Landero, Julio Alberto - University of Cincinnati

个人简介

BS, Autonomous University of Yucatan, Merida, Yucatan Mexico, 2004 (Industrial Chemistry). Ph.D., University of Guanajuato, Guanajuato Mexico, 2009 (Analytical Chemistry).

研究领域

In my Ph.D. studies as well as in my Postdoctoral fellowship I have been involved in the development and use of analytical chemistry methods directed to biologically relevant problems. The analysis of biomolecules by state-of-the-art techniques has taken me to a broad spectrum of fields, from plant analysis to proteomics experiments. As a postdoctoral fellow in the Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati my research was focused on the regulatory effects of cytokines on the zinc proteome of macrophage in response to Histoplasma capsulatum infection, by analyzing through chromatographically coupled to elemental and molecular mass spectrometric techniques. The search for clinically relevant biomarkers has also been an area of interest, and has been applied to serum of hypertensive patients, in the search of metalloproteins and non-metal containing proteins as putative biomarkers for ischemic or hemorrhagic stroke. The focus of my current research is the role of metals in biological systems, in particular, the relevance of zinc, copper, iron and manganese in host-pathogen interactions. These chemical elements are essential micro nutrients for both pathogenic organisms and the host, and because of that, they can play an important role in the virulence or defeat of the invasive microorganisms. We have studied this interactions and found evidence of nutritional immunity, the directed deprivation of elements (Zn) as a defense mechanism of immune cells (macrophages), against pathogens at in vitro and in vivo models. By using metallomics schemes, we perform chromatographic separations with elemental specific ICP-MS or molecular structural ESI-IT-MSMS detectors to identify the metal containing species involved in this phenomenon. Our research interest extends beyond the nutritional immunity to the functional role of high and low molecular mass metal-containing species in the virulence of extracellular bacteria. This includes the signaling and activation of important excreted molecules, like proteases and linkage adherence factor proteins that can help the pathogens to avoid or survive the immune system attacks.

