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个人简介

谭旭博士于2003年在中国科技大学获得生物学学士学位,并于2007年在美国西雅图的华盛顿大学获得药理学博士学位;2008年至2014年在哈佛大学医学院进行博士后研究;2014年开始在清华大学建立实验室,致力于病毒-宿主相互作用的研究和抗病毒药物开发

研究领域

谭旭实验室运用先进的高通量筛选方法进行抗病毒药物开发研究。生物信息学,活细胞成像,生物化学和结构生物学的手段是我们研究新型药物的作用机制的方法。同时我们运用功能基因组学大规模遗传筛选的方法以及全蛋白组质谱的手段来系统的研究人类抗病毒天然免疫的机制。我们对基于RNA的药物开发也非常有兴趣。我们的研究对象主要是艾滋病毒,乙肝病毒,流感病毒和登革热病毒。另外,我们对关于泛素-蛋白酶体有关的疾病机制和药物开发也有研究。实验室的学生将学习掌握高通量生物学的手段在新药开发中的应用,同时也将得到病毒学,细胞生物学和遗传学的训练

近期论文

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Liu Y*, Fu Y*, Wang Q, Li M, Zhou Z, Dabbagh D, Fu C, Zhang H, Li S, Zhang T, Gong J, Kong X, Zhai W, Su J, Sun J, Zhang Y, Yu XF, Shao Z, Zhou F#, Wu Y#, Tan X#. Proteomic profiling of HIV-1 infection of human CD4+ T cells identifies PSGL-1 as an HIV restriction factor. Nature Microbiology (2019) 4(5):813 Li P*, Wei Y*, Mei M*, Tang L*, Sun L, Huang W, Zhou J, Zou C, Zhang S, Qin CF, Jiang T, Dai J, Tan X#, Zhang QC#. Integrative Analysis of Zika Virus Genome RNA Structure Reveals Critical Determinants of Viral Infectivity. Cell Host & Microbe (2018) 24(6):875 Jiang C*, Mei M*, Li B*, Zhu X*, Zu W, Tian Y, Wang Q, Guo Y, Dong Y#, Tan X#. A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and PCSK9 in vivo. Cell Research (2017) 27(3):440 Lin Z*, Li S*, Feng C*, Yang S, Wang H, Ma D, Zhang J, Gou M, Bu D, Zhang T, Kong X, Wang X, Sarig O, Ren Y, Dai L, Liu H, Zhang J, Li F, Hu Y, Padalon-Brauch G, Vodo D, Zhou F, Chen T, Deng H, Sprecher E, Yang Y#, Tan X#. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Nature Genetics (2016) 48(12): 1508 Tan X, Elledge SJ. When noise makes music: HIV reactivation with transcriptional noise enhancers. Genome Medicine (2014) 6(7): 55 Tan X, Hu L, Luquette LJ III, Gao G, Liu Y, Qu H, Xi R, Park PJ, Elledge SJ. Systematic Identification of Synergistic Drug Pairs Targeting HIV. (2012) Nature Biotechnology 30(11):1125 Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ. Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. (2012) Proc Natl Acad Sci U S A. 109 (3): 869 Calderón Villalobos LI, Lee S, De Oliveira C, Ivetac A, Brandt W, Armitage L, Sheard LB, Tan X, Parry G, Mao H, Zheng N, Napier R, Kepinski S, Estelle M. A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin. (2012) Nature Chemical Biology 8(5): 477 Sheard LB*, Tan X*, Mao H*, Withers J, Ben-Nissan G, Hinds TR, Kobayashi Y, Hsu FF, Sharon M, Browse J, He SY, Rizo J, Howe GA, Zheng N, Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. (2010) Nature 468(7322): 400 Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ, A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. (2010) Proc Natl Acad Sci USA. 107(43): 18475 Calderon-Villalobos LI, Tan X, Zheng N, Estelle M, Auxin perception--structural insights.(2010) Cold Spring Harb Perspect Biol. 2(7):a005546 (Review) Tan X, Calderon-Villalobos LIA, Sharon M, Zheng C, Robinson CV, Estelle M & Zheng N, Mechanism of Auxin Perception by the TIR1 ubiquitin ligase. (2007) Nature 446(7136): 640(Cover Article) Tan X & Zheng N, Hormone Signaling Through Protein Destruction - A Lesson From Plants. (2009) American Journal of Physiology – Endocrinology & Metabolism 296:223(Review) Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S, Nozaki H, Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception. (2008) Proc Natl Acad Sci U S A. 105(14): 5632 Wacker JL, Feller DB, Tang XB, DeFino MC, Namkung Y, Lyssand J, Mhyre AJ, Tan X, Jensen JB & Hague C, Disease causing mutation in GPR54 reveals importance of second intracellular loop for class A GPCR function. (2008) Journal of Biological Chemistry 283(45): 31068 Andersen NH, Olsen KA, Fesinmeyer RM, Tan X, Hudson FM, Eidenschink LA & Farazi SR, Minimization and Optimization of Designed Beta-Hairpin Folds (2006) Journal of American Chemical Society 128(18): 6101

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