Bearden, Shawn E. - Idaho State University - Department of Biological Sciences

个人简介

2000, Ph.D. Exercise Physiology, Florida State University, Tallahassee, FL 1996, M.S. Exercise Science and Health Promotion, George Mason University, Arlington, VA 1994, B.S. Education, Sports Medicine, University of Virginia, Charlottesville, VA 2001-2004, Postdoctoral Fellow, Cellular and molecular neurobiology, neurovascular interactions, Yale University School of Medicine, New Haven, CT

近期论文

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Rhodehouse BC, Mayo JN, Beard RS Jr, Chen CH, Bearden SE. Opening of the Blood-Brain Barrier before Cerebral Pathology in Mild Hyperhomocysteinemia. PLoS One. 2013 May 16;8(5):e63951. doi: 10.1371/journal.pone.0063951. Print 2013. PMID: 23696861 First demonstration that blood-brain barrier opening predates neurodegeneration and cognitive impairment in hyperhomocysteinemia. Rhodehouse BC, Erickson MA, Banks WA, Bearden SE. Hyperhomocysteinemic mice show cognitive impairment without features of Alzheimer's disease phenotype. Journal of Alzheimer's Disease. Jan 1;35(1):59-66, 2013. PMID: 23334704. Erratum in 2013;35(4):877 First studies to elucidate the relation between HHcy and the blood-brain barrier transporters for amyloid beta Beard RS, Reynolds JJ, Bearden SE. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine. Vascular Pharmacology, 56(3-4):159-167, 2012. PMID: 22285407 First demonstration of ionotropic-metabotropic glutamate receptor signaling in endothelium Chen CH, Beard RS, Bearden SE. Homocysteine impairs endothelial cell proliferation by activating metabotropic glutamate receptor 5. Microcirculation, 19(4):285-95, 2012. PMID: 22221504 Mayo JN, Beard RS, Price TO, Chen CH, Erickson MA, Ercal N, Banks WA, Bearden SE. Nitrative Stress in Cerebral Endothelium is Mediated by mGluR5 in Hyperhomocysteinemia. Journal of Cerebral Blood Flow and Metabolism, 32(5):825-834, 2012. PMID: 22186670