近期论文

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Julio A. Landero Figueroa, Kavitha Subramanian Vignesh, George S. Deepe, Jr. & Joseph Caruso (2014). SELECTIVITY AND SPECIFICITY OF SMALL MOLECULE FLUORESCENT DYES/PROBES USED FOR THE DETECTION OF Zn2+ AND Ca2+ IN CELLS. Metallomics (2). Kayla G. Kinker, Aaron M. Gibson, Stacey A. Bass, Brandy P. Day, Jingyuan Deng, Mario Medvedovic, Julio A. Landero Figueroa, Gurjit K. Khurana Hershey, Weiguo Chen (2014). Overexpression of Dimethylarginine Dimethylaminohydrolase 1 Attenuates Airway Inflammation in a Mouse Model of Asthma. Plos One, 9(1), 1. Karthickeyan Chella Krishnan, Santhosh Mukundan, Julio A. Landero Figueroa, Joseph A. Caruso, & Malak Kotb (2014). Metal-Mediated Modulation of Streptococcal Cysteine Protease (SpeB) Activity and Its Biological Implications. Infection and Immunity. Saadawi R, Hachmoeller O, Winfough M, Hanley T, Caruso JA, Landero Figueroa JA (2014). The hookah series part 2: elemental analysis and arsenic speciation in hookah charcoals. J.Anal.At.Spectrom., 29(11), 2146. Hanley TA, Saadawi R, Zhang P, Caruso JA, Landero-Figueroa JA (2014). Separation of silver ions and starch modified silver nanoparticles using high performance liquid chromatography with ultraviolet and inductively coupled mass spectrometric detection. Spectrochimica Acta Part B: Atomic Spectroscopy, 100, 173. Vadukoot AK, AbdulSalam SF, Wunderlich M, Pullen ED, Landero-Figueroa J, Mulloy JC, Merino EJ (2014). Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells. Bioorganic & Medicinal Chemistry, 22(24), 6885. Jorge-Nebert LF, Gálvez-Peralta M, Landero Figueroa J, Somarathna M, Hojyo S, Fukada T, Nebert DW (2015). Comparing Gene Expression during Cadmium Uptake and Distribution: Untreated versus Oral Cd-Treated Wild-Type and ZIP14 Knockout Mice. Toxicological Sciences, 143(1), 26. Jiawei Gong, Morwena Solivio, Edward J. Merino, Joseph A. Caruso and Julio Landero-Figueroa. (2015) Developing ICP-MS/MS for the detection and determination of synthetic DNA-protein crosslink models via phosphorus and sulfur detection. Analytical and Bioanalytical Chemistry Pacheco P, Hanley T, Figueroa JL. (2014) Identification of proteins involved in Hg-Se antagonism in water hyacinth (Eichhornia crassipes). Metallomics Figueroa, J. A. L., Afton, S., Wrobel, K., Wrobel, K., & Caruso, J. A. (2007). Analysis of phytochelatins in nopal (Opuntia ficus): a metallomics approach in the soil-plant system. Journal of Analytical Atomic Spectrometry, 22 (8 ), 897-904. Subramanian Vignesh, K., Landero Figueroa, J. A., Porollo, A., Caruso, J. A., & Deepe, George S., Jr. (2013). Granulocyte macrophage-colony stimulating factor induced zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 (4 ), 697-710. Figueroa, J. A. L., Wrobel, K., Afton, S., Caruso, J. A., Corona, J. F. G., & Wrobel, K. (2008). Effect of some heavy metals and soil humic substances on the phytochelatin production in wild plants from silver mine areas of Guanajuato, Mexico. Chemosphere, 70 (11 ), 2084-2091. Maldonado Santoyo, M., Landero Figueroa, J. A., Wrobel, K., & Wrobel, K. (2009). Analytical speciation of mercury in fish tissues by reversed phase liquid chromatography-inductively coupled plasma mass spectrometry with Bi3+ as internal standard. Talanta, 79 (3 ), 706-711. Corrales Escobosa, A. R., Landero Figueroa, J. A., Gutierrez Corona, J. F., Wrobel, K., & Wrobel, K. (2009). Effect of Fusarium oxysporum f. sp. lycopersici on the degradation of humic acid associated with Cu, Pb, and Ni: an in vitro study. Analytical and Bioanalytical Chemistry, 394 (8 ), 2267-76. Rodriguez Flores, C., Landero Figueroa, J. A., Wrobel, K., & Wrobel, K. (2009). ICP-MS multi-element profiles and HPLC determination of furanic compounds in commercial tequila. European Food Research and Technology, 228 (6 ), 951-958. Corrales Escobosa, A. R., Wrobel, K., Landero Figueroa, J. A., Gutierrez Corona, J. F., & Wrobel, K. (2010). Effect of Fusarium oxysporum f. sp lycopersici on the Soil-to-Root Trans location of Heavy Metals in Tomato Plants Susceptible and Resistant to the Fungus. Journal of Agricultural and Food Chemistry, 58 (23 ), 12392-12398. Wrobel, K., Landero Figueroa, J. A., Zaina, S., Lund, G., & Wrobel, K. (2010). Phosphorus and osmium as elemental tags for the determination of global DNA methylation-A novel application of high performance liquid chromatography inductively coupled plasma mass spectrometry in epigenetic studies. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 878 (5-6 ), 609-614. Ortiz, J. G. M., Shang, J., Catron, B., Landero, J., Caruso, J. A., & Cartwright, I. L. (2011). A Transgenic Drosophila Model for Arsenic Methylation Suggests a Metabolic Rationale for Differential Dose-Dependent Toxicity Endpoints. Toxicological Sciences, 121 (2 ), 303-311. Qin, Z., Lai, B., Landero, J., & Caruso, J. A. (2012). Coupling transmission electron microscopy with synchrotron radiation X-ray fluorescence microscopy to image vascular copper. Journal of Synchrotron Radiation, 19 (11 ), 1043-1049. Kodali, P., Chitta, K. R., Figueroa, J. A. L., Caruso, J. A., & Adeoye, O. (2012). Detection of metals and metalloproteins in the plasma of stroke patients by mass spectrometry methods. Metallomics, 4 (10 ), 1077-1087.