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个人简介

教育背景 2003-2007 吉林大学光通信系,工学学士 2007-2012 清华大学精密仪器与机械学系,工学博士 工作履历 2012-2013 哈佛大学化学与化学生物系,博士后 2013-2015 霍华德·休斯医学研究所Janelia研究校园,博士后 2015-2016 普渡大学电子与计算机工程学院,博士后 2017-至今 清华大学精密仪器系,副教授

研究领域

光学工程、生物光子学、计算成像、超快光学、生物医学科学仪器

近期论文

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2023 Sijie Fan, Shuke Wang, Changxi Yang, Frank Wise, Lingjie Kong, Advances of Mode-Locking Fiber Lasers in Neural Imaging, Advanced Optical Materials 2023, https://doi.org/10.1002/adom.202202945 Bingqian Zhou, Kuikui Fan, Jiesi Feng, Changxi Yang, Yulong Li, Songhai Shi, and Lingjie Kong, Plug-and-play fibre-optic sensors based on engineered cells for neurochemical monitoring at high specificity in freely moving animals, Science Advances 9(22), eadg0218 (2023) https://www.science.org/doi/10.1126/sciadv.adg0218 Junhao Liang, Weisheng Zhang, Jianghui Yang, Meilong Wu, Qionghai Dai, Hongfang Yin, Ying Xiao & Lingjie Kong,?Deep learning supported discovery of biomarkers for clinical prognosis of liver cancer, Nature Machine Intelligence, https://doi.org/10.1038/s42256-023-00635-3 Jiazhen Zhai, Cheng Jin, and Lingjie Kong, Compact, hybrid light-sheet and Fourier light-field micros-copy with a single objective for high-speed volumetric imaging in vivo, The Journal of Physical Chemistry A, (2023) Bingqian Zhou, Kuikui Fan, Tianfu Li, Guoming Luan, and Lingjie Kong, A biocompatible hydrogel-coated fiber-optic probe for monitoring pH dynamics in mammalian brains in vivo, Sensors and Actuators B: Chemical (2023) 2022 Jiazhen Zhai, Ruheng Shi, Kuikui Fan and Lingjie Kong, (2022). Background inhibited and speed-loss-free volumetric imaging in vivo based on structured-illumination Fourier light field microscopy, Front. Neurosci. in press Chen K, Tian Z and Kong L (2022) Advances of optical miniscopes for in vivo imaging of neural activity in freely moving animals. Front. Neurosci. 16:994079. doi: 10.3389/fnins.2022.994079 Cheng Jin*, Chi Liu*, and Lingjie Kong, High axial-resolution optical stimulation of neurons in vivo via two-photon optogenetics with speckle-free beaded-ring pattern, Photonics Research 10(6), 1367-1373 (2022) Cheng Jin; Chi Liu; Lingjie Kong; Improving Axial Resolution of Optical Stimulation in Two-Photon Optogenetics by Beaded-Ring Pattern, 2022 Biophotonics Congress: Biomedical Optic, Fort Lauderdale, Florida, USA, 24 – 27 April 2022 (Poster presentation) Jiazhen Zhai; Ruheng Shi; Lingjie Kong, High-contrast, high-speed 3D imaging in vivo with HiLo based Fourier light field microscopy, 2022 Biophotonics Congress: Biomedical Optic,Fort Lauderdale, Florida, USA, 24 – 27 April 2022 (Oral Presentation) Jiazhen Zhai*, Ruheng SHi*, Lingjie Kong, Improving signal-to-background ratio by orders of magnitude in high-speed volumetric imaging in vivo by robust Fourier light field microscopy, Photonics Research 10(5), 1255-1263 (2022) 2021 Lingjie Kong*, Conor Evans, Lei Su, Daniel S Elson, and Xunbin Wei*, Editorial: Special issue on Translational Biophotonics, Journal of Physics D: Applied Physics (accepted), 2021 Jingjing Guo*, Bingqian Zhou, Zhou Du, Changxi Yang, Lingjie Kong* and Lijun Xu, Soft and plasmonic hydrogel optical probe for glucose monitoring, Nanophotonics 2021,https://doi.org/10.1515/nanoph-2021-0360 Ruheng Shi, Yuanlong Zhang, Tiankuang Zhou, Lingjie Kong, HiLo based line scanning temporal focusing microscopy for high-speed, deep tissue imaging, Membranes 2021, 11, 634. https://doi.org/10.3390/membranes11080634 靳程,孔令杰,双光子荧光显微系统中波前像差对三维点扩散函数的影响,物理实验 2021 (已接收) Ruheng Shi and Lingjie Kong, Evaluating structured-illumination