王戈林 - 清华大学

个人简介

1992年于武汉大学生物学系获微生物学学士学位。1998年于武汉大学生命科学学院获得遗传学博士学位后留校任教。1999年赴美国德克萨斯大学西南医学中心从事博士后研究，于2006年晋升为讲师和美国国家卫生中心大项目共同负责人。2015年加入谷歌(Google)成立的生命科学公司Calico，致力研究和开发一类抗退行性神经疾病的药物。加入清华大学药学院后的主要研究方向是了解衰老的生物学过程及抗老年病药物的筛选和研发。截至目前，已在国际权威期刊（如Cell, Nature, Nature Chemical Biology, Genes & Dev., PNAS等上发表SCI论文10余篇。专利和获奖 2022 一种超碳金簇离子型化合物及其制备方法和应用。专利号：CN 113861226B 2020 新型NAMPT酶激动剂及其制备与用途。专利号：202011525254.7，PCT/CN2022/076187 2018 Chemical activators of Nicotinamide Mononucleotide Adenlyly Transferase 2 (NMNAT2) and uses thereof. Patent No.: PCT/CN2018/117723 2017 Neuroprotective compounds and methods for identifying and using same. Patent No.: US 9645139 B2 2009 Ornithine aminotransferase (OAT): a target for anticancer drugs. Patent No.: 7622289 B2 Career Development Award (Special Fellow), Leukemia & Lymphoma Society (2003-2006)

研究领域

中国及许多发达国家正在步入老年社会，而衰老是大多慢性疾病的主要风险因子。衰老过程相当复杂，可称是生命科学的一大未解之谜。目前对其分子机制研究以及与老年相关的疾病研究和新药开发的需求日渐紧迫。本课题组主要研究兴趣是通过解析小分子药物的靶向作用来揭示衰老生物过程和调节机制，同时发现新的抗肿瘤及抗老年神经退化性疾病药物，并设计和开发相应的治疗策略。本课题组重点研究方向包括：1）从系统调节NAD生物合成的角度研究衰老生物学；2) 筛选和开发新的抗退行性神经疾病的药物和抗癌的小分子，并利用这些小分子作为探针来揭示疾病的发病机理； 3）探索新的可普遍应用的方法学来鉴定细胞内药物作用靶。我们具有良好的化学生物学，生物化学，分子生物学和细胞生物学的研究基础，也得到来自结构生物学，神经学，药物化学等多学科同行们的大力协作。

近期论文

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Yao, H.#, Liu, M.#, Wang, L.#, Zu, Y.#, Wu, C.#, Li, C., Zhang, R., Lu, H., Li, F., Chen, S., Gu, X., Liu, T., Yang, M., Hua, L., Tang Y.* and Wang, G.* (2022). Discovery of small-molecule activators of nicotinamidephosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Research 32, 570-584. Xiao, K.#; Zhang, N.#; Li, F.#; Hou, D.#; Zhai, X.; Xu, W.*; Wang, G.*; Wang, H.*; Zhao, L.* (2022). Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs. Nature Communications 13, 4669. Wang, L. B.#; Liu, M. H.#; Zu, Y. M.#; Yao, H.; Wu, C.; Zhang, R. X.; Ma, W. N.; Lu, H. G.; Hua, L.; Wang, G.*; Tang, Y. F.* (2022). Optimization of NAMPT Activators to Achieve in vivo Neuroprotective Efficacy. European Journal of Medicinal Chemistry 236, 114260. Gu, X.; Yao, H.; Kwon, I.*; Wang, G.* (2022). Small-molecule activation of NAMPT as a potential neuroprotective strategy, Life Medicine, https://doi.org/10.1093/lifemedi/lnac012. Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022). The landscape of aging. Sci China Life Sci 65, https://doi.org/10.1007/s11427-022-2161-3 Lei, X. Q.; Li, Y. H.; Lai, Y.; Hu, S. K.; Qi, C.; Wang, G.*; Tang, Y. F.* (2021). Strain-Driven Dyotropic Rearrangement: A Unified Ring-Expansion Approach to α-Methylene-γ-butyrolactones. Angew. Chem. Int. Ed. 60, 4221–4230. Wang, X., Zhou, J., Qi, C., Wang, G. (2019). Establishing cell lines overexpressing DR3 to assess the apoptotic response to anti-mitotic therapeutics. J. Vis. Exp. 143, e58705, doi:10.3791/58705. Qi, C., Wang, X., Shen, Z., Chen, S., Yu, H., Williams, N. and Wang, G. (2018). Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells. Cell Research 28, 544-555. Wang, G.#, Han, T.#, Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A.A., Ready, J.M. and McKnight, S.L. (2014). P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158, 1324-1334. Wang, G.*, Wang, X., Yu, H., Wei, S., Williams, N.S., Holmes, D.L., Halfmann, R., Naidoo, J., Wang, L., Li, L., Chen, S., Harran, P., Lei, X. and Wang. X. (2013). Small-molecule activation of the TRAIL Receptor DR5 in human cancer cells. (*First and co-corresponding author) Nature Chemical Biology 9, 84-89. Commented by Stu Borman (2013). Small molecule makes cancer want to kill itself: agent is the first small molecule found to trigger death receptor on cancer-cell surfaces. Chemical & Engineering News, 91 (2): 37. Wang, G., Shang, L., Burgett, A.W., Harran, P.G., Wang, X. (2007). Diazonamide toxin reveals a novel function for Ornithine Amino Transferase in mitotic cell division. PROC NAT ACAD SCI (USA) 104, 2068-2073. Jia, J.#, Amanai, K.#, Wang, G.#, Tang, J., Wang, B., Jiang, J. (2002). Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416, 548-552. Wang, G. and Jiang, J. (2004). Multiple Cos2/Ci complexes regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Developmental Biology 268, 493-505. Wang, G., Amanai, K., Wang, B., Jiang, J. (2000). Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus. Genes & Development 14, 2893-2905. Wang, G., Wang, B., Jiang, J. (1999). Protein Kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes & Development 13, 2828-2837. Wang, G.*, Peng, Z., Shen, P. (2000). Cloning and overexpression of the tyrosinase mel gene from Pseudomonas maltophilia. (*First and corresponding author) FEMS Microbiology Letters 185, 23-27. Jesús-Cortés, H.D., Xu, P., Drawbridge, J., Estill, S.J., Huntington, P., Tran, S., Britt, J., Tesla, R., Morlock, L., Naidoo, J., Melito, L.M., Wang, G., Williams, N.S., Ready, J.M., McKnight, S.L., and Pieper, A.A. (2012). Neuroprotective e?cacy of aminopropyl carbazoles in a mouse model of Parkinson disease. PNAS 109, 17010-17015. Gao, S., Wang, Q., Wang, G., Lomenick, B., Liu, J., Fan, C.W., Deng, L.W., Huang, J., Lum, L., Chen, C. (2012). The chemistry and biology of Nakiterpiosin – C-nor-D-Homos- teroids. Synlett 16, 2298-2310. Zhang, W., Zhao, Y., Tong, C., Wang, G., Wang, B., Jia, J. and Jiang, J. (2005). Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Developmental Cell 8, 267-278. Liu, Y., Wang, G., Zhao, R., Shen, P. and Qu, S. (2005). Microcalorimetric study on the growth of Escherichia coli HB101 e?ected by recombinant plasmid. ACTACHIMI- CASINICA 63, 327-331.