周晓煜 - 清华大学 - 精密仪器系

个人简介

周晓煜教授课题组隶属于清华大学质谱研究团队。周晓煜教授长期从事质谱分析器原理和仿真方法开发、质谱仪器设计和优化、质谱小型化及其应用等方面的工作，在《分析化学》、《美国质谱学报》等学术期刊发表SCI 论文30余篇，担任《国际质谱学报》审稿人，获得基金委青年基金资助。教育背景 2009.4 – 2012.5 访问博士，中科院化学所 2006.9 - 2012.6 博士，武汉大学物理系 2002.9 – 2006.6 本科，武汉大学物理系工作履历 2017.2至今助理教授，清华大学精仪系 2015.5-2017.2 访问学者，清华大学精仪系 2012.6-2015.10 博士后，美国普渡大学生物医学工程系

研究领域

从事质谱分析器原理和仿真方法开发、质谱仪器设计和优化、质谱小型化及其应用等方面的工作

近期论文

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2020 X. Zhou, X. Liu, Z. Ouyang*. Statistical Algorithm Enables Rapid Computation of Space Charge Effect and Spectral Correction in a Miniature Ion Trap Mass Spectrometer. J. Am. Soc. Mass Spectrom. 2020, 31, 2, 429-433. J. Fan, P. Lian, M. Li, X. Liu, X. Zhou*, Z. Ouyang*. Ion Mobility Separation Using a Dual-LIT Miniature Mass Spectrometer. Anal. Chem. 2020, 92, 3, 2573-2579. 2019 M. Li, X. Liu, X. Zhou, Z Ouyang. Ion-Neutral Collision Effects on Ion Trapping and Pseudopotential Depth in Ion Trap Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2019, 30, 12, 2750-2755. 2018 X. Liu, X. Wang, J. Bu, X. Zhou*, Z. Ouyang*. Tandem analysis by a dual-trap miniature mass spectrometer. Anal. Chem. 2019, 91, 2, 1391-1398. W. Cao, X. Ma*, Z. Li, X. Zhou, Z. Ouyang*. Locating carbon–carbon double bonds in unsaturated phospholipids by epoxidation reaction and tandem mass spectrometry. Anal. Chem. 2018, 90, 17, 10286-10292. X. Zhou*, X. Liu, S. Chiang, W. Cao, M. Li, Z. Ouyang*. Stimulated motion suppression (STMS): A new approach to break the resolution barrier for ion trap mass spectrometry. J. Am. Soc. Mass Spectrom. 2018, DOI: 10.1007/s13361-018-1995-x. X. Zhou, X. Liu, W. Cao, X. Wang, M. Li, H. Qiao, Z. Ouyang*. Study of in-trap ion clouds by ion trajectory simulations. J. Am. Soc. Mass. Spectrom. 2018, 29, 223-229. 2016 C. Xiong, X. Zhou, Q. He, X. Huang, J. Wang, W.P. Peng, H.C. Chang, Z. Nie. Development of visible-wavelength MALDI cell mass spectrometry for high-efficiency single-cell analysis. Anal. Chem. 2016, 88, 11913?11918. C. Xiong, X. Zhou, N. Zhang, L. Zhan, Y. Chen, Z. Nie. Nonlinear ion harmonics in the Paul trap with added octopole field: theoretical characterization and new insight into nonlinear resonance effect. J. Am. Soc. Mass Spectrom., 2016, 27, 344-351. X. Wang, X. Zhou, Z. Ouyang. Direct Analysis of Nonvolatile Chemical Compounds on Surfaces Using a Hand-Held Mass Spectrometer with Synchronized Discharge Ionization Function. Anal. Chem., 2016, 88, 826–831. X. Zhou, Z. Ouyang. Ion transfer between ion source and mass spectrometer inlet: Electro-hydrodynamic simulation and experimental validation. Rapid Commun. Mass Spectrom. 2016, 30, 29-33. X. Zhou, Z. Ouyang. Following the ions through a mass spectrometer with atmospheric pressure interface – Simulation of complete ion trajectories from ion source to mass analyzer. Anal. Chem. 2016, 88, 7033-7040. 2015 C. Xiong, X. Zhou, N. Zhang, L. Zhan, Y. Chen, S. Chen, Z. Nie. A theoretical method for characterizing nonlinear effects in Paul traps with added octopole field. J. Am. Soc. Mass Spectrom., 2015, 26, 1338-1348. 2014 C.H. Chen, T.C. Chen, X. Zhou, R. Kline-Schoder, P. Sorensen, R.G. Cooks, Z. Ouyang. Design of portable mass spectrometers with handheld probes: aspects of the sampling and miniature pumping systems. J. Am. Soc. Mass Spectrom. 