Karver, Caitlin E. - DePaul University - Department of Chemistry

研究领域

Research in Karver's lab broadly focuses on the chemical biology, bioorganic and medicinal chemistry of enzymes implicated in disease states. The lab uses synthetic organic chemistry as well as biochemical techniques to study biological systems of therapeutic interest. One area of interest focuses on the development of probes to study caspase-1, a cysteine protease involved in autoimmune diseases and inflammatory cancers. Our current assay to study this enzyme uses a peptide-based fluorescent substrate with relatively slow kinetic properties. One project seeks to develop new small molecule fluorescent substrates with improved rates of reaction with caspase-1. A second project involves the synthesis of new inhibitors of caspase-1 based on known inhibitors in the literature as well as ones discovered in our lab. Another project involves the synthesis and analysis of binding properties of inhibitors of histone deacetylases (HDACs). HDACs are targets of anti-cancer therapeutics that contain a catalytic Zn(II) in the active site. Upon synthesis of inhibitors, the binding energetics of the interaction of the inhibitor with the catalytic Zn(II) are determined by Isothermal Titration Calorimetry in collaboration with Drs. Lihua Jin and Kyle Grice in the chemistry department.

近期论文

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Margaret Kawarski and Caitlin E. Karver “Lazaroids U83836E and U74389G are Potent, Time-dependent Inhibitors of Caspase-1” ChemMedChem manuscript in revisions Erin K. Gallagher, Caitlin E. Karver, Stephanie S. Lyngaas and Lihua Jin “Binding energetics of the histone deacetylase inhibitor suberoylanilide hydroxamic acid with zinc(II) and cobalt(II)” manuscript in preparation Caitlin E. Karver, Eric S. Molina, Erin T. Economos, Jonathan C. Fuentes, Socrates M. Kaitson, Samuel Kogan, Gemma Levi, Jill K. Marcus, Stacey Mei, Sean C. Reinsalu, Kathryn Rico, Magdalena M. Zuzek, and Gregory B. Kharas “Novel Copolymers of Styrene. 12. Halogen Ring-Substituted Methyl 2-Cyano-3-Phenyl-2-Propenoates” Journal of Macromolecular Science Part A: Pure and Applied Chemistry 2014, 51, 101-105 Stephanie M. Sanford, Divya Krishnamurthy, Caitlin E. Karver, Logan Walker, Chen-Ting Ma, Thomase D.Y. Chung, Eduard Sergienko, Nunzio Bottini, and Amy M. Barrios “pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays” Methods, 2014, 65, 165-174 Gautam Patel, Caitlin E. Karver, Ranjan Behera, Paul Guyett, Peter Edwards, Norma E. Roncal, Richard J. Sciotti, Kojo Mensa-Wilmot, and Michael P. Pollastri “Kinase scaffold repurposing for neglected disease drug discovery: A structure-activity relationship study of lapatinib analogs as anti-trypanosomal agents” Journal of Medicinal Chemistry, 2013, 56, 3820–3832 Rosario Diaz-Gonzalez, F. Matthew Kuhlmann, Cristina Galan-Rodriguez, Luciana Madeira da Silva, Manuel Saldivia, Caitlin E. Karver, Ana Rodriguez, Stephen M. Beverley, Miguel Navarro, Michael P. Pollastri “The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing” PLoS Neglected Tropical Diseases, 2011, 5, e1297 Caitlin E. Karver, Vanessa F. Ahmed, and Amy M. Barrios “Oxidative Inactivation of the Lymphoid Tyrosine Phosphatase Mediated by Both General and Active Site Directed NO Donors” Bioorganic and Medicinal Chemistry Letters, 2011, 21, 285-287 Caitlin E. Hubbard, Amy M. Barrios. “A Highly Efficient Route to Enantiomerically Pure L-N-Bz-Pmp(t-Bu)2-OH and incorporation into a peptide-based protein tyrosine phosphatase inhibitor” Bioorganic and Medicinal Chemistry Letters, 2008, 18, 679-681