Sagle, Laura B - University of Cincinnati

个人简介

Laura Sagle received her Ph.D. from UCSD in 2006 working with Professor Floyd Romesberg at the Scripps Research Institute. Her PhD work involved the development of a new site‐selective folding technique using infrared probes in proteins. Dr. Sagle then did postdoctoral research with Professor Paul Cremer at Texas A&M University, which investigated the role of small molecule stabilizers and denaturants on protein‐mimetic polymers using microfluidics and sum frequency generation spectroscopy. From there, she carried out postdoctoral research with Professor Richard Van Duyne at Northwestern University. This work involved single nanoparticle tracking studies of solid supported bilayers, single nanoparticle LSPR biosensing, and incorporating LSPR and SERS substrates into microfluidic devices. Dr. Sagle joined the Chemistry Department at the University of Cincinnati in August of 2012 as an Assistant Professor.

研究领域

Single molecule protein folding using SERS, biosensing devices using protein-nanoparticle arrays (which will eventually be incorporated into microfluidic devices), and bionanomaterials using proteins as templates.

近期论文

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Sagle, L. B., Cimatu, K., Litosh, V. A., Liu, Y., Flores, S., Chen, X., Yu, B., & Cremer, P. S. (2011). "The Methyl Groups of Trimethylamine N-oxide (TMAO) Orient Away From Hydrophobic Interfaces." J. Am. Chem. Soc., 133(46), 18707. [Link] Cho, Younhee, Sagle, Laura, Iimura, Satoshi, Zhang, Yanjie, Kherb, Jaibir, Chilkoti, Ashutosh, Scholtz, J. Martin, & Paul S. Cremer (2009). “Hydrogen Bonding of ß-Spiral Structure is Stabilized in D2O”. J. Am. Chem. Soc., 131(42), 15188. [Link] Sagle, Laura B., Zhang, Yanjie, Litosh, Vladislav, Chen, Xin, Cho, Younhee & Cremer, Paul S. (2009). "Investigating the Hydrogen Bonding Model of Urea Denatuation". J. Am. Chem. Soc., 131(26), 9304. [Link] Cho, Younhee, Zhang, Yanjie, Carlson, Kim, Sagle, Laura, Chilkoti, A., & Cremer, P. S. (2008). "Effects of Hofmeister Anions on the Phase Transition Temperature of Elastin-Like Polypeptides". J. Phys. Chem. B, 112(44), 13765. [Link] Chen, Xin, Sagle, Laura B., & Cremer, Paul S. (2007). "Urea Oreintation at the Protein Surface". J. Am. Chem. Soc., 129(49), 15104. [Link] Zhang, Yanjie, Furyk, Steven, Sagle, Laura B., Cho, Younhee, Bergbreiter, David E. & Cremer, Paul S. (2007). "Effects of Hofmeister Anions on the LCSTs of PNIPAM as a Function of Molecular Weight". J. Phys. Chem. C, 111(25), 8916. [Link] Weinkam, Patrick, Zimmermann, Jörg, Sagle, Laura B., Matsuda, Shigeo, Dawson, Philip E., Wolynes, Peter G. & Romesberg, Floyd E. (2008). "Characterization of the Alkaline Transitions in Ferricytochrome c Using Carbon-Deuterium Infrared Probes". Biochemistry, 47(51), 13470. [Link] Sagle, Laura B., Zimmermann, Jörg, Dawson, Philip E., & Romesberg, Floyd E. (2006). "Direct and High Resolution Characterization of Cytochrome c Equilibrium Folding". J. Am. Chem. Soc., 128(44), 14232. [Link] Sagle, Laura B., Zimmermann, Jörg, Matsuda, Shigeo, Dawson, Philip E., & Romesberg, Floyd E. (2006). "Redox-Coupled Dynamics and Folding in Cytochrome c". J. Am. Chem. Soc., 128(24), 7909. [Link] Cremeens, Matthew E., Fujusaki, Hiroshi, Zhang, Yong, Zimmermann, Jörg, Sagle, Laura B., Matsuda, Shigeo, Dawson, Philip E., Straub, John E., & Romesberg, Floyd E. (2006). "Efforts Toward Developing Direct Probes of Protein Dynamics". J. Am. Chem. Soc., 128(18), 6028. [Link] Sagle, Laura B., Zimmermann, Jörg, Dawson, Philip E., & Romesberg, Floyd E. (2004). "A High Resolution Probe of Protein Folding". J. Am. Chem. Soc., 126(11), 3384. [Link] Paddock, M.L., Sagle, L., Tehrani, A., Beatty, J.T., Feher, G., Okamura, M. Y. (2003). "Mechanism of Proton Transfer Inhibition by Cd2+ Binding to Bacterial Reaction Centers: Determination of the pKa of Functionally Important Histidine Residues". Biochemistry, 42(32), 9626. [Link] Adelroth, P, Paddock, ML, Sagle, LB, Feher, G, & Okamura, MY (2000). "Identification of the Proton Pathway in Bacterial Reaction Centers: Both Protons Associated with Reduction of Q(B) to Q(B)H(2) Share a Common Entry Point". Proceedings of the National Academy of Sciences of the United States of America, 97(N24), 13086. [Link] Goldbeck, RA, Sagle, L, KimShapiro, DB, Flores, V, & Kliger, DS (1997). "Evidence for Heme-Heme Excitonic Coupling in the Soret Circular Dichroism of Hemoglobin". Biochemical and Biophysical Research Communications, 235(N3), 610. [Link] Laura B. Sagle, Laura Ruvuna, Julia Bingham, Chunming Liu, Paul S. Cremer, & Richard P. VanDuyne (2012). Single Plasmonic Nanoparticle Tracking Studies of Solid Supported Bilayers with Ganglioside Lipids. Journal of the American Chemical Society, 134(38), 15832. [Link] Sagle, Laura B., Ruvuna, Laura K., Ruemmele, Julia A., & Van Duyne, R. P. (2011). Advances In Localized Surface Plasmon Resonance Biosensing. Nanomedicine, 6(8), 1447. [Link] Sarah Unser, Ian Campbell, Debrina Jana, and Laura B. Sagle. Direct Glucose Sensing in the Physiological Range Through Plasmonic Nanoparticle Formation. Analyst 2015, 140(2), 590-599.