Smithrud, David B. - University of Cincinnati

个人简介

David Smithrud is currently an Associate Professor of Chemistry at the University of Cincinnati. He received his BS degree in chemistry at the University of Washington. From there, he attended the University of California, Los Angeles and received his PhD. Under the guidance of Prof. Diederich, he developed synthetic host-guest complexes; with special emphasis on the effect solvents have on complexation. He joined Prof. Benkovic&39;s group at the Pennsylvania State University. As a post-doctoral student and NIH fellow, he further investigated and exploited molecular recognition events through the development of catalytic antibodies. These studies included constructing phage display libraries of M13 and lambda bacteriophages, synthesizing haptens, and performing molecular cloning and kinetic analysis. He joined the Chemistry Department at UC. Our research group uses mimetic chemistry to investigate the intricate interplay that exist between functional groups at protein binding domains in order to determine the underlying forces that give proteins their unique ability to recognize molecules and to develop novel synthetic devices. This research has produced novel binding agents, cell transport agents, and compounds that bind the major groove of DNA.

研究领域

Molecular recognition; Cell transport; DNA binding agents; Peptidomimetics; Host-Guest chemistry; Catalysis; Synthesis

近期论文

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David B. Smithrud, Xiaoyang Wang, Pheruza Tarapore, and Shuk-mei Ho “Crown Ether Host-Rotaxanes as Cytotoxic Agents” J. Med. Chem. Lett., 2013, 4 (1), pp 27–31 Haque, F; Lunn, J.; Fang, H.; Smithrud, D.; Guo, P. X. “Real-Time Sensing and Discrimination of Single Chemicals Using the Channel of Phi29 DNA Packaging Nanomotor” ACS NANO, 2012, 6, 3251-3261. Wang X.; Smithrud,D. B. “Pt-rotaxanes as cytotoxic agents” Bioorg. Med. Chem. Lett., 2011, 21, 6880-6883. Wang Xiaoyang; Smithrud David B. “Pt-rotaxanes as cytotoxic agents” Bioorganic & Medicinal Chemistry Letters, 2011 Volume: 21 Issue: 22 Pages: 6880-6883 Wang, Xiaoyang, Zhu, Jing, & Smithrud, David B (2010). Synthesis and investigation of host-[2]rotaxanes that bind metal cations. The Journal of organic chemistry, 75(10), 3358-70. Zhu, Jing, McFarland-Mancini, Molly, Drew, Angela F, & Smithrud, David B (2009). Host-rotaxanes with oligomeric axles are intracellular transport agents. Bioorganic & medicinal chemistry letters, 19(2), 520-3. Zhu, Jing, House, Brian E, Fleck, Erin, Isaacsohn, Idit, Drew, Angela F, & Smithrud, David B (2007). A host-rotaxane derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide. Bioorganic & medicinal chemistry letters, 17(18), 5058-62. Wang, Xiaoyang, Bao, Xiaofeng, McFarland-Mancini, Molly, Isaacsohn, Idit, Drew, Angela F, & Smithrud, David B (2007). Investigation of the intracellular delivery of fluoresceinated peptides by a host-[2]rotaxane. Journal of the American Chemical Society, 129(23), 7284-93. Bao, Xiaofeng, Isaacsohn, Idit, Drew, Angela F, & Smithrud, David B (2007). Determining the binding and intracellular transporting abilities of a host-[3]rotaxane. The Journal of organic chemistry, 72(11), 3988-4000. Zhu, J.; Smithrud, D. B. "Host-Rotaxanes Model Proteins that Promote Ligand Association through a Favorable Change in Configurational Entropy". Org. Biomol. Chem. (2007), 5, 2992-2999. Zhu, J.; House, B.; Fleck, E.; Isaacsohn I.; Drew, A. F.; Smithrud, D. B. "A host-rotaxane derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide". Bioorg. Med. Chem. Lett. (2007), 17, 5058-5062. Wang, X.; Bao, X.; McFarland-Mancini, M.; Isaacsohn, I.; Drew, A. F.; Smithrud, D. B. "Investigation of the Intracellular Delivery of Fluoresceinated Peptides by a Host-[2]Rotaxane". J. Am. Chem. Soc. (2007), 129, 7284-7293. Bao, X.; Isaacsohn, I.; Drew, A. F.; Smithrud, D. B. "Determining the Binding and Intracellular Transporting Abilities of a Host-[3]Rotaxane". J. Org. Chem. (2007), 72, 3988-4000. Zhu, Jing, & Smithrud, David B (2007). Host-rotaxanes model proteins that promote ligand association through a favorable change in configurational entropy. Organic & biomolecular chemistry, 5(18), 2992-9. Bao, X.; Isaacsohn, I.; Drew, A. F.; Smithrud, D. B. "Determining the intracellular transport mechanism of a cleft-[2]rotaxane". J. Am. Chem. Soc. (2006), 128, 12229-12238. Bao, Xiaofeng, Isaacsohn, Idit, Drew, Angela F, & Smithrud, David B (2006). Determining the intracellular transport mechanism of a cleft-[2]rotaxane. Journal of the American Chemical Society, 128(37), 12229-38. Fotins, Juris, & Smithrud, David B (2005). Creation and investigation of protein-core mimetics with parallel and antiparallel aligned amino acids. The Journal of organic chemistry, 70(11), 4452-9. Smithrud, D. B.; Fotins, J. "Creation and investigation of protein-core mimetics with parallel and antiparallel aligned amino acids". J. Org. Chem. (2005), 70, 4452-4459. Dvornikovs, V.; House, B. E.; Kaetzel, M.; Dedman, J. R.; Smithrud, D. B. "Host-[2]Rotaxanes as Cellular Transport Agents". J. Am. Chem. Soc. (2003), 125, 8290-8301. Smukste, I.; House, B. E.; Smithrud, D. B. "Host-[2]Rotaxane: the Advantage of Converging Functional Groups for Guest Recognition". J. Org. Chem. (2003), 68, 2559-2571.