Anish K. Vadukoot, Vladislav A. Litosh, “Cyclopropenes as Potential Warheads for Inhibitors of Cysteine Proteases” Univ. J. Chem. in press