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个人简介

于1992年获得英国爱丁堡大学分子病毒学博士学位,之后在美国纽约大学和洛克菲勒大学担任助理教授和副教授。2007年全职任教于清华大学,现为清华大学医学院长聘教授,北京协和医学院兼职教授,博士生导师,清华大学艾滋病综合研究中心主任。曾获国家自然科学基金委“海外杰出青年基金”和“杰出青年科学基金”,教育部“长江学者”特聘教授。是国内外多个传染病和疫苗研究机构和组织的咨询专家。2016当选首位中国籍非洲科学院院士。

研究领域

张林琦教授长期从事针对病毒感染和保护性免疫机制的研究,在疫苗的免疫原设计与优化、载体的选择和构建、保护性抗体反应的机制以及评估等方面取得了突出的成绩,发表上百篇高水平的科研论文,多个抗体和疫苗已经在国内外进入人体临床试验。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Zhang Qi, Ju Bin, Ge Jiwan, Chan Jasper Fuk-Woo, Cheng Lin, Wang Ruoke, Huang Weijin, Fang Mengqi, Chen Peng, Zhou Bing, Song Shuo, Shan Sisi, Yan Baohua, Zhang Senyan, Ge Xiangyang, Yu Jiazhen, Zhao Juanjuan, Wang Haiyan, Liu Li, Lv Qining, Fu Lili, Shi Xuanling, Yuen Yung Kwok, Liu Lei, Wang Youchun, Chen Zhiwei, Zhang Linqi, Wang Xinquan, Zhang Zheng. (2021). Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nature Communications, 12, 1–12. https://doi.org/10.1038/s41467- 021-24514-w Li Mingxi, Guo Jingao, Lu Shuaiyao, Zhou Runhong, Shi Hongyang, Shi Xuanling, Cheng Lin, Liang Qingtai, Liu Hongqi, Wang Pui, Wang Nan, Wang Yifeng, Fu Lili, Xing Man, Wang Ruoke, Ju Bin, Liu Li, Lau Siu-Ying, Jia Wenxu, Tong Xin, Yuan Lin, Guo Yong, Qi Hai, Zhang Qi, Huang Zhen, Chen Honglin, Zhang Zheng, Chen Zhiwei, Peng Xiaozhong, Zhou Dongming, Zhang Linqi. (2021). Single-dose immunization with a chimpanzee adenovirusbased vaccine induces sustained and protective immunity against SARS-CoV-2 infection. Frontiers in Immunology, 12, 1–14. https://doi.org/10.3389/fimmu.2021.697074 Wang Ruoke, Zhang Qi, Ge Jiwan, Ren Wenlin, Zhang Rui, Lan Jun, Ju Bin, Su Bin, Yu Fengting, Chen Peng, Liao Huiyu, Feng Yingmei, Li Xuemei, Shi Xuanling, Zhang Zheng, Zhang Fujie, Ding Qiang, Zhang Tong, Wang Xinquan, Zhang Linqi. (2021). Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species. Immunity. https://doi.org/10.1016/j.immuni.2021.06.003 Yan Renhong, Wang Ruoke, Ju Bin, Yu Jinfang, Zhang Yuanyuan, Liu Nan, Wang Jia, Zhang Qi, Chen Peng, Zhou Bing, Li Yaning, Shen Yaping, Zhang Shuyuan, Tian Long, Guo Yingying, Xia Lu, Zhong Xinyue, Cheng Lin, Ge Xiangyang, Zhao Juajuan, Wang Hong-Wei, Wang Xinquan, Zhang Zheng, Zhang Linqi, Zhou Qiang. (2021). Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Research, 31(5), 517–525. https://doi.org/10.1038/s41422-021-00487-9 Ge Jiwan, Wang Ruoke, Ju Bin, Zhang Qi, Sun Jing, Chen Peng, Zhang Senyan, Tian Yuling, Shan Sisi, Cheng Lin, Zhou Bing, Song Shuo, Zhao Juanjuan, Wang Haiyan, Shi Xuanling, Ding Qiang, Liu Lei, Zhao Jincun, Zhang Zheng, Wang Xinquan, Zhang Linqi. (2021). Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nature Communications, 12(1), 1–9. https://doi.org/10.1038/s41467-020-20501-9 Ju Bin, Zhang Qi, Ge Jiwan, Wang Ruoke, Sun Jing, Ge Xiangyang, Yu Jiazhen, Shan Sisi, Zhou Bing, Song Shuo, Tang Xian, Yu Jinfang, Lan Jun, Yuan Jing, Wang Haiyan, Zhao Juanjuan, Zhang Shuye, Wang Youchun, Shi Xuanling, Liu Lei, Zhao Jincun, Wang Xinquan, Zhang Zheng, Zhang Linqi. (2020). Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 584(7819), 115–119. https://doi.org/10.1038/s41586-020-2380-z Lan Jun, Ge Jiwan, Yu Jinfang, Shan Sisi, Zhou Huan, Fan Shilong, Zhang Qi, Shi Xuanling, Wang Qisheng, Zhang Linqi, Wang Xinquan. (2020). Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature, 581(7807), 215–220. https://doi.org/10.1038/s41586-020-2180-5 Wang Qian, Zhang Linqi. (2020). Broadly neutralizing antibodies and vaccine design against HIV-1 infection. Frontiers of Medicine, 14(1), 30–42. https://doi.org/10.1007/s11684-019-0721-9 Zhou Panpan, Wang Han, Fang Mengqi, Li Yangyang, Wang Hua, Shi Shasha, Li Zihao, Wu Jiapeng, Han Xiaoxu, Shi Xuanling, Shang Hong, Zhou Tongqing, Zhang Linqi. (2019). Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies. PLoS Pathogens, 15(6), 1–24. https://doi.org/10.1371/journal.ppat.1007819 Xu Jiuyang, Jia Wenxu, Wang Pengfei, Zhang Senyan, Shi Xuanling, Wang Xinquan, Zhang Linqi. (2019). Antibodies and vaccines against Middle East respiratory syndrome coronavirus. Emerging Microbes and Infections, 8(1), 841–856. https://doi.org/10.1080/22221751.2019.1624482

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