Perez, Charles Rubert - DePaul University

研究领域

Supramolecular polymers are materials composed of monomeric units held together by non-covalent interactions (ionic, aromatic, hydrogen-bonding, hydrophobic effects, metal-ligand, host-guest chemistry, etc.). The polymerization process in which these monomeric units are attracted to each other is often referred to as self-assembly. Supramolecular polymers differ from typical synthetic polymers in that covalent bonds are not necessary for polymerization. Some of the advantages of supramolecular polymers include: the diversity of monomeric unit that can be used (small molecules, peptides, DNA, sugars. Etc.), their formation can be reversible and externally triggered by mild stimuli (salt, pH and/or temperature) and they have the potential to form highly ordered and complex supramolecular structures such as fibers, spheres, ribbons, sheets and tubes at the nanoscale level. Such materials have shown to have vast applications in the field of nanotechnology for regenerative medicine, drug delivery, electronics and coatings, among others. The Rubert lab will specialize in designing unique peptide sequences and small molecules as monomer units to promote the formation of functional supramolecular polymers for applications in cell culture, anti-bacterial properties and catalysis using aromatic (π-π and π-cation interactions), salt-bridges and metal-ligand interactions as the main driving force for self-assembly.

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E. Pazos, E. Sleep, C. M. Rubert Pérez, S. Lee, F. Tantakitti, S. Stupp, “Direct Nucleation and Growth of Highly Ordered Silver Nano-particles on Peptide Nanofibers. New Superstructures with Antimicrobial Properties” J. Am. Chem. Soc. 2016, 138, 5507-5510. C. M. Rubert Pérez, N. Stephanopoulos, S. Sur, S. Lee, C. Newcomb, S. Stupp, “The Powerful Functions of Peptide-based Bioactive Matrices for Regenerative Medicine.” Annals of Biomed. Eng. 2014, 43, 501-514. C.M. Rubert Pérez, L. A. Rank, J. Chmielewski, “Tuning the Thermosensitive Properties of Hybrid Collagen Peptide-Polymer Hydrogels.” Chem. Comm. 2014, 50, 8174-8176. J. Boekhoven, C.M. Rubert Pérez, S. Sur, A. Worthy, S.I. Stupp. “Dynamic Display of Bioactivity through Host-Guest Chemistry.” Angew. Chemie. 2013, 52, 12077-12080. D.E. Przybyla, C.M. Rubert Pérez, J. Gleaton, V. Nandwana, J. Chmielewski, “Hierarchical Assembly of Collagen Peptide Triple Helices into Curved Disks and Metal Ion-promoted Hollow Spheres.” J. Am. Chem. Soc. 2013, 135, 3418-3422 C.M. Rubert Pérez, D. Lopez-Pérez, J. Chmielewski, M. Lipton, “Small Molecule Oligomerization Inhibitors of Anthrax Protective Antigen.” Chem. Biol. Drug. Des. 2012, 79, 260-269. C. M. Rubert Pérez, A. Panitch, J. Chmielewski, “A Collagen Peptide-based Physical Hydrogel for Cell Encapsulation.” Macromol. Biosci. 2011, 11, 1426-1431.