patterns in optimizing optical-sectioning of HiLo microscopy, J. Phys. D: Appl. Phys. 54 414001 (2021) Ruheng Shi; Yuanglong Zhang; Tiankuang Zhou; Lingjie Kong, Contrast and axial confinement enhancement in deep imaging via HiLo based line-scanning temporal focusing microscopy, European Conferences on Biomedical Optics Conference, post-deadline poster # EM1A.42,2021 June 20 - 24 2021 Cheng Jin; Chi Liu; Ruheng Shi; Lingjie Kong, Non-Convex Optimization With Spherical Aberration Compensation for Efficient Excitation in Two-Photon Optogenetics, European Conferences on Biomedical Optics Conference, post-deadline poster # EM1A.41,2021 June 20 – 24 孔令杰,讲好科学故事,推进研究生专业课思政教学,大学教育,2021年7月 Ruheng Shi, Yuting Li, Lingjie Kong, Recover speed loss in wide-field, optical-sectioning imaging by interleaved reconstruction, 2021 OSA Biophotonics Congress: Paper# NF1C.5 (口头报告) Cheng Jin, Ruheng Shi, Chi Liu, Lingjie Kong, Local artifacts under blood vasculatures in two photon imaging in vivo, 2021 OSA Biophotonics Congress: Paper# JW1A .23 孔令杰,靳程,金国藩,基于光遗传学的在体高空间分辨率神经调控技术,中国激光 2021(已接收) Cheng JIN, Chi LIU, Ruheng SHI, and Lingjie KONG, Precise 3D computer-generated holography based on non-convex optimization with spherical aberration compensation (SAC-NOVO) for two-photon optogenetics, Optics Express 29(13), 20795-20807 (2021) Cheng Jin, Ruheng Shi, Chi Liu, and Lingjie Kong, Recognizing local artifacts in two-photon imaging of dendrites beneath blood vessels in vivo, Chinese Optics Letter 2021 (已接收) 翟家振,施汝恒,孔令杰,光场显微镜及其在三维生物成像中的应用, 物理与工程,2021 (已接收) Ruheng Shi, Yuting Li, Lingjie Kong, High‐speed volumetric imaging in vivo based on structured illumination microscopy with interleaved reconstruction, Journal of Biophotonics (2021), https://doi.org/10.1002/jbio.202000513 (内封面文章) 2020 Yuanlong Zhang, Tiankuang Zhou, Lu Fang, Lingjie Kong, Hao Xie, and Qionghai Dai, "Conformal convolutional neural network (CCNN) for single-shot sensorless wavefront sensing," Opt. Express 28, 19218-19228 (2020) C Zhuang, X Li, Y Zhang, L Kong, H Xie, Q Dai, Photobleaching imprinting Enhanced background rejection in line-scanning temporal focusing, Frontiers in Chemistry 8, 1185 (2020) Zhong Zheng, Ruheng Shi, and Lingjie Kong "High-speed wide-field optical-sectioning fluorescence microscopy based on one-shot structured illumination", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 115532O (10 October 2020); https://doi.org/10.1117/12.2575172 翟家振,张元龙,孔令杰,简易荧光显微镜的制作及其在生物医学中的应用,物理实验 40(8), 24-27 (2020) Ruheng Shi, et al, A scheme of enhanced epi-collection of scattered photons by extended detection with silicon photomultiplier array in nonlinear fluorescence microscopy,Frontiers of Information Technology & Electronic Engineering (2020), https://doi.org/10.1631/FITEE.2000410 (邀请论文) Bingqian Zhou, Jingjing Guo, Changxi Yang, and Lingjie Kong, Upconversion-luminescent hydrogel optical probe for in situ dopamine monitoring, Photonics Research 8(11), 1800-1807 (2020) 2020 孔令杰,光学工程与脑科学的交叉融合教学 ———以“神经光子学”课程为例,物理与工程, 2020, 30(4):12-16. Cheng Jin, Lingjie Kong*, Hod Dana*, Hao Xie, Liangcai Cao, Guofan Jin and Qionghai Dai, Advances in point spread function engineering for functional imaging of neural circuits in vivo, J. Phys. D: Appl. Phys. (2020). https://doi.org/10.1088/1361-6463/ab946e Chi Liu, Zhifeng Zhao, Cheng Jin, Ying Xiao, Guoqiang Gao, Hao Xie, Qionghai Dai, Hongfang Yin*, and Lingjie Kong*, High-speed, multi-modal, label-free imaging of pathological slices with a Bessel beam, Biomedical Optics Express 11 (5), 2694-2704 (2020) 2019 Ruheng Shi, Cheng Jin, Hao Xie, Yuanlong Zhang, Xinyang