Addepalli, Balu - University of Cincinnati

个人简介

Bala Addepalli is a Biochemist with broad research interests in analytical biochemistry, molecular biology, mass spectrometry (MS)-based characterization of proteins and nucleic acids. He described the type and nature of viral nucleic acids along with their protein coding potential during his PhD studies. His postdoctoral studies with Prof. Arthur Hunt had identified the existence of novel RNA processing endonuclease in plant polyadenylation apparatus besides unravelling the molecular characteristics of poly(A) polymerases and other key polyadenylation subunit factors. He joined with Prof. Patrick Limbach to develop MS-approaches for detection and quantification of mass-silent nucleoside modification, pseudouridine, and other posttranscriptional modifications in RNA. He was inducted into the faculty as Assistant Professor-Research at Department of Chemistry in August 2013.

研究领域

His research interests revolve around development of molecular tools, such as development of novel ribonucleases for sequencing nucleoside modifications (extra chemical groups attached to nucleosides - A, G, C, U) in RNA; understanding the biological significance of nucleoside (post-transcriptional) and amino acid (post-translational) modifications; gene characterization; and evolving viable in vivo approaches for understanding the basics of ribosome subunit assembly. Another area of interest is to explore the application of nucleoside modification biology for biotechnology purposes. He is also interested in developing mass spectrometry-based approaches for biomarker characterization that reflects an altered metabolic state or disease condition.

近期论文

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Addepalli B, Meeks LR, Hunt AG (2009) Evolutionary diversification of poly(A) polymerases in plants. PLoS ONE 4:e8082. DOI:10.1371/journal.pone.0008082 Zhang J, Addepalli B, Yun KY, Hunt AG, Xu R, Rao S, Li QQ, Falcone DL (2008) A polyadenylation factor subunit implicated in regulating oxidative stress responses in Arabidopsis thaliana. PLoS ONE 3: e2410-e2422. DOI:10.1371/journal.pone.0002410 Hunt AG, Xu R, Addepalli B, Rao S, Forbes KP, Meeks LR, Xing D, Mo M, Zhao H, Bandyopadhyay A, Dampanaboina L, Marion A, Von Lanken C, Li QQ (2008) Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of protein-protein interactions and gene expression profiling. BMC Genomics 9:220-235. DOI: 10.1186/1471-2164-9-220 Addepalli B, Hunt AG (2008) Ribonuclease activity is a common property of Arabidopsis CCCH-containing zinc finger proteins FEBS letters 582:2577-82. http://dx.doi.org/10.1016/j.febslet.2008.06.029 Addepalli B, Hunt AG (2008) Redox and heavy metal effects on the biochemical activities of an Arabidopsis polyadenylation factor subunit function. Archives of Biochemistry and Biophysics 473:88-95. http://dx.doi.org/10.1016/j.abb.2008.02.027 Addepalli B, Hunt AG (2008) The interaction between two Arabidopsis polyadenylation factor subunits involves an evolutionarily-conserved motif and has implications for the assembly and function of the polyadenylation complex. Protein and Peptide Letters 15:76-88. DOI: 10.2174/092986608783330431 Addepalli B, Hunt AG (2007) A novel endonuclease activity associated with the Arabidopsis ortholog of the 30 kDa subunit of cleavage and polyadenylation specificity factor. Nucleic Acids Research 35:4453-4463. DOI: 10.1093/nar/gkm457 Forbes KP, Addepalli B, Hunt AG (2006) An Arabidopsis Fip1 homolog interacts with RNA and provides conceptual links with a number of other polyadenylation factor subunits. Journal of Biological Chemistry 281:176-86. DOI: 10.1074/jbc.M510964200 Addepalli B, Xu R, Dattaroy T, Li B, Bass WT, Li QQ, Hunt AG (2006) Disease resistance in plants that carry a feedback-regulated yeast poly(A) binding protein gene. Plant Molecular Biology 61:383-97. DOI: 10.1007/s11103-006-0019-6 Addepalli B, Meeks LR, Forbes KP, Hunt AG (2004) Novel alternative splicing of mRNAs encoding poly(A) polymerases in Arabidopsis. Biochimica Biophysica Acta 1679: 117-128. http://dx.doi.org/10.1016/j.bbaexp.2004.06.001 Gholizadeh A, Kumar M, Balasubrahmanyam A, Sharma S, Narwal S, Lodha M L, Kapoor HC (2004) Antioxidant activity of antiviral proteins from Celosia cristata L. Journal of Plant Biochemistry & Biotechnology 13: 13-18. DOI: 10.1007/BF03263184 Narwal S, Balasubrahmanyam A, Sadhana P, Kapoor HC, Lodha ML (2001) A systemic resistance inducing antiviral protein with N-glycosidase activity from Bougainvillea xbuttiana. Indian Journal of Experimental Biology 39:600-603. ISSN: 0975-1009 (Online); 0019-5189 (Print) Cheriyath V, Balasubrahmanyam A, Kapoor HC (2001) Purification and characterization of 29k poly(A)-binding protein from chickpea (Cicer arietinum) epicotyls. Indian Journal of Biochemistry and Biophysics 38:258-262. ISSN:0975-0959 (Online); 0301-1208 (Print) Narwal S, Balasubrahmanyam A, Kapoor HC, Lodha ML (2001) Purification and properties of antiviral proteins from the leaves of Bougainvillea xbuttiana. Indian Journal of Biochemistry and Biophysics 38:342-347. ISSN:0975-0959 (Online); 0301-1208 (Print) Balasubrahmanyam A, Baranwal VK, Lodha ML, Varma A, Kapoor, HC (2000) P