Wingett, Denise - Boise State University - Department of Biological Sciences

个人简介

B.S., Boise State University, Chemistry, 1986 Ph.D., Washington State University, Biophysics and Biochemistry, 1991 Postdoctoral Fellow, Washington State University, Microbiology Dept., 1992-1994 Research Assistant Professor, Neuroimmunology Dept., Portland VA Medical Center/Oregon Health Sciences University, 1994-1995 Medical Research Scientist, Boise VA Medical Center, 1998-2003 Affiliate Faculty, Div. of Gerontology and Geriatric Medicine, Univ. Washington School of Medicine, 2006-present

研究领域

IMMUNOLOGY, NANOBIOLOGY, AND THERAPUETIC INTERVENTIONS FOR HUMAN DISEASE

近期论文

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Wyatt CR, Wingett D, White JS, Buck CD, Knowles D, Reeves D, and Magnuson NS: Persistent infection of rabbits with bovine leukemia virus associated with development of immune dysfunction. J Virol 63 :4498-4506, 1989. Wingett D, Reeves R, and Magnuson NS: Stability changes in pim-1 proto-oncogene mRNA following mitogen stimulation of normal lymphocytes. J Immunol 147: 3563-3659, 1991. Wingett D, Reeves R, and Magnuson NS: Characterization of the testes-specific Pim-1 transcript in rat. Nucleic Acids Res 20: 3183-3189, 1992. Wingett D, Stone D, Davis WC, and Magnuson NS: Expression of the pim-1 proto-oncogene: Differential inducibility between alpha/beta and gamma/delta-T cells and B cells. Cell Immunol 162:123-130, 1995. Wingett D, and Magnuson NS: Pim-1 proto-oncogene expression in anti CD3 mediated T cell activation is associated with protein kinase C activation and is independent of raf-1. J Immunol 156: 549-557, 1996. Whitham RD, Wingett D, Wineman J, Mass M, Wegmann K, Vandenbark A, and Offner H: Treatment of relapsing autoimmune encephalomyelitis with T cell receptor V beta-specific antibodies when proteolipid protein is the autoantigen. J Neurosci Res 45: 104-116, 1996. Wingett D, Forcier K, and Nielson CP: Glucocorticoid-medicated inhibition of RANTES expression in human T lymphocytes. Febs Lett 398:308-311, 1996. Hoover DS, Wingett D, Zhang J, Reeves R, and Magnuson NS: Pim-1 protein expression is regulated by its 5’-untranslated region and translation initiation factor eIF-4E. Cell Growth Diff 8: 1371-1380, 1997. Wingett D, Vestal RE, Forcier K, Hadjokas N, and Nielson CP: CD40 is functionally expressed on human breast carcinomas: Variable inducibility by cytokines and enhancement of Fas-mediated apoptosis. Breast Cancer Res Treat 50: 27-36, 1998. Wingett D, Forcier K, and Nielson CP: Regulation of CD40L expression by cyclic AMP: Contrasting proinflammatory and inhibitory actions. Cell Immunol 192: 203-212, 1999. Wingett D, Forcier K, and Nielson CP: A role for CD99 in T cell activation. Cell Immunol 193:17-23, 1999. Nielson CP, and Wingett D: Endothelial cell and cAMP regulation of T cell CD40: Relevance of CaMKIV signaling. Immunol 105: 430-440, 2002. Wingett D, and Nielson CP: Cyclic AMP differentially modulates CD40L expression on human naive and memory CD4+ T cells. Biochem Pharm 64: 1169-1178, 2002. Wingett D, and Nielson CP: Divergence in NK cell and cyclic AMP regulation of T cell CD40L expression in asthmatic subjects. J Leuk Biol 74: 531-541, 2003. Nielson C, and Wingett D: Intensive care and invasive ventilation in the elderly patient, implications of chronic lung disease and comorbidities. Chron Respir Dis 1: 43-54, 2004. Matthies KGM, Hodzic A, and Wingett D: Differential regulation of soluble and membrane CD40L protein in T cells. Cell Immun 241: 47-58, 2006. Olson RD, Headley MB, Walsh GM, and Wingett D: In vitro and in vivo immuno-suppressive activity of a novel anthracycline, 13-deoxy, 5-iminodoxorubicin. International Immunopharmacology, 7: 734-743, 2007. Reddy KM, Feris K, Bell J, Wingett DG, Hanley C, and Punnoose A: Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems. Applied Physics Letters, 90: 213902, 2007. Hanley C, Layne J, Punnoose A, Reddy KM, Coombs I, Coombs A, Feris K, and Wingett D: Preferential killing of cancer cells and activated human T cells using zinc oxide nanoparticles, Nanotechnology, 19: 295103, 2008. Wang H, Wingett D, Engelhard ME, Feris K, Reddy KM, Turner P, Layne J, Hanley C, Bell J, Tenne D, Wang C, and Punnoose A: Fluorescent dye encapsulated ZnO particles with cell-specific toxicity for cancer treatment and bio-medical applications. Journal of Material Science: Materials in Medicine, 20: 11-22, 2009. Hanley C, Thurber, A, Hanna C, Punnoose A, Zhang J, and Wingett D: The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction. Nanoscale Research Letters, 4: 1409-1420, 2009. Feris K, Otto C, Tinker J, Wingett D, Punnoose A, Thurber A, Quinn B, Hanna C, and Pink A: Electrostatic interactions affect nanoparticle-mediated toxicity to the Gram negative bacterium Pseudomonas aeruginosa PAO1, Langmuir, 26: 4429-4436, 2010. Rasmussen JW, Martinez E, Louka P, and Wingett D: Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert Opinion on Drug Delivery, 7, 1063-1077, 2010. Zhang J, Thurber A, Tenne D, Rasmussen JW, Wingett D, Hanna C, and Punnoose A: Enhanced dye fluorescence in novel dye-ZnO nano-composites. Advanced Functional Materials, 20: 4358,2010. Thurber A, Wingett DG, Rasmussen JW, Layne J, Johnson L, Tenne DA, Zhang, J, Hanna CB, and Punnoose A: Improving the selective cancer killing ability of ZnO nanoparticles using Fe doping, Nanotoxicology, 6(4): 440-52, 2012.