2014, 26, 240-247. W. Xu, L. Li, X. Zhou, Z. Ouyang. Ion sponge: a 3-dimentional array of quadrupole ion traps for trapping and mass-selectively processing ions in gas phase. Anal. Chem. 2014, 86, 4102-4109. L. Li, X. Zhou, J.W. Hager, Z. Ouyang. High efficiency tandem mass spectrometry analysis using dual linear ion traps. Analyst 2014, 139, 4779-4784. C. Xiong, X. Zhou, N. Zhang, L. Zhan, S. Chen, Z. Nie. Nonlinear effects in Paul traps operated in the second stability region: analytical analysis and numerical verification. J. Am. Soc. Mass Spectrom. 2014, 25, 1882-1889. C. Xiong, X. Zhou, N. Zhang, L. Zhan, S. Chen, J. Wang, W.P. Peng, H.C. Chang, Z. Nie. Quantitative assessment of protein adsorption on microparticles with particle mass spectrometry. Anal. Chem. 2014, 86, 3876-3881. X. Zhou, J. Liu, R.G. Cooks, Z. Ouyang. Development of miniature mass spectrometry systems for bioanalysis outside the conventional laboratories. Bioanalysis 2014, 6, 1497-1508. X. Zhou, Z. Ouyang. Flowing gas in mass spectrometer: method for characterization and impact on ion processing. Analyst 2014, 139, 5215-5222. 2013 C. Xiong, X. Zhou, J. Wang, N. Zhang, S. Chen, W.-P. Peng, H.-C. Chang, Z. Nie. Ambient aerodynamic desorption/ionization method for microparticle mass measurement. Anal. Chem. 2013, 85, 4370-4375. S. Garimella, X. Zhou, Z. Ouyang. Simulation of rarefied gas flows in atmospheric pressure interfaces for mass spectrometry systems. J. Am. Soc. Mass Spectrom. 2013, 24, 1890-1899. X. Zhou, C. Xiong, S. Zhang, N. Zhang, Z. Nie. Study of nonlinear resonance effect in Paul trap. J. Am. Soc. Mass Spectrom. 2013, 24, 794-800. 2012 R. Chen, W. Xu, C. Xiong, X. Zhou, S. Xiong, Z. Nie, L. Mao, Y. Chen, H.-C. Chang. High-salt-tolerance matrix for facile detection of glucose in rat brain microdialysates by MALDI mass spectrometry. Anal. Chem. 2012, 84, 465-469. C. Xiong, X. Zhou, J. Wang, R. Chen, Y. Tang, W.-P. Peng, H.-C. Chang, Z. Nie. The development of charge detection quadrupole ion trap mass spectrometry (CD-ITMS) driven by rectangular and triangular waves. Analyst 2012, 137, 1199-1204. X. Zhou, G. Xu, C. Xiong, R. Chen, H. Qiao, Z. Nie. Characteristics of electrical field in surface-electrode ion traps. J. Mass Spectrom.2012, 47, 286-293. 2011 X. Zhou, Z. Zhu, C. Xiong, R. Chen, W. Xu, H. Qiao, W.-P. Peng, Z. Nie, Y. Chen. Characteristics of stability boundary and frequency in nonlinear ion trap mass spectrometer. J. Am. Soc. Mass Spectrom. 2010, 21, 1588-1595. R. Chen, L. Wang, C. Xiong, Y. Zhou, C. Zhen, N. Zhang, Y. Tang, X. Zhou, J. Wang, Z. Nie, Y. Chen. Direct analysis of oligosaccharides and alpha hydroxy acids in fruits using electrosonic spray ionization mass spectrometry. Analyst 2011, 136, 3809-3814. Z. Zhu, C. Xiong, G. Xu, H. Liu, X. Zhou, R. Chen, W.-P. Peng, Z. Nie. Characteristics of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum. Analyst 2011, 136, 1305-1309. C. Xiong, X. Zhou, R. Chen, Y. Zhang, W.-P. Peng, Z. Nie, H.-C. Chang, H. Liu, Y. Chen. Characterization of column packing materials in high-performance liquid chromatography by charge-detection quadrupole ion trap mass spectrometry. Anal. Chem. 2011, 83, 5400-5406. X. Zhou, C. Xiong, G. Xu, L. Hao, Y. Tang, Z. Zhu, R. Chen, H. Qiao, Y. Tzeng, W.-P. Peng, Z. Nie, Y. Chen. Potential distribution and transmission characteristics in a curved quadrupole ion guide. J. Am. Soc. Mass Spectrom. 2011, 22, 386-398.