Caruso, Joseph A - University of Cincinnati

个人简介

Professor Caruso received his PhD from Michigan State University under the direction of Alexander Popov. After a one-year postdoctoral fellowship with J. J. Lagowski at The University of Texas - Austin, he joined the faculty of the University of Cincinnati as assistant professor of analytical chemistry. During this time he has authored or co-authored close to 400 scientific publications and presented over 325 invited lectures at universities and at scientific meetings.

研究领域

Professor Caruso’s research interests are trace elemental analysis by atomic spectrometric methods. The principle focus is plasma source mass spectrometry. His interests in this area are wide ranging from sample introduction to instrumentation and detection. A strong interest of the group continues to be chemical speciation with element specific detection followed by molecular mass spectrometry to achieve "metallomics" analysis. Application of these methods to discovering biomarkers in CSF, molecular level understandings of phytoremediating plants, the role of metal regulation in infectious diseases and to establish a better molecular level understanding of the selenium reduction of arsenic toxicity.

近期论文

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Yong Fang, Brittany Catron, Yaofang Zhang, Liyan Zhao, Joseph A. Caruso, Qiuhui Hu, “Distribution and in Vitro Availability of Selenium in Selenium-Containing Storage Protein from Selenium-Enriched Rice Utilizing Optimized Extraction,” J. Ag. Food Chem. (2010) DOI:10.1021/jf100934p Michael S. Winters, Qilin Chan, Joseph A. Caruso, George S. Deepe, “Metallomic Analysis of Macrophages Infected with Histoplasma capsulatum Reveals a Fundamental Role for Zn in Host Defenses,” J. Infect. Dis. (Sept. 2010), DOI: 10.1086/656191 Yaofang Zhang, Joseph Clark, Gail Pyne-Geithman, Joseph Caruso, “Metallomics study in CSF for putative biomarkers to predict cerebral vasospasm,” Metallomics, 2, 628-637 (August (2010). doi:10.1039/C0MT00005A Yaofang Zhang, Kevin M. Kubachka and Joseph A. Caruso, “Removal of Inorganic Phosphate to Enhance the Determination of Chemical Warfare Nerve Agent Degradation Products,” Anal. Methods, 2, 1243-1248 (2010), DOI: 10.1039/c0ay00230e Renee N. Easter, Karolin K. Kröning, Patrick A. Limbach, Joseph A. Caruso. "Separation and identification of oligonucleotides by novel hydrophilic interaction liquid chromatography (HILIC) - inductively coupled plasma mass spectrometry (ICPMS)," Analyst, 135, 2560-2565 (2010). Orkun Alp, Edward Merino, Joseph Caruso, “Arsenic induced protein phosphorylation changes in HeLa cells,”Anal. Bioanal. Chem., 398 (5), 2099-2107 (Nov 2010) DOI 10.1007/s00216-010-4128-3 Becker, Johanna; Breuer, Uwe; Hsieh, Hui-Fang; Osterholt, Tobias; Kumtabtim, Usarat; Qin, Zhenyu; Matusch, Andreas; Caruso, Joseph, "Bioimaging of metals and biomolecules in mouse heart by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and secondary ion mass spectrometry (SIMS)," Anal. Chem., 2010, 82, 9528–9533 (2010). S. B. Jayasinghe and J. A. Caruso, “Investigation of Se-containing proteins in Bertholletia excelsa H.B.K. (Brazil nuts) by ICPMS, MALDI-MS and LC-ESI-MS Methods,” Intn. J. Mass Spectrom. published, available on-line Dec. 16 (2010). Zhenyu Qin, Barry Lai, Andreas Matusch, J. Sabine Becker, Joseph Caruso, “Trace Metal Imaging with High Spatial Resolution: Applications in Biomedicine,” Metallomics, 3, 28-37 (Jan. 2011). Orkun Alp, Edward Merino, Joseph Caruso, “Selenium effects on arsenic cytotoxicity and protein phosphorylation in human kidney cells using nanoLC-Chip-ESIMS, Metallomics, DOI: 10.1039/c0mt00110d (2011). Yaofang Zhang, Richard L. Thompson, Joseph A. Caruso, “Probing the viral metallome: searching for metalloproteins in bacteriophage λ - the hunt begins,”Metallomics, 3, DOI: 10.1039/c0mt00104j (2011) S. B. Jayasinghe and J. A. Caruso, “Fractional precipitation by ammonium sulfate as a front-end sample fractionation and enrichment technique in metalloproteomics,” in revisionAnalytical Methods, (spring 2011). Heather R. Trenary, Patricia A. Creed, Andrea R. Young, Madhavi Mantha, Carol A. Schwegel, Jianping Xue, Michael J. Kohan, Karen Herbin-Davis, David J. Thomas, Joseph A, Caruso, John T. Creed, “An In Vitro Assessment of Bioaccessibility of Arsenicals in Rice,” in revision, Envir. Sci. Tech. (spring 2011). Jorge G. Muñiz Ortiz, Junjun Shang, Brittany Catron, Julio Landero, Joseph Caruso & Iain L. Cartwright, “A transgenic Drosophila model for arsenic methylation suggests a metabolic rationale behind chronic vs. acute toxicity endpoints,” accepted in press, Environ. Health Perspectives (March 2011). Scott E. Afton, David McNear, Joseph A. Caruso, “Exploring the structural basis for mercury/selenium antagonism in Allium fistulosum - green onion,” to be submitted Angew. Chemie, Intn. Ed. (2011). Kirk E. Lokits, Patrick A. Limbach, Joseph A. Caruso, “Development of a Selective Technique for Detecting Anti-sense Phosphorothioate Oligonucleotides by IPRP-ICPMS,” to be submitted, Anal. Bioanal. Chem. (2011).