个人简介

Hairong Guan is an organometallic chemist with research interests in synthetic inorganic and organic chemistry, catalysis, and reaction mechanisms. After earning a BS degree from Peking University in 2000, he joined the research group of Professor Jack Norton at Columbia University, where he studied ruthenium-catalyzed ionic hydrogenation of iminium and aziridinium cations. Upon completion of his Ph.D. in 2005, he took a postdoctoral fellow position in the laboratory of Professor Charles Casey at the University of Wisconsin-Madison. His research project in Wisconsin involved the development of iron-catalyzed hydrogenation reactions. He joined the faculty of the University of Cincinnati in 2007 as an Assistant Professor and was promoted to Associate Professor in 2012. He received a National Science Foundation CAREER Award in 2010 and was named an Alfred P. Sloan Research Fellow in 2013.

研究领域

synthetic inorganic/organic chemistry; reaction mechanisms; catalysis with transition metal complexes; small molecule activation; solar energy to fuels; biomass conversion

The research in our group is at the interface between inorganic chemistry and organic chemistry focusing on reaction mechanisms and new synthetic methodologies. We are primarily interested in utilizing inexpensive metals such as Cr, Fe, Co, Ni, and Cu for homogeneous catalysis. Currently, we are working on the following research projects: (1) nickel, cobalt, and iron complexes with POCOP-pincer, PNP-pincer, and related ligands for catalytic reduction of carbonyl functionalities (such as those in aldehydes, ketones, and CO2 ), isomerization of olefins, cross-coupling reactions, aldol reactions, etc.; (2) nickel-catalyzed umpolung of enones, enals, ynoates, and α,β-unsaturated imines as a strategy to synthesize 1,4-difunctionalized compounds; (3) secondary phosphine oxides as effective ligands for transition-metal-catalyzed reactions; (4) heterobimetallic complexes for catalytic hydrogenation and water-gas shift reactions; (5) iron-catalyzed hydrogenation of esters (P&G project); (6) mechanisms of hair coloring (P&G project).

