Brooke, Joanna S. - DePaul University - Department of Biological Sciences

研究领域

Brooke's research examines infectious diseases in humans. Currently, there are two research tracks in her laboratory. The first track investigates the molecular mechanisms of an emerging worldwide opportunistic multidrug-resistant bacterial pathogen, Stenotrophomonas maltophilia. This bacterium is ubiquitous in nature and is commonly associated with respiratory infections in humans. Brooke is interested in looking at the genes of this organism and how they contribute to its ability to cause infection in humans. This bacterium is associated with a significant fatality: case ratio in susceptible individuals with compromised immune systems. A significant feature of this organism is its ability to form bacterial films (biofilms) on living and non-living surfaces. Biofilms of infectious bacteria are difficult to remove and can act as sources of infection. Current work in her laboratory explores how specific genes of S. maltophilia influence its formation of these films. The second track of research investigates the presence of potentially harmful bacteria on surfaces in clinical and non-clinical settings that can come in contact with humans.

近期论文

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Brooke, J.S. 2014. New strategies against Stenotrophomonas maltophilia: a serious worldwide intrinsically drug-resistant opportunistic pathogen. Expert Review of Anti-infective Therapy, 12(1):1-4. Brooke, J.S. 2012. Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clinical Microbiology Reviews. 25:2-41. Annand, J.W., Bajaj, N., Sheth, A., Burgess, J., and Brooke, J.S. 2009. Potential pathogens and effective disinfectants on public telephones at a large urban United States university. Journal of Environmental Health. 71(6):24-8, 48.