郑撼球 - 清华大学

个人简介

郑撼球教授本科毕业于南京大学，2010年在Albany Medical College获博士学位。在普林斯顿大学分子生物学系完成博后研究后，2016年底加入清华大学医学院，任研究员、博士生导师至今。在博士后阶段获得多项基金资助，包括Susan Komen基金会博后资助。回国后入选国家人才计划，获拜耳研究员奖。

研究领域

郑撼球实验室目前在乳腺癌骨转移的早期定植信号分析、耐药发生机制等方面有大量的细胞模型、小鼠模型及技术分析方法的积累。

近期论文

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Fan H.; Wang X.; Li W.; Shen M.; Wei Y.;Zheng H.*;Kang Y.*; ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP,Genes & Development, 2020, 34(19-20): 1359-1372 LiW.; ShenM.; JiangY.Z.; ZhangR.;ZhengH.;Wei Y.;Shao Z.M.;KangY.*; Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2,Genes&Development,2020, 34(19-20): 1310-1315 Esposito M*,MondalN, Greco TM, Yong W, Spadazzi C, Lin SC,Zheng H, Cheung C, Magnani JL, Lin SH, Cristea IM,SacksteinR, Kang Y # (2019) Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasisNature Cell Biology, 21(5): 627-639 PMID: 30988423 Shen M*, Jiang YZ, Wei Y, Ell B, Sheng X, Esposito M, Kang J, Hang X,Zheng H, Rowicki M, Zhang L, Shih WJ, Celià-Terrassa T, Liu Y, Cristea I, Shao ZM, Yibin Kang # (2019) Tinagl1 suppresses triple-negative breast cancer progression and metastasis by simultaneously inhibiting integrin/FAK and EGFR signalingCancer Cell, 35(1): 64-80.e7 PMID: 30612941 Zheng H*, Bae Y*, Kasimir-bauer S, Tang R, Chen J, Ren G, Yuan M, Esposito M, Li W, Wei Y, Shen M, Zhang L, Tupitsyn N, Pantel K, King C, Sun J, Moriguchi J, Jun HT, Coxon A,Lee B # , Kang Y # (2017) Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to ChemotherapyCancer Cell, 32(6): 731-47 e6 PMID: 29232552 Zheng H, Li W, and Kang Y. (2017)Tumor –Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications.Cold Spring Harb. Symp. Quant. Biol., doi: 10.1101/sqb.2016.81.030775 Zheng H & Kang Y(2015)Cradle of evil: osteogenic niche forearlybone metastasisCancer Cell27(2): 153-5. PMID: 25670074 Zheng H, Shen M, Cha Y-L, Li W, Wei Y, Blanco MA, Ren G, Zhou T, Storz P, Wang H-Y, and Kang Y. (2014) PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.Cancer Cell, 26(3): 358-73. PMID: 25203322 Zheng, H& Kang, Y. (2014) Multilayer control of the EMT master regulators.Oncogene33, 1755-1763. PMID: 23604123 Zhao D*,Zheng HQ*, Zhou Z, and Chen C(2010)The Fbw7 tumor suppressor targets KLF5 for ubiquitinmediated degradation and suppresses breast cell proliferation.Cancer Res., 70(11):4728-38. PMID: 20484041 Liu R,Zheng HQ, Zhou Z, Dong JT, and Chen C (2009) KLF5 promotes breast cell survival partially through FGF-BP-pERK-mediated MKP-1 protein phosphorylation and stabilization.J Biol. Chem., 284(25):16791-8. PMID: 19668233 Zheng HQ, Zhou Z, Huang J, Chaudhury L, Dong JT, and Chen C (2009) Kruppel-Like Factor 5 Promotes Breast Cell Proliferation Partially through Upregulating the Transcription of Fibroblast Growth Factor-Binding