个人简介

Joined In: 1990 B.A., Cornell University Ph.D., UCLA (Joan Valentine) Postdoctoral Associate, UCLA School of Medicine Postdoctoral Fellow, MIT (Stephen Lippard)

研究领域

Chemical Biology/Inorganic

Bioinorganic Chemistry, Allostery in Gas Sensing Metalloproteins, Metallosensor design

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Su, Y.; Majtan, T.; Freeman, K.M.; Linck, R.C.; Ponter, S.; Kraus, J.P.; Burstyn, J.N. "Comparative Study of Enzyme Activity and Heme Reactivity in Drosophila melanogaster and Homo sapiens Cystathionine beta-Synthases." Biochemistry. 2013, 52(4), 741-751. Smith, A.T.; Marvin, K.A.; Freeman, K.M.; Kerby, R.L.; Roberts, G.P.; Burstyn, J.N. "Identification of Cys94 as the Distal Ligand to the Fe(III) Heme in the Transcriptional Regulator RcoM-2 from Burkholderia xenovorans". J. Biol. Inorg. Chem. 2012, 17, 1071-1082. Smith, A.T.; Su, Y.; Stevens, D.J.; Majtan, T.; Kraus, J.P.; Burstyn, J.N. "Effect of the Disease-Causing R266K Mutation on the Heme and PLP Environments of Human Cystathionine ?-Synthase". Biochemistry. 2012, 51 (32), pp 6360–6370. Santiago Cintrón, M.; Green, O.; Burstyn, J.N. "Ethylene Sensing by Silver(I) Salt-Impregnated Luminescent Films". Inorg. Chem. 2012, 51 (5), 2737–2746. Barr, I.; Smith, A. T.; Chen, Y.; Senturia, R.; Burstyn, J. N.; Guo, F. "Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing." Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 1919-1924. Smith, A.T.; Majtan, T.; Freeman, K.M.; Su, Y.; Kraus, J.P.; Burstyn, J.N. "Cobalt Cystathionine β-Synthase: A Cobalt-Substituted Heme Protein with a Unique Thiolate Ligation Motif". Inorg. Chem. 2011, 50, 4417-4427. Barr, I.; Smith, A.T.; Senturia, R.; Chen, Y.; Burstyn, J.N.; Guo, F. "DiGeorge Critical Region 8 (DGCR8) Is a Double-Cysteine-Ligated Heme Protein". J. Biol. Chem. 2011, 286, 16716-16725. Majtan, T., Freeman, K. M., Smith, A. T., Burstyn, J. N., Kraus, J. P. "Purification and characterization of cystathionine β-synthase bearing a cobalt protoporphyrin" Arch. Biochem. Biophys., 2011, 508, 25-30. Ostrowski, A. D., Deakin, S. J, Azhar, B., Miller, T. W., Francoleon, N., Cherney, M. M., Lee, A., Burstyn, J. N., Fukuto, J. M., Megson, I. L., Ford, P. C. "Nitric Oxide Photogeneration from trans-Cr(cyclam)(ONO)2+ in a Reducing Environment. Activation of Soluble Guanylyl Cyclase and Arterial Vasorelaxation" J. Med. Chem., 2010, 53, 715-722. Miller, T. W., Cherney, M. M., Lee, A. J., Francoleon, N. E., Farmer, P. J., Bruce King, S., Hobbs, A. J., Miranda, K. M., Burstyn, J. N., Fukuto, J. M. "The effects of nitroxyl (HNO) on soluble guanylyl cyclase activity: Interactions at ferrous heme and cysteine thiols" J. Biol. Chem., 2009, 284, 21788-21796. Marvin, K. A., Reinking, J. L., Lee, A. J., Pardee, K., Krause, H. M., Burstyn, J. N. "Nuclear receptors Homo sapiens Rev-erb beta and Drosophila melanogaster E75 are thiolate-ligated heme proteins, which undergo redox-mediated ligand switching and bind CO and NO" Biochemistry, 2009, 48, 7056–7071. Green, O., Gandhi, B. A., Burstyn, J. N. "Photophysical Characteristics and Reactivity of Bis(2,9-di-tert-butyl-1,10-phenanthroline)Cu(I)" Inorg. Chem., 2009, 48, 5704–5714. Lee, A. J., Clark, R. W., Youn, H., Ponter, S., Burstyn, J. N. "Guanidine Hydrochloride-Induced Unfolding of the Three Heme Coordination States of the CO-Sensing Transcription Factor, CooA" Biochemistry, 2009, 48, 6585-6597. Tseng, T. A., Burstyn, J. N. "Synthesis and DNA Cleavage Activity of a Bifunctional Intercalator-Linked Copper(II) Macrocycle" Chem. Commun., 2008, 6209-6211. Marvin, K. A., Kerby, R. L., Youn, H., Roberts, G. P., Burstyn, J. N. "The CO-activated transcription regulator RcoM-2 from Burkholderia xenovorans is a cysteine-ligated hemoprotein that undergoes a redox-mediated ligand switch" Biochemistry, 2008, 47, 9016-9028. Cherney, M. M., Pazicni, S., Frank, N., Marvin, K. A., Kraus, J. P., Burstyn, J. N. "Ferrous Human Cystathionine β-Synthase Loses Activity during Enzyme Assay Due to a Ligand Switch Process." Biochemistry, 2007, 46, 13199-13210. Gandhi, B. A., Green, O., Burstyn, J. N. "Facile Oxidation-Based Synthesis of Sterically Encumbered Four-Coordinate Bis(2,9-di-tert-butyl-1,10-phenanthroline)copper(I) and Related Three-Coordinate Copper(I) Complexes." Inorganic Chemistry 2007, 46, 3816-3825. Clark,R. W., Youn, H., Lee, A. J., Roberts, G. P., Burstyn, J. N. "DNA binding by an imidazole-sensing CooA variant is dependent on the heme redox state." Journal of Biological Inorganic Chemistry 2007, 12, 139-146. Pinkert, J. C., Clark, R. W., Burstyn, J. N. "Modeling proline ligation in the heme-dependent CO sensor, CooA, using molecule analogs." Journal of Biological Inorganic Chemistry 2006, 11, 642-650. Clark, R. W., Lanz, N. D., Lee, A. J., Kerby, R. L., Roberts, G. P., Burstyn, J. N. "Unexpected NO-dependent DNA binding by the CooA homolog from Carboxydothermus hydrogenoformans." Proceedings of the National Academy of Sciences USA, 2006, 103, 891-896.