Bobst, Albert M - University of Cincinnati

个人简介

Dr. Albert M. Bobst is a Professor of Chemistry and Biological Chemistry at the University of Cincinnati. After receiving his PhD at the University of Zurich in 1965, where he synthesized, and characterized Tetrahydropterins by nuclear magnetic resonance, he studied for one year Quantum Biochemistry as a postdoctoral fellow with Professor Pullman at the Institut de Biologie Physico-Chimique in Paris, France. Subsequently he was awarded a Swiss National Science Fellowship to study Photosynthesis and Nucleic Acid Chemistry under the guidance of Professors Calvin and Tinoco, at Berkeley, CA. In 1968/69 he worked at Princeton University as a Research Associate before joining the Chemistry faculty as an Assistant Professor at the University of Cincinnati in 1969, where he was promoted to Professor of Chemistry in 1978. In 1975, he was appointed Adjunct Associate Professor of Biological Chemistry at UC's College of Medicine, and promoted to Adjunct Professor in 1982. He was a visiting scientist at the National Institutes of Health in 1975/76, 1983/84, and at the ISREC in Lausanne, Switzerland, in 1979. In 2007/08 he was a visiting scholar at OSU.

研究领域

A) Application of electron paramagnetic resonance (EPR) spectroscopy: 1) to study dynamic features of nucleic acids and nucleic acid – protein complexes, and 2) to detect free radical damage in biological systems. B) Synthesis of spin-labeled nucleic acids as hybridization probes for genome detection by EPR. C) Development of kits for detecting the presence or absence of genes with a table top EPR instrument.

近期论文

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A Comparative Study of Scatchard-Type and Linear Lattice Models for the Analysis of EPR Competition Experiments with Spin-Labeled Nucleic Acids and Single-strand Binding Proteins, R. S. Keyes and A. M. Bobst, Biophysical Chemistry 45, 281 (1993). Detection of Internal and Overall Dynamics of a Two-Atom-Tethered Spin-Labeled DNA, R.S. Keyes and A.M. Bobst, Biochemistry 34, 9265-9276 (1995). Rigidity of a B-Z Region Incorporated into a Plasmid as Monitored by Electron Paramagnetic Resonance, O.K. Strobel, R.S. Keyes, R.R. Sinden and A.M. Bobst, Arch. Biochem. Biophys. 324, 357-366 (1995). Menadione-Induced Oxidative Stress in Bovine Heart Microvascular Endothelial Cells, W. Kossenjans, Z. Rymaszewski, J. Barankiewicz, A. Bobst and M. Ashraf, Microcirculation 3, 39-47 (1996). Spectroscopic Probe for the Detection of Local DNA Bending at an AAA Triplet, E.V. Bobst, R.S. Keyes, Y.Y. Cao and A.M. Bobst, Biochemistry 35,9309-9313 (1996). Spin-Labeled Nucleotide Mobility in the Boundary of the EcoRI Binding Site, R.S. Keyes, Y.Y. Cao, E.V. Bobst and A.M. Bobst, J. Biomol. Structure & Dynamics 14, 163-172 (1996). Overall and Internal Dynamics of DNA as Monitored by Five-Atom-Tethered Spin Labels, R.S. Keyes, E.V. Bobst, Y.Y. Cao and A.M. Bobst, Biophys. J. 72, 282-290 (1997). Spin-Labeled Nucleic Acids, R.S. Keyes and A.M. Bobst, Chapter in Biological Magnetic Resonance, Vol. 14, Spin Labeling: The Next Millennium, Plenum Publishing Corp., New York, (1998). Improved Functional Recovery of Oxygen Scavengers Histidine and Carnosine, J.W. Lee, H. Miyawaki, E.V. Bobst, J.D. Hester, M. Ashraf and A.M. Bobst, J. Mol. Cell. Cardiol. 31, 113-121 (1999). Fluorescent In Situ Detection of Encephalitozoon hellem Spores with a 6-Carboxyfluorescein-Labeled Ribosomal RNA-Targeted Oligonucleotide Probe, J.D. Hester, H.D.A. Lindquist, A.M. Bobst and F.W. Schaeffer, III, J. Euk. Microbiol. 47, 299-308 (2000). An XRD, XPS and EPR Study of Li/MgO Catalysts: Case of the Oxidative Methylation of Acetonitrile to Acrylonitrile with CH4, C.L. Bothe-Almquist, R.P. Ettireddy, A.M. Bobst and P.G. Smirniotis, J.Catalysis 192, 174-184 (2000). An Electron Spin Resonance Study of DNA Dynamics Using the Slowly Relaxing Local Structure Model, Z. Liang, J.H. Freed, R.S. Keyes and A.M. Bobst, J. Phys. Chem. B 104, 5372-5381 (2000). Increased Endogenous Ascorbyl Free Radical Formation with Singlet Oxygen Scavengers in Reperfusion Injury: An EPR and Functional Recovery Study in Rat Hearts, J.W. Lee, E.V. Bobst, Y.-G. Wang, M. Ashraf and A.M. Bobst, Cell. Mol. Biol. 46, 1383-1395 (2000). Identification of a Single Genome by Electron Paramagnetic Resonance (EPR) with Nitroxide-Labeled Oligonucleotide Probes, J.D. Hester, E.V. Bobst, D.D. Kryak and A.M. Bobst, Free Radical Research, in press.