张敬仁 - 清华大学

个人简介

1997年获美国得克萨斯大学医学中心博士学位，并于1997年进入美国圣祖德儿童医院研究所从事博士后研究工作。2000年至2010年，于美国阿尔巴尼医学院任助理教授、副教授。2010年回国至今于清华大学任医学院长聘教授。曾荣获美国微生物学会Raymond W. Sarber奖、美国德克萨斯大学Chancellor’s Entrepreneurship and Innovation Award in Category II、中国国家自然科学基金杰出青年B类基金等。

研究领域

张敬仁教授团队主要致力于急性细菌性肺炎及败血症病原菌遗传、表观遗传、与宿主相互作用的机制、疫苗保护机制的研究及新型蛋白疫苗的研发，旨为急性细菌感染性疾病的精准诊断、治疗和预防提供新的分子靶标及策略。研究结果于《Cell》、《Nucleic Acids Research》、《PLoS Pathogens》等国际著名杂志发表，并多次入选中国高被引学者。团队通过反向疫苗学策略还发现了多个具有免疫保护效果的肺炎链球菌蛋白抗原，相关成果已获得中国和美国的专利保护。

近期论文

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Huang, Xueting, Xiuyuan Li, Haoran, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu and Jing-Ren Zhang*. Capsule type defines the capacity of Klebsiella pneumoniae in evading Kupffer cell capture in the liver. PLOS Pathogens. In press. Guo, Ziyi, Haoqi Yang, Jing-Ren Zhang, Wenwen Zeng, and Xiaoyu Hu. Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation. Science Advances. In press. Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco R. Oggioni, John M. Leong, Jan-Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, and Jing-Ren Zhang*. 2022. Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria. Journal of Experimental Medicine 219:e20212032. DOI:10.1084/jem.20212032. Menglan Zhou, Ziran Wang, Li Zhang, Timothy Kudinha, Haoran An, Chenyun Qian, Jiang Bin, Yao Wang, YingChun Xu, Zhengyin Liu*, Hong Zhang* and Jing-Ren Zhang*. 2022. Serotype distribution, antimicrobial susceptibility, multilocus sequencing type and virulence of invasive Streptococcus pneumoniae in China: a six-year multi-center study. Frontiers in Microbiology 12:798750. DOI:10.3389/fmicb.2021.798750. Qingqing Hu, Huichun Tong, Jing Wang, Pupu Ge, Lin Zhu, Cuihua Liu, Jing-Ren Zhang, Xiuzhu Dong. 2021. A novel aquaporin subfamily imports oxygen and contributes to pneumococcal virulence by controlling production and release of virulence factors. mBio 12:e01309-21. https://doi.org/10.1128/mBio.01309-21. Zhang, Chengwang, Haoran An, Jiao Hu, Jing Li, Wenhao Zhang, Xun Lan, Haiteng Deng, and Jing-Ren Zhang*. 2021. MetR is a molecular adaptor for pneumococcal carriage in the healthy upper airway. Molecular Microbiology 116:438-458. DOI:10.1111/MMI.14724. Huang, Xueting, Juanjuan Wang, Jing Li, Yanni Liu, Xue Liu, Zeyao Li, Kurni Kurniyati, Yijie Deng, Guilin Wang, Joseph D. Ralph, Megan De Ste Croix, Sara Escobar-Gonzalez, Richard J. Roberts, Jan-Willem Veening, Xun Lan, Marco R. Oggioni*, Chunhao Li*, and Jing-Ren Zhang*. 2020. Prevalence of phase variable epigenetic invertons among host-associated bacteria. Nucleic Acids Research 48:11468-11485. DOI:10.1093/nar/gkaa907. Wang, Juanjuan, Jing-Wen Li, Yijia Huang, Shaolin Wang, and Jing-Ren Zhang*. 2020. Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems. PLOS Pathogens 16 (3):e1008417. DOI:10.1371/journal.ppat.1008417. Li, Jing.-Wen, Juanjuan Wang, Sofia Ruiz-Cruz, Manuel Espinosa, Jing-Ren Zhang*, and Alicia Bravo*. 2020. In vitro DNA inversions mediated by the PsrA site-specific tyrosine recombinase of Streptococcus pneumoniae. Frontiers in Molecular Biosciences 7:43. DOI:10.3389/fmolb.2020.00043. Li, Jing-Wen, Jing Li, Juanjuan Wang, Chunhao Li, and Jing-Ren Zhang*. 2019. Molecular mechanisms of hsdS inversions in the cod locus of streptococcus pneumoniae. Journal of Bacteriology 201(6):e00581-18. DOI:10.1128/JB.00581-18. Chosen by the editor as the Article of Significant Interest in This Issue, DOI:10.1128/JB.00023-19.