Merino, Eddie J. - University of Cincinnati

个人简介

Eddie Merino is a chemist with research interests in studying the interplay between oxidative stress, DNA damage, and cancer. After earning an undergraduate degree from the University of San Diego in 2000, he studied under the direction of Dr. Kevin M. Weeks at University of North Carolina, Chapel Hill. While there, his graduate research focused on DNA biosensors and nucleic acid footprinting methods. He received his PhD from UNC in 2005. He then took a postdoctoral position at the California Institute of Technology working with Professor Jacqueline K. Barton. While in Pasadena, he worked in the area of oxidative stress and the formation of mutations involved in cancers. This background has helped him become an expert at creating nucleic acid damaging agents and elucidiating novel nucleic acid structures that will be used in the fight against cancer. In 2008, he moved to his current position in Cincinnati.

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Borland KM, AbdulSalam SF, Solivio MJ et al: Base-modified thymidines capable of terminating DNA synthesis are novel bioactive compounds with activity in cancer cells. Bioorg. Med. Chem. 2015, ASAP. (Litosh Paper) Vadukoot AK, AbdulSalam SF, Wunderlich M, Pullen ED, Landero- Figueroa J, Mulloy JC, Merino EJ: Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells. Bioorg. Med. Chem. 2014, 22, 6885-6892. Amato E, Bankemper T, Kidney R, Do T, Onate A, Thowfeik FS, Merino EJ, Paula S, Ma L: Investigation of fluorinated and bifunctionalized 3- phenylchroman-4-one (isoflavanone) aromatase inhibitors. Bioorg. Med. Chem. 2014. on-line. Hufziger KT, Thowfeik FS, Charboneau DJ, Nieto I, Dougherty WG, Kassel WS, Dudley TJ, Merino EJ, Papish ET, Paul JJ. Ruthenium dihydroxybipyridine complexes are tumor-activated pro-drugs due to low pH and blue light induced ligand release. J. Inorg. Biochem. 2014, 130: 103-111. Bell-Horwath TR, Vadukoot AK, Thowfeik FS, Li G, Wunderlich M, Mulloy JC, Merino EJ: Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia. Bioorg. Med. Chem. Lett., 2013, 23: 2951-2954. Chitta KR, Landero JA, Caruso JA, Merino EJ: Selenium mediated arsenic toxicity modifies cytotoxicity, reactive oxygen species and phosphorylated proteins. Metallomics 2013, 5: 673-685. Chitta KR, Landero JA, Kodali P, Caruso JA, Merino EJ: Identification of selenium-containing proteins in HEK 293 kidney cells using multiple chromatographies, LC–ICPMS and nano-LC–ESIMS. Talanta 2013, 114: 25- 31. Jones AR, Bell-Horwath TR, Li G, Rollmann SM, Merino EJ: Novel oxidatively activated agents modify DNA and are enhanced by Ercc1 silencing. Chem. Res. Toxicol. 2012, 2012 25: 2542-2552. Solivio MJ, Nemera D, Sallans L, Merino EJ: DNA-protein crosslinks efficiently form via reactive oxygen species. Chem. Res. Toxicol., 2012, 25: 326–336. Li G, Bell T, Merino EJ: Oxidatively-activated DNA modifying agents for selective cytotoxicity. ChemMedChem, 2011, 6: 869-875. Alp O, Merino EJ, Caruso JA: Selenium effects on arsenic cytotoxicity and protein phosphorylation in human kidney cells using nanoLC-MS. Metallomics 2011, 3: 482-190. Solivio MJ, Joy TJ, Sallans L, Merino EJ: Copper generated reactive oxygen leads to formation of lysine-DNA adducts. J. Inorg. Biochem. 2010, 104:1000- 1005.