Li, Qionghai Dai, and Lingjie Kong, Multi-plane, wide-field fluorescent microscopy for biodynamic imaging in vivo, Biomedical Optics Express 10(12), 6625-6635 (2019) Xinyang Li, Yuanlong Zhang, Kan Liu, Hao Xie, Haoqian Wang, Lingjie Kong, and Qionghai Dai, Adaptive optimization for axial multi-foci generation in multiphoton microscopy, Optics Express 27(24), 35948-35961 (2019) Jingjing Guo, Bingqian Zhou, Changxi Yang, Qionghai Dai, and Lingjie Kong, Stretchable and upconversion-luminescent polymeric optical sensor for wearable multifunctional sensing, Optics Letters 44(23), 5747-5750 (2019) Jingjing Guo*, Changxi Yang, Qionghai Dai,and Lingjie Kong*,Soft and Stretchable Polymeric Optical Waveguide-Based Sensors for Wearable and Biomedical Applications,Sensors 2019, 19(17), 3771; https://doi.org/10.3390/s19173771 Jingjing Guo,Bingqian Zhou,Rui Zong,Longsheng Pan,Xuemei Li,Xinguang Yu,Changxi Yang,Lingjie Kong*,Qionghai Dai,A Stretchable and Highly Sensitive Optical Strain Sensor for Human-Activity Monitoring and Healthcare, ACS Appl. Mater. Interfaces (2019), https://doi.org/10.1021/acsami.9b09815 Jingtao Fan*, Jinli Suo*, Jiamin Wu*, Hao Xie*, Yibing Shen, Feng Chen, Guijin Wang, Liangcai Cao, Guofan Jin, Quansheng He, Tianfu Li, Guoming Luan, Lingjie Kong#, Zhenrong Zheng# & Qionghai Dai#, Video-rate imaging of biological dynamics at centimetre scale and micrometre resolution, Nature Photonics (2019), https://doi.org/10.1038/s41566-019-0474-7 (*共同第一作者,#共同通讯作者) Yuanlong Zhang#, Tiankuang Zhou#, Xuemei Hu, Xinyang Li, Hao Xie, Lu Fang, Lingjie Kong,* and Qionghai Dai, Overcoming tissue scattering in wide-field two-photon imaging by extended detection and computational reconstruction, Optics Express, 27(15), 20117-20132 (2019) Jingjing Guo, Bingqian Zhou, Changxi Yang, Qionghai Dai, and Lingjie Kong, Stretchable and Temperature‐Sensitive Polymer Optical Fibers for Wearable Health Monitoring, Advanced Functional Materials, https://doi.org/10.1002/adfm.201902898 Jingjing Guo, Kangjun Zhao, Bingqian Zhou, Wen Ning, Kaili Jiang, Changxi Yang, Lingjie Kong, and Qionghai Dai, Wearable and Skin‐Mountable Fiber‐Optic Strain Sensors Interrogated by a Free‐Running, Dual‐Comb Fiber Laser, Advanced Optical Materials, https://doi.org/10.1002/adom.201900086 Yuanlong Zhang, Xinyang Li, Hao Xie, Lingjie Kong*, and Qionghai Dai, Hybrid spatio-spectral coherent adaptive compensation for line-scanning temporal focusing microscopy, J. Phys. D: Appl. Phys. 52, 024001 (2019) (入选Emerging Leaders 2019专辑) 2018 Jingjing Guo, Hanxi Huang, Minjuan Zhou, Changxi Yang, and Lingjie Kong*, Quantum Dots-Doped Tapered Hydrogel Waveguide for Ratiometric Sensing of Metal Ions, Anal. Chem. 90 (20), 12292-12298 (2018) Jingjing Guo, Yuqing Luo, Changxi Yang, and Lingjie Kong*, In situ surface-enhanced Raman scattering sensing with soft and flexible polymer optical fiber probes, Optics Letters 43 (21), 5443-5446 (2018) Yuanlong Zhang, Lingjie Kong, Hao Xie, Xiaofei Han, and Qionghai Dai, Enhancing axial resolution and background rejection in line-scanning temporal focusing microscopy by focal modulation,Optics Express, Vol. 26, Issue 17, pp. 21518-21526 (2018) Jingjing Guo, Yihang Ding, Xiaosheng Xiao, Lingjie Kong*, and Changxi Yang*, Multiplexed static FBG strain sensors by dual-comb spectroscopy with a free running fiber laser, Opt. Express 26(13), 16147-16154 (2018) (* co-corresponding author) Lingjie Kong, Yifeng Zhou, and Meng Cui, Large-field-of-view imaging by multi-pupil adaptive optics, SPIE Photonics West 2018, Paper 10502-9 (Invited Paper)

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