个人简介

B.S., University of California, Los Angeles Ph.D., University of California, Santa Barbara

研究领域

Marine natural products chemistry, bioorganic chemistry, organic structural analysis by NMR, natural products of marine macro- and microorganisms

Organic Chemistry, Marine Chemistry, Natural Products A primary goal of Phillip Crews' marine natural products research is to understand the chemistry of tropical marine sponges. Using bioassay-guided isolation assists us in the discovery of natural products potent against human diseases such as cancer or viruses. Our search for novel active compounds incorporates elements of structure elucidation but there are other dimensions to this research, including questions in the areas of chemical ecology, marine natural products biosynthesis, and the relationship between secondary metabolite chemistry and taxonomy. Added to these interests are emerging projects which examine sponges as a source of new cultured marine microorganisms. We are also interested in examining sponges that are rich with cyanobacterial symbionts. Whenever possible, we try to use new concise strategies to elucidate structures, including gradient 2D NMR techniques such as gs-HMBC, gs-HMQC, gs-COSY, gs-TOCSY, gs-NOESY, and 1H-15N gs HMQC. Utilization of new NMR hardware, 3mm probes and advanced NMR microtubes, addresses problems of limited amounts of sample. Another goal is to engage in follow-up studies that employ molecular mechanics data combined with these state-of-the-art NMR techniques. An additional subject of interest is to explore marine fungi as a source of secondary metabolites. The goal is to isolate novel bioactive substances from fungi cultured from marine sponges in order to discover new structural classes of natural products. We are developing strategies that will maximize the diversity and secondary metabolite production of cultured marine fungi.

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Johnson, T. A.; Sohn, J.; Vaske, Y. M.; White, K. N.; Cohen, T. L.; Vervoort, H. C.; Tenney, K.; Valeriote, F. A.; Bjeldanes, L. F.; Crews, P. Myxobacteria versus sponge-derived alkaloids: The bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg. & Med. Chem. 2012, 20, 4348-4355. Jiang, H. L.; Luo, X. H.; Wang, X. Z.; Yang, J. L.; Yao, X. J.; Crews, P.; Valeriote, F. A.; Wu, Q. X. New isocoumarins and alkaloid from Chinese insect medicine, Eupolyphaga sinensis Walker. Fitoterapia 2012, 83, 1275-1280. Luo, X. H.; Wang, X. Z.; Jiang, H. L.; Yang, J. L.; Crews, P.; Valeriote, F. A.; Wu, Q. X. The biosynthetic products of Chinese insect medicine, Aspongopus chinensis. Fitoterapia 2012, 83, 754-758. Wu, Q. X.; Jin, X. J.; Draskovic, M.; Crews, M. S.; Tenney, K.; Valeriote, F. A.; Yao, X. J.; Crews, P. Unraveling the numerous biosynthetic products of the marine sediment-derived fungus, Aspergillus insulicola. Phytochem Let. 2012, 5, 114-117. Watts K.R., Morinaka B.I., Amagata T., Robinson S.J., Tenney K., Bray W.M., Gassner N.C., Lokey R.S., Media J., Valeriote F.A., and Crews P. Biostructural Features of Additional Jasplakinolide (Jaspamide) Analogues. J. Nat. Prod., 2011, 74, 341-351. Inman W.D. and Crews P. Unraveling the Bastarane and Isobastarane Oximo Amide Configurations and Associated Macrocycle Conformations: Implications of Their Influence on Bioactivities. J. Nat. Prod., 2011, 74, 402-410. Vervoort H.C., Drašković M., and Crews P. Histone Deacetylase Inhibitors as a Tool to Up-Regulate New Fungal Biosynthetic Products: Isolation of EGM-556, a Cyclodepsipeptide, from Microascus sp. Org. Lett., 2011, 13, 410-413. Watts, K.R.; Tenney, K.; Crews, P. The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules. Current Opinion in Biotechnology 2010, 21, 808-818. Calcul, L.; Tenney, K.; Ratnam, J.; McKerrow, J.H.; Crews, P. Structural Variations to the 9-N-Methyladeninium Diterpenoid Hybrid Commonly Isolated from Agelas Sponges. Australian Journal of Chemistry 2010, 63, 915-921. Robinson, S.J.; Morinaka, B.I.; Amagata, T.; Tenney, K.; Bray, W.M.; Gassner, N.C.; Lokey, R.S.; Crews, P. New Structures and Bioactivity Properties of Jasplakinolide (Jaspamide) Analogues from Marine Sponges. J. Med. Chem. 2010, 534, 1651-1661. Wu, Q.X.; Crews, M.S.; Draskovic, M.; Sohn, J.; Johnson, T.A.; Tenney, K.; Valeriote, F.A.; Yao, X.J.; Bjeldanes, L.F.; Crews, P. Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola. Org. Lett. 2010, 12, 4458-4461. Watts, K.R.; Ratnam, J.; Ang, K.H.; Tenney, K.; Compton, J.E.; McKerrow, J.; Crews, P. Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. Bioorganic & Medicinal Chemistry 2010, 18, 2566-2574. Johnson, T.A.; Morgan, M.V.C.; Aratow, N.A.; Estee, S.A.; Sashidhara, K.V.; Loveridge, S.T.; Segraves, N.L.; Crews, P. Assessing Pressurized Liquid Extraction for the High-Throughput Extraction of Marine-Sponge-Derived Natural Products. J. Nat. Prod. 2010, 73, 359-364. Calcul, L.; Inman, W.D.; Morris, A.A.; Tenney, K.; Ratnam, J.; McKerrow, J.H.; Valeriote, F.A.; Crews, P. Additional Insights on the Bastadins: Isolation of Analogues from the Sponge Ianthella cf. reticulata and Exploration of the Oxime Configurations. J. Nat. Prod. 2010, 73, 365-372. Inman, W.D.; Bray, W.M.; Gassner, N.C.; Lokey, R.S.; Tenney, K.; Shen, Y.Y.; TenDyke, K.; Suh, T.; Crews, P. A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus J. Nat. Prod. 2010, 73, 255-257.