向烨 - 清华大学

个人简介

向烨研究员1998年本科毕业于北京大学化学系，2003年获中科院生物物理所博士学位。2005年1月赴美国普渡大学从事博士后研究，并于2010年晋升为助理研究科学家。2012年入选中组部青年计划。2019年入选国家杰青。2013年1月回清华大学任教，现为清华大学医学院研究员，博士生导师，长聘副教授。

研究领域

向烨研究员的科研重点是人类重大病毒性传染病的致病机理，病毒与免疫系统相互作用关系，抗病毒药物和疫苗研发。主要研究方向包括乙肝病毒，登革热病毒，甲病毒、新型冠状病毒肺炎病毒等高致病性病毒。

近期论文

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Watson A, Li H, Ma B, Weiss R, Bendayan D, Abramovitz L, Ben-Shalom N, Mor M, Pinko E, Bar Oz M, Wang Z, Du F, Lu Y, Rybniker J, Dahan R, Huang H, Barkan D, Xiang Y*, Javid B*, Freund NT*. Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat Commun. 2021 Jan 27;12(1):602. Gao J, Gui M*, Xiang Y*. Structural intermediates in the low pH-induced transition of influenza hemagglutinin. PLoS Pathog. 2020 Nov 30;16(11):e1009062. Wang Q, Ma B, Liang Q, Zhu A, Wang H, Fu L, Han X, Shi X, Xiang Y, Shang H, Zhang L. Stabilized diverse HIV1 envelope trimers for vaccine design. Emerg Microbes Infect. 2020 Dec;9(1):775-786. Wang C, Pei Y, Wang L, Li S, Jiang C, Tan X, Dong Y, Xiang Y*, Ma Y*, Liu G*. Discovery of (1H- Pyrazolo[3,4-c]pyridin-5-yl)sulfonamide Analogues as Hepatitis B Virus Capsid Assembly Modulators by Conformation Constraint. J Med Chem. 2020 Jun 11;63(11):6066-6089. Wang L, Xiang Y*. Spike Glycoprotein-Mediated Entry of SARS Coronaviruses. Viruses. 2020 Nov 11;12(11):E1289. Invited review. Huang L, Xiang Y*. Structures of the tailed bacteriophages that infect Gram-positive bacteria. Curr Opin Virol. 2020 Oct 31;45:65-74. Invited review. Liu Q, Ma B, Qian N, Zhang F, Tan X, Lei J, Xiang Y*. Structure of the African swine fever virus major capsid protein p72. Cell Res. 2019 Nov;29(11):953-955. He M, Luo P, Hong J, Wang X, Wu H, Zhang R, Qu F, Xiang Y*, Xu W*. Structural Analysis of Biomolecules through a Combination of Mobility Capillary Electrophoresis and Mass Spectrometry. ACS Omega. 2019 Jan 31;4(1):2377-2386. Wang L, Wang R, Wang L, Ben H, Yu L, Gao F, Shi X, Yin C, Zhang F, Xiang Y*, Zhang L*. Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep. 2019 Mar 19;26(12):3360- 3368.e5. Wang W, Chen S, An B, Huang K, Bai T, Xu M, Bellot G, Ke Y, Xiang Y*, Wei B*. Complex wireframe DNA nanostructures from simple building blocks. Nat Commun. 2019 Mar 6;10(1):1067. Xu J, Dayan N, Goldbourt A*, Xiang Y*. Cryo-electron microscopy structure of the filamentous bacteriophage IKe. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5493-5498. Pei Y, Wang C, Ben H, Wang L, Ma Y, Ma Q, Xiang Y, Zhang L, Liu G. Discovery of New Hepatitis B Virus Capsid Assembly Modulators by an Optimal High-Throughput Cell-Based Assay. ACS Infect Dis. 2019 Feb 22. Song W, Gui M, Wang X*, Xiang Y* (2018) Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PLoS Pathog 14(8): e1007236. https://doi.org/10.1371/journal.ppat.1007236 Gao JJ, Yao LC, Xia TT, Liao XB, Zhu DY*, Xiang Y*. Biochemistry and structural studies of kynurenine 3- monooxygenase reveal allosteric inhibition by Ro 61-8048. FASEB J. 2018. 32:2036-2045. *Corresponding