近期论文

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Chakraborty, S.; Bhattacharya, P. Dai, H.; Guan, H. "Nickel and Iron Pincer Complexes as Catalysts for the Reduction of Carbonyl Compounds." Submitted. Wilson, G. L. O.; Abraha, M.; Krause, J. A.; Guan, H. "Reactions of Phenylacetylene with Nickel POCOP-Pincer Hydride Complexes Resulting in Different Outcomes from Their Palladium Analogues." Dalton Trans. 2015, 44, in press. [link] Fairweather, N. T.; Gibson, M. S.; Guan, H. "Homogeneous Hydrogenation of Fatty Acid Methyl Esters and Natural Oils Under Neat Conditions." Organometallics 2015, 34, 335-339. [link] Qu, S.; Dai, H.; Dang, Y.; Song, C.; Wang, Z.-X.; Guan, H. "Computational Mechanistic Study of Fe-Catalyzed Hydrogenation of Esters to Alcohols: Improving Catalysis by Accelerating Pre-catalyst Activation with a Lewis Base." ACS Catal. 2014, 4, 4377-4388. [link] Bhattacharya, P.; Krause, J. A.; Guan, H. "Activation of Dihydrogen and Silanes by Cationic Iron Bis(phosphinite) Pincer Complexes." Organometallics 2014, 33, 6113-6121. [link] Bhattacharya, P.; Krause, J. A.; Guan, H. "Mechanistic Studies of Ammonia Borane Dehydrogenation Catalyzed by Iron Pincer Complexes."J. Am. Chem. Soc. 2014, 136, 11153-11161. [link] Chakraborty, S.;† Dai, H.;† Bhattacharya, P.; Fairweather, N. T.; Gibson, M. S.; Krause, J. A.; Guan, H. "Iron-Based Catalysts for the Hydrogenation of Esters to Alcohols." J. Am. Chem. Soc. 2014, 136, 7869-7872 (†co-first author). [link] Adhikary, A.; Guan, H. Nickel-Catalyzed Cross-Coupling Reactions. In Pincer and Pincer-Type Complexes: Application in Organic Synthesis and Catalysis. Szabó, K. J.; Wendt, O. F., Eds.; Wiley-VCH: Weinheim, Germany, 2014; pp 117-147. [link] Chakraborty, A.; Guan, H. "Iron, dicarbonylhydro[(1,2,3,3a,7a-h)-4,5,6,7-tetrahydro-2-hydroxy-1,3-bis(trimethylsilyl)-1H-inden-1-yl] (Knölker’s complex)" e-Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons Ltd., 2014. [link] Adhikary, A.; Schwartz, J. R.; Meadows, L. M.; Krause, J. A.; Guan, H. "Interaction of Alkynes with Palladium POCOP-Pincer Hydride Complexes and Its Unexpected Relation to Palladium-Catalyzed Hydrogenation of Alkynes." Inorg. Chem. Front. 2014, 1, 71-82. [link] (invited paper) Rodrigo, S. K.; Powell, I. V.; Coleman, M. G.; Krause, J. A.; Guan, H. "Efficient and Regioselective Nickel-Catalyzed [2+2+2] Cyclotrimerization of Ynoates and Related Alkynes." Org. Biomol. Chem. 2013, 11, 7653-7657. [link] Chakraborty, S.; Patel, Y. J.; Krause, J. A.; Guan, H. "A Robust Nickel Catalyst for Cyanomethylation of Aldehydes: Activation of Acetonitile under Base-Free Conditions."Angew. Chem. Int. Ed. 2013, 52, 7523-7526.[link] Chakraborty, S.; Zhang, J.; Patel, Y. J.; Krause, J. A.; Guan, H. "Pincer-Ligated Nickel Hydridoborate Complexes: the Dormant Species in Catalytic Reduction of Carbon Dioxide with Boranes."Inorg. Chem. 2013, 52, 37-47.[link] (featured on cover) Rodrigo, S. K.; Guan, H. "Quick Installation of a 1,4-Difunctionality via Regioselective Nickel-Catalyzed Reductive Coupling of Ynoates and Aldehydes." J. Org. Chem. 2012, 77, 8303-8309.[link] Zhang, J.; Adhikary, A.; King, K. M.; Krause, J. A.; Guan, H. "Substituent Effects on Ni−S Bond Dissociation Energies and Kinetic Stability of Nickel Arylthiolate Complexes Supported by a Bis(phosphinite)-Based Pincer Ligand." Dalton Trans. 2012, 41, 7959-7968. [link] (New Talent Americas Issue) Chakraborty, S.; Patel, Y. J.; Krause, J. A.; Guan, H. "Catalytic Properties of Nickel Bis(phosphinite) Pincer Complexes in the Reduction of CO2 to Methanol Derivatives."Polyhedron 2012, 32, 30-34. (special issue on Metal Mediated Transformations of CO2) [link] Bhattacharya, P.; Guan, H. "Synthesis and Catalytic Applications of Iron Pincer Complexes."Comments Inorg. Chem. 2011, 32, 88-112. [link] (invited review) Bhattacharya, P.; Krause, J. A.; Guan, H. "Iron Hydride Complexes Bearing Phosphinite-Based Pincer Ligands: Synthesis, Reactivity, and Catalytic Application in Hydrosilylation Reactions."Organometallics 2011, 30, 4720-4729. [link] Huang, F.; Zhang, C.; Jiang, J.; Wang, Z.-X.; Guan, H. "How Does the Nickel Pincer Complex Catalyze the Conversion of CO2 to a Methanol Derivative? A Computational Mechanistic Study." Inorg. Chem. 2011, 50, 3816-3825.[link] Zhang, J.; Medley, C. M.; Krause, J. A.; Guan, H. "Mechanistic Insights into C-S Cross-Coupling Reactions Catalyzed by Nickel Bis(phosphinite) Pincer Complexes." Organometallics 2010, 29, 6393-6